Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report

2006 • 4,724 citations

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

2006 • 3,477 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

2005 • 1,515 citations

Glial reduction in the subgenual prefrontal cortex in mood disorders

1998 • 1,497 citations

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

2005 • 1,433 citations

Astrocyte Control of Synaptic Transmission and Neurovascular Coupling

2006 • 1,266 citations

Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex

2005 • 768 citations

Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder

2001 • 754 citations

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

2000 • 690 citations

Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium

2003 • 639 citations

Reduced Neuronal Size and Glial Cell Density in Area 9 of the Dorsolateral Prefrontal Cortex in Subjects with Major Depressive Disorder

2002 • 620 citations

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

2005 • 617 citations

Gliogenesis and Glial Pathology in Depression

2007 • 580 citations

Increased Levels of Glutamate in Brains from Patients with Mood Disorders

2007 • 578 citations

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

2008 • 552 citations

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

2003 • 494 citations

Astrocytes: Glutamate producers for neurons

1999 • 438 citations

Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment

2005 • 426 citations

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

2006 • 400 citations

Stress Effects on Morphology and Function of the Hippocampus^a

1997 • 393 citations

Altered Expression and Uptake Activity of Spinal Glutamate Transporters after Nerve Injury Contribute to the Pathogenesis of Neuropathic Pain in Rats

2003 • 390 citations

Transporters for<scp>L</scp>‐glutamate: An update on their molecular pharmacology and pathological involvement

2006 • 368 citations

Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by¹³C Nuclear Magnetic Resonance Spectroscopy: Elucidation of the Dominant Pathway for Neurotransmitter Glutamate Repletion and Measurement of Astrocytic Oxidative Metabolism

2002 • 367 citations

Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment

2006 • 344 citations

Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat

2007 • 329 citations

Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder

2000 • 327 citations

In vivo ¹³ C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling

1997 • 315 citations

Beyond Monoamines: Glutamatergic Function in Mood Disorders

2005 • 287 citations

Age-Dependent Reductions in the Level of Glial Fibrillary Acidic Protein in the Prefrontal Cortex in Major Depression

2004 • 250 citations

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus

2001 • 247 citations

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1

2007 • 237 citations

Riluzole Enhances Glutamate Uptake in Rat Astrocyte Cultures

2004 • 202 citations

Behavioral Stress Enhances Hippocampal CA1 Long-Term Depression through the Blockade of the Glutamate Uptake

2005 • 180 citations

Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes

2000 • 178 citations

Riluzole in the Treatment of Mood and Anxiety Disorders

2008 • 166 citations

Regulation of Neurogenesis and Gliogenesis by Stress and Antidepressant Treatment

2007 • 164 citations

Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking

2004 • 145 citations

Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice

2006 • 140 citations

In vivo ^ C NMR measurements of cerebral synthesis as evidence for glutamate-glutamine cycling

1997 • 107 citations

Pro-survival signalling from the NMDA receptor

2006 • 98 citations

Glutamatergic and GABAergic Neurotransmitter Cycling and Energy Metabolism in Rat Cerebral Cortex during Postnatal Development

2007 • 84 citations

Shuttle-box deficits induced by chronic variable stress: Reversal by imipramine administration

1991 • 73 citations

Effect of stress on prefrontal cortex function

2004 • 71 citations

Compartmentalized NMDA receptor signalling to survival and death

2007 • 62 citations

Electroconvulsive seizure increases adult hippocampal angiogenesis in rats

2006 • 57 citations

Glial Modulation of GABAergic and Glutamat ergic Neurotransmission

2006 • 55 citations

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase‐deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

2007 • 53 citations

Astrocytes and Synaptosomes Transport and Metabolize Lactate and Acetate Differently

2003 • 32 citations

The metabotropic glutamate receptor subtype 5 antagonist MPEP and the Na+ channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions

2005 • 25 citