Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder

Voxel-Based Morphometry—The Methods

2000 • 8,281 citations

The Hippocampus as a Cognitive Map

1978 • 8,087 citations

Emotion Circuits in the Brain

2000 • 8,055 citations

Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study

1997 • 7,096 citations

Cognitive and emotional influences in anterior cingulate cortex

2000 • 6,010 citations

The hippocampus as a cognitive map

1979 • 5,527 citations

Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.

1992 • 5,156 citations

A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains

2001 • 4,495 citations

Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

1997 • 4,490 citations

Neurotrophins: Roles in Neuronal Development and Function

2001 • 4,134 citations

Prevalence, Severity, and Unmet Need for Treatment of Mental Disorders in the World Health Organization World Mental Health Surveys

2004 • 3,358 citations

Contributions of anterior cingulate cortex to behaviour

1995 • 3,315 citations

A Neurotrophic Model for Stress-Related Mood Disorders

2006 • 3,154 citations

Functional neurogenesis in the adult hippocampus

2002 • 2,813 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

Common regions of the human frontal lobe recruited by diverse cognitive demands

2000 • 2,465 citations

Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

1999 • 2,351 citations

Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala

1994 • 2,309 citations

Frontal-Subcortical Circuits and Human Behavior

1993 • 2,248 citations

Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

1997 • 2,235 citations

Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge

1998 • 2,215 citations

Neurobiology of emotion perception I: the neural basis of normal emotion perception

2003 • 2,121 citations

Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop

1995 • 2,101 citations

Abstract reward and punishment representations in the human orbitofrontal cortex

2001 • 2,023 citations

Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders

2000 • 1,927 citations

Hippocampal atrophy in recurrent major depression.

1996 • 1,884 citations

Episodic memory, amnesia, and the hippocampal–anterior thalamic axis

1999 • 1,860 citations

Neurobiology of emotion perception II: implications for major psychiatric disorders

2003 • 1,694 citations

Primate anterior cingulate cortex: Where motor control, drive and cognition interface

2001 • 1,673 citations

Conscious and unconscious emotional learning in the human amygdala

1998 • 1,673 citations

Hippocampal Volume Reduction in Major Depression

2000 • 1,645 citations

A specific neural substrate for perceiving facial expressions of disgust

1997 • 1,616 citations

Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin

1989 • 1,570 citations

Glial reduction in the subgenual prefrontal cortex in mood disorders

1998 • 1,497 citations

Hippocampal Volume and Depression: A Meta-Analysis of MRI Studies

2004 • 1,491 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Human Amygdala Activation during Conditioned Fear Acquisition and Extinction: a Mixed-Trial fMRI Study

1998 • 1,389 citations

Double Dissociation of Conditioning and Declarative Knowledge Relative to the Amygdala and Hippocampus in Humans

1995 • 1,386 citations

Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression

1999 • 1,371 citations

Cognition and motivation in emotion.

1991 • 1,362 citations

Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidium in basal ganglia circuitry

1995 • 1,339 citations

Neuroimaging studies of mood disorders

2000 • 1,303 citations

Dissociation of reward anticipation and outcome with event-related fMRI

2001 • 1,303 citations

Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli

1990 • 1,275 citations

Acute Effects of Cocaine on Human Brain Activity and Emotion

1997 • 1,263 citations

The functions of the orbitofrontal cortex

2004 • 1,254 citations

Williams Textbook of Endocrinology

1999 • 1,226 citations

Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys

1995 • 1,216 citations

Decreased serum brain-derived neurotrophic factor levels in major depressed patients

2002 • 1,199 citations

The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

2003 • 1,188 citations

Failure to Respond Autonomically to Anticipated Future Outcomes Following Damage to Prefrontal Cortex

1996 • 1,173 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Cognition and motivation in emotion.

1991 • 1,162 citations

Untreated Depression and Hippocampal Volume Loss

2003 • 1,140 citations

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

2001 • 1,136 citations

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

2003 • 1,125 citations

Depression: Perspectives from Affective Neuroscience

2002 • 1,118 citations

Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment

2003 • 1,115 citations

Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response

2000 • 1,113 citations

Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis

2004 • 1,101 citations

The neural basis of romantic love

2000 • 1,018 citations

Course of illness, hippocampal function, and hippocampal volume in major depression

2003 • 962 citations

Toward a Comprehensive Developmental Model for Major Depression in Women

2002 • 934 citations

Extinction of emotional learning: Contribution of medial prefrontal cortex

1993 • 895 citations

The Prefrontal Cortex: Response Selection or Maintenance Within Working Memory?

2000 • 865 citations

Activation of the hippocampus in normal humans: a functional anatomical study of memory.

1992 • 853 citations

Depression and memory impairment: A meta-analysis of the association, its pattern, and specificity.

1995 • 850 citations

Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)

1997 • 829 citations

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

2000 • 810 citations

Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression

2002 • 798 citations

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

1986 • 773 citations

Attenuation of the Neural Response to Sad Faces in Major Depressionby Antidepressant Treatment

2004 • 767 citations

Neuroanatomical correlates of happiness, sadness, and disgust

1997 • 758 citations

Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder

2001 • 754 citations

The neurotrophin hypothesis for synaptic plasticity

2000 • 729 citations

Increased neurogenesis in a model of electroconvulsive therapy

2000 • 726 citations

Structural Brain Magnetic Resonance Imaging of Limbic and Thalamic Volumes in Pediatric Bipolar Disorder

2005 • 720 citations

Neuroanatomical correlates of externally and internally generated human emotion

1997 • 718 citations

The anatomy of melancholia – focal abnormalities of cerebral blood flow in major depression

1992 • 718 citations

Axis I Psychiatric Comorbidity and Its Relationship to Historical Illness Variables in 288 Patients With Bipolar Disorder

2001 • 708 citations

Switching From 'Unipolar' to Bipolar II

1995 • 695 citations

Family, twin, and adoption studies of bipolar disorder

2003 • 677 citations

Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys

1995 • 675 citations

Changes in Regional Brain Glucose Metabolism Measured With Positron Emission Tomography After Paroxetine Treatment of Major Depression

2001 • 667 citations

Neuroimaging studies of mood disorder effects on the brain

2003 • 654 citations

Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression

2000 • 651 citations

Architecture of the Prefrontal Cortex and the Central Executive

1995 • 636 citations

Brain Magnetic Resonance Imaging of Structural Abnormalities in Bipolar Disorder

1999 • 628 citations

Taste‐olfactory convergence, and the representation of the pleasantness of flavour, in the human brain

2003 • 614 citations

Enhancement of Hippocampal Neurogenesis by Lithium

2000 • 613 citations

The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review

2001 • 574 citations

Neuropsychology of bipolar disorder: a review

2002 • 569 citations

Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder

2001 • 568 citations

Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression

2004 • 546 citations

Topography of the Human Corpus Callosum

1985 • 536 citations

Reduced volume of orbitofrontal cortex in major depression

2002 • 534 citations

Neuronal and Glial Somal Size in the Prefrontal Cortex

1998 • 530 citations

Hippocampal Changes in Patients With a First Episode of Major Depression

2002 • 506 citations

Critical role of brain-derived neurotrophic factor in mood disorders

2004 • 504 citations

Representations of Pleasant and Painful Touch in the Human Orbitofrontal and Cingulate Cortices

2003 • 504 citations

Low glial numbers in the amygdala in major depressive disorder

2002 • 494 citations

Amygdala core nuclei volumes are decreased in recurrent major depression

1998 • 471 citations

Left prefrontal glucose hypometabolism in the depressed state: a confirmation

1990 • 468 citations

Quantitative Cerebral Anatomy in Depression

1993 • 458 citations

Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli

2003 • 445 citations

Activity in human ventral striatum locked to errors of reward prediction

2002 • 445 citations

Neuroplasticity Failure in Alzheimer's Disease

1999 • 442 citations

Human cortical gustatory areas

1999 • 430 citations

Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression

2005 • 421 citations

Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study

1992 • 410 citations

Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression

1998 • 401 citations

Amygdala–Hippocampal Involvement in Human Aversive Trace Conditioning Revealed through Event-Related Functional Magnetic Resonance Imaging

1999 • 400 citations

PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review

2000 • 399 citations

Depressed new Neurons?—Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression

2003 • 390 citations

Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder

2003 • 390 citations

Anterior Cingulate, Gyrus Rectus, and Orbitofrontal Abnormalities in Elderly Depressed Patients: An MRI-Based Parcellation of the Prefrontal Cortex

2004 • 378 citations

An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia

2000 • 377 citations

Quantitative MRI of the hippocampus and amygdala in severe depression

2000 • 377 citations

Volumetric reduction in left subgenual prefrontal cortex in early onset depression

2002 • 370 citations

Magnetic Resonance Imaging of the Caudate Nuclei in Depression

1992 • 361 citations

Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study

2000 • 360 citations

Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder

1997 • 358 citations

Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression

2003 • 358 citations

Decreased regional cortical gray matter volume in schizophrenia

1994 • 356 citations

Ventricular and Periventricular Structural Volumes in First- Versus Multiple-Episode Bipolar Disorder

2002 • 354 citations

Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder

2004 • 347 citations

Brain Morphometric Abnormalities in Geriatric Depression: Long-Term Neurobiological Effects of Illness Duration

2002 • 340 citations

Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression

2002 • 338 citations

Functional but not structural subgenual prefrontal cortex abnormalities in melancholia

2004 • 335 citations

Pathophysiology of obsessive–compulsive disorder

2004 • 326 citations

Metabolic rate in the right amygdala predicts negative affect in depressed patients

1998 • 320 citations

Enlargement of the amygdala in patients with a first episode of major depression

2002 • 320 citations

Lower Left Temporal Lobe MRI Volumes in Patients With First-Episode Schizophrenia Compared With Psychotic Patients With First-Episode Affective Disorder and Normal Subjects

1998 • 318 citations

The Role of the Cerebellum in Cognition and Behavior

2000 • 306 citations

Discussion

1998 • 305 citations

Subgenual Cingulate Cortex Volume in First-Episode Psychosis

1999 • 304 citations

Cytokines, stress and depressive illness: brain‐immune interactions

2003 • 303 citations

Neuroimaging in bipolar disorder

2000 • 301 citations

Regional cerebral cortical thinning in bipolar disorder

2006 • 296 citations

Regional cerebral glucose utilization in patients with a range of severities of unipolar depression

2002 • 291 citations

Neurotrophins: a family of proteins supporting the survival of neurons.

1994 • 290 citations

Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder

2001 • 286 citations

Hypercortisolemia and hippocampal changes in depression

1993 • 284 citations

Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder

1994 • 282 citations

Regional prefrontal gray and white matter abnormalities in bipolar disorder

2002 • 279 citations

Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects

2005 • 270 citations

Frontal lobe gray matter density decreases in bipolar I disorder

2004 • 269 citations

Antidepressant Treatment in Bipolar Versus Unipolar Depression

2004 • 266 citations

Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects

2003 • 264 citations

Decrease in Thalamic Volumes of Pediatric Patients With Obsessive-compulsive Disorder Who Are Taking Paroxetine

2000 • 261 citations

A magnetic resonance imaging study of putamen nuclei in major depression

1991 • 259 citations

Alterations of neuroplasticity in depression: the hippocampus and beyond

2004 • 259 citations

Frontal lobes and behaviour

1994 • 257 citations

Frontotemporal Alterations in Pediatric Bipolar Disorder

2005 • 253 citations

Reduced Amygdalar Gray Matter Volume in Familial Pediatric Bipolar Disorder

2005 • 251 citations

Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment.

1992 • 250 citations

Activation of anterior paralimbic structures during guilt-related script-driven imagery

2000 • 249 citations

Cognitive impairment and cerebral structure by MRI in bipolar disorder

1990 • 249 citations

Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor

2004 • 246 citations

Neurotrophic effects of antidepressant drugs

2003 • 245 citations

A Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder

2004 • 243 citations

Frontosubcortical Neuroanatomy and the Continuous Performance Test in Mania

1999 • 240 citations

MRI Analysis of the Cerebellum in Bipolar Disorder A Pilot Study

1999 • 237 citations

Hypofrontality and negative symptoms in major depressive disorder.

1998 • 237 citations

Magnetic Resonance Imaging and Mood Disorders

1995 • 232 citations

MRI investigation of temporal lobe structures in bipolar patients

2003 • 231 citations

Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?

2005 • 230 citations

Amygdala and hippocampus volumes in pediatric major depression

2004 • 230 citations

Reduction of orbital frontal cortex volume in geriatric depression

2000 • 229 citations

Neuroprotection and neurodegenerative disease

2002 • 227 citations

Late-Life Depression and Microstructural Abnormalities in Dorsolateral Prefrontal Cortex White Matter

2004 • 227 citations

Diagnosis-Related Regional Gray Matter Loss Over Two Years in First Episode Schizophrenia and Bipolar Disorder

2005 • 225 citations

The functional neuroanatomy of major depression

1998 • 225 citations

Hippocampal and Amygdala Changes in Patients With Major Depressive Disorder and Healthy Controls During a 1-Year Follow-Up

2004 • 221 citations

Regional Brain Morphometry in Patients With Schizophrenia or Bipolar Disorder and Their Unaffected Relatives

2006 • 220 citations

The application of positron emission tomography to the study of normal and pathologic emotions.

1997 • 219 citations

Anatomic evaluation of the orbitofrontal cortex in major depressive disorder

2003 • 215 citations

Differential Brain Metabolic Predictors of Response to Paroxetine in Obsessive-Compulsive Disorder Versus Major Depression

2003 • 213 citations

Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry

2005 • 211 citations

Implications of adult hippocampal neurogenesis in antidepressant action.

2004 • 209 citations

Structural Brain Abnormalities in Bipolar Affective Disorder

1990 • 208 citations

Structural brain abnormalities in first-episode mania

1993 • 206 citations

Differential Cerebral Metabolic Changes With Paroxetine Treatment of Obsessive-Compulsive Disorder vs Major Depression

2002 • 205 citations

Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls

1994 • 204 citations

Cell pathology in bipolar disorder

2002 • 202 citations

Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression

2004 • 201 citations

High-Dimensional Mapping of the Hippocampus in Depression

2002 • 201 citations

Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder.

1989 • 200 citations

Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses

2005 • 200 citations

Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder

2005 • 195 citations

The disconnection syndrome

1994 • 194 citations

Neuropsychological frontal lobe tests indicate that bipolar depressed patients are more impaired than unipolar

2001 • 194 citations

Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task

2004 • 194 citations

Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?

2002 • 193 citations

Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI

1998 • 193 citations

Reduced left anterior cingulate volumes in untreated bipolar patients

2004 • 190 citations

Voxel-based morphometry in adolescents with bipolar disorder: first results

2004 • 189 citations

Meta-analysis of brain and cranial size in schizophrenia

1996 • 183 citations

Clinical role of brain-derived neurotropic factor in mood disorders

2004 • 183 citations

Influence of Serotonin Transporter Promoter Region Polymorphisms on Hippocampal Volumes in Late-Life Depression

2005 • 180 citations

The Effect of Medial Frontal Cortex Lesions on Respiration, “Freezing,” and Ultrasonic Vocalizations during Conditioned Emotional Responses in Rats

1991 • 180 citations

Increased Amygdala: Hippocampal Volume Ratios Associated with Severity of Anxiety in Pediatric Major Depression

2003 • 180 citations

Voxel-based morphometry of patients with schizophrenia or bipolar disorder and their unaffected relatives

2004 • 178 citations

The Neural Network Basis for Abnormalities of Attention and Executive Function in Major Depressive Disorder: Implications for Application of the Medical Disease Model to Psychiatric Disorders

2002 • 178 citations

Hippocampal volume in early onset depression

2004 • 177 citations

Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: A pilot study

2005 • 176 citations

Reduced Hippocampal Volumes Associated With the Long Variant of theSerotonin Transporter Polymorphism in Major Depression

2004 • 174 citations

Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study

2006 • 173 citations

Changes in Gray Matter Volume in Patients with Bipolar Disorder

2005 • 171 citations

Differences and Similarities in Insular and Temporal Pole MRI Gray Matter Volume Abnormalities in First-Episode Schizophrenia and Affective Psychosis

2003 • 171 citations

A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder

2001 • 167 citations

Cognitive generation of affect in bipolar depression: an fMRI study

2004 • 167 citations

Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects

2002 • 165 citations

The hippocampus and depression

2002 • 163 citations

Decreased activation of the anterior cingulate in bipolar patients: an fMRI study

2004 • 163 citations

Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder

2004 • 162 citations

Hippocampal/amygdala volumes in geriatric depression

1999 • 155 citations

Brain Imaging Studies in Mood and Anxiety Disorders

2003 • 153 citations

Regional brain gray matter volume differences in patients with bipolar disorder as assessed by optimized voxel-based morphometry

2004 • 153 citations

Neuroimaging in bipolar disorder: what have we learned?

2000 • 153 citations

Adult brain neurogenesis and depression

2002 • 150 citations

Smaller Cingulate Volumes in Unipolar Depressed Patients

2006 • 147 citations

Neuroplasticity: from MRI to depressive symptoms

2004 • 147 citations

MRI Analysis of Cerebellar Vermal Abnormalities in Bipolar Disorder

2005 • 145 citations

MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders

2000 • 145 citations

Prefrontal Gray Matter Volume Reduction in First Episode Schizophrenia

2001 • 144 citations

Amygdala Volume Reductions in Pediatric Patients with Obsessive–Compulsive Disorder Treated with Paroxetine: Preliminary Findings

2004 • 140 citations

Cingulate Cortex Anatomical Abnormalities in Children and Adolescents With Bipolar Disorder

2005 • 140 citations

Decreased pituitary volume in patients with bipolar disorder

2001 • 139 citations

Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder

2005 • 135 citations

Interleukin‐1 in the Brain

2003 • 134 citations

State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge

2003 • 130 citations

Role of midline frontolimbic cortex in production of the isolation call of squirrel monkeys

1988 • 129 citations

Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia

1997 • 127 citations

Smaller frontal lobe white matter volumes in depressed adolescents

2002 • 126 citations

An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder

2003 • 126 citations

Chronic, treatment-resistant depression and right fronto-striatal atrophy

2002 • 126 citations

Studies of hormone action in the hippocampal formation

2002 • 124 citations

Deficits in visual cognition and attention following bilateral anterior cingulotomy

2001 • 123 citations

Contribution of Ventrolateral Prefrontal Cortex to the Acquisition and Extinction of Conditioned Fear in Rats

1999 • 121 citations

Prefrontal Cortical Volume in Childhood-Onset Major Depression

2002 • 121 citations

Occurrence of subcortical hyperintensities in elderly subjects with mania

1991 • 120 citations

A study of bipolar disorder using magnetization transfer imaging and voxel-based morphometry

2004 • 120 citations

MRI study of posterior fossa structures and brain ventricles in bipolar patients

2001 • 120 citations

Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder

2005 • 119 citations

Cortical Magnetic Resonance Imaging Findings in Familial Pediatric Bipolar Disorder

2005 • 119 citations

Temporal lobe measurement in primary affective disorder by magnetic resonance imaging

1989 • 118 citations

Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia

1989 • 117 citations

Anterior cingulate activation in high trait anxious subjects is related to altered error processing during decision making

2004 • 116 citations

Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder

2003 • 114 citations

Reduced left hemispheric white matter volume in twins with bipolar I disorder

2003 • 113 citations

White Matter Density in Patients with Schizophrenia, Bipolar Disorder and Their Unaffected Relatives

2005 • 113 citations

Cortical gray matter deficit in patients with bipolar disorder

1999 • 112 citations

Basal Ganglia Shape Alterations in Bipolar Disorder

2006 • 112 citations

The corpus callosum: Some anatomical and functional considerations with special reference to language

1974 • 109 citations

Cognitive generation of affect in hypomania: an fMRI study

2004 • 107 citations

Implications of the Neuroprotective Effects of Lithium for the Treatment of Bipolar and Neurodegenerative Disorders

2003 • 106 citations

Deficits in gray matter volume are present in schizophrenia but not bipolar disorder1This work was presented at the Meeting of the Society of Biological Psychiatry, Philadelphia, PA, USA, May 1994.1

1997 • 106 citations

Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study

2004 • 105 citations

The Role of the Cerebellum in Cognition and Behavior: A Selective Review

2000 • 105 citations

Potential behavioral modification of glucocorticoid damage to the hippocampus

1993 • 105 citations

Anatomical MRI study of corpus callosum in unipolar depression

2004 • 101 citations

Significance of Adolescent Neurodevelopment for the Neural Circuitry of Bipolar Disorder

2004 • 101 citations

Differential Effects of Age on Brain Gray Matter in Bipolar Patients and Healthy Individuals

2001 • 98 citations

Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer's disease?

1997 • 97 citations

MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals

2001 • 91 citations

Mapping brain size and cortical gray matter changes in elderly depression

2004 • 89 citations

Neurological Changes Induced by Stress in Streptozotocin Diabetic Rats

1999 • 89 citations

Structural Changes in the Brain in Depression and Relationship to Symptom Recurrence

2002 • 87 citations

Relationships between Amygdala Volume and Activity during Emotional Information Processing Tasks in Depressed and Never‐Depressed Individuals

2003 • 87 citations

Thalamic volume in pediatric obsessive–compulsive disorder patients before and after cognitive behavioral therapy

2000 • 86 citations

Antidepressant Exposure May Protect Against Decrement in Frontal Gray Matter Volumes in Geriatric Depression

2005 • 86 citations

Hippocampal changes and white matter lesions in early-onset depression

2004 • 86 citations

MRI study of the pituitary gland in adolescent depression

2003 • 84 citations

Smaller orbital frontal cortex volumes associated with functional disability in depressed elders

2003 • 84 citations

Temporal horn enlargement is present in schizophrenia and bipolar disorder

1998 • 82 citations

Caudate volume measurement in older adults with bipolar disorder

2004 • 82 citations

A quantitative magnetic resonance imaging study of cerebral and cerebellar gray matter volume in primary unipolar major depression: Relationship to treatment response and clinical severity

1997 • 80 citations

Explicit Memory and Repetition Priming in Depression

1991 • 79 citations

A quantitative magnetic resonance imaging study of caudate and lenticular nucleus gray matter volume in primary unipolar major depression: relationship to treatment response and clinical severity

1998 • 78 citations

Hippocampal Volume Measurement in Older Adults With Bipolar Disorder

2004 • 77 citations

Hyperglycemia increases brain injury caused by secondary ischemia after cortical impact injury in rats

1997 • 76 citations

Contributions from brain imaging to the elucidation of pathophysiology of bipolar disorder

2003 • 76 citations

Childhood obsessive-compulsive disorder and cingulate epilepsy

1991 • 76 citations

An MRI study of subgenual prefrontal cortex in patients with familial and non-familial bipolar I disorder

2002 • 76 citations

The Maudsley Bipolar Disorder Project

2005 • 74 citations

Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression

2003 • 74 citations

Is major depression a neurologic disorder with psychiatric symptoms?

2004 • 73 citations

Hippocampal Volume Measurement in Older Adults With Bipolar Disorder

2004 • 73 citations

Comparative analysis of the effects of four mood stabilizers in SH‐SY5Y cells and in primary neurons

2005 • 71 citations

Meta-analysis of brain size in bipolar disorder

1999 • 68 citations

Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity

1999 • 68 citations

Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls

2002 • 67 citations

Changes in Regional Cerebral Blood Flow With Venlafaxine in the Treatment of Major Depression

2003 • 66 citations

Hebb, Pandemonium and Catastrophic Hypermnesia: The Hippocampus as a Suppressor of Inappropriate Associations

2003 • 66 citations

Lack of Significant Changes on Magnetic Resonance Scans Before and After 2 Weeks of Daily Left Prefrontal Repetitive Transcranial Magnetic Stimulation for Depression

2000 • 64 citations

Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study

2005 • 60 citations

A factor model of the functional psychoses and the relationship of factors to clinical variables and brain morphology

2001 • 59 citations

Absence of Striatal Volume Differences Between Depressed Subjects With No Comorbid Medical Illness and Matched Comparison Subjects

1999 • 58 citations

The toxicity of tumor necrosis factor-α upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for alzheimer's disease

2003 • 58 citations

Developmental abnormalities in striatum in young bipolar patients: a preliminary study

2005 • 57 citations

Functional neuroimaging: enhanced understanding of migraine pathophysiology.

2000 • 57 citations

[Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives].

2002 • 55 citations

Functional organization of the circuits connecting the cerebral cortex and the basal ganglia: implications for the role of the basal ganglia in epilepsy

2002 • 54 citations

Unipolar–bipolar dichotomy of mood disorders is supported by noradrenergic brainstem system morphology

1999 • 53 citations

Structural brain changes in bipolar disorder using deformation field morphometry

2005 • 53 citations

Structural Neuroimaging Studies in Late-Life Depression: A Review

2001 • 52 citations

NMDA and AMPA receptor expression and cortical neuronal death are associated with p38 in glutamate‐induced excitotoxicity in vivo

2004 • 51 citations

Sex Differences in Brain Structure in Geriatric Depression

2004 • 50 citations

Decreased cortical gray and cerebral white matter in male patients with familial bipolar I disorder*1

2004 • 47 citations

MRI study of corpus callosum in children and adolescents with bipolar disorder

2005 • 46 citations

Normal pituitary volumes in children and adolescents with bipolar disorder: A magnetic resonance imaging study

2004 • 38 citations

Left Orbital Frontal Cortex Volume and Performance on the Benton Visual Retention Test in Older Depressives and Controls

2003 • 36 citations

Temporal lobe structure by magnetic resonance in bipolar affective disorders and schizophrenia

1991 • 35 citations

Focal lesion of the right cingulum: a case report in a child.

1981 • 33 citations

COMPARATIVE STUDIES OF THE BIOLOGICAL DISTINCTION BETWEEN UNIPOLAR AND BIPOLAR DEPRESSIONS

1997 • 31 citations

Elevated sorbitol concentration in the cerebrospinal fluid of patients with mood disorders

2000 • 28 citations

A magnetic resonance volumetric study of the temporal lobe structures in depression.

2003 • 18 citations

The Biology of Psychosis in Older People

2003 • 12 citations

Schizophrenic and Manic Brains in Nigerians Computerised Tomography Findings

1995 • 6 citations

Neuropathological studies of bipolar disorder

2000 • 4 citations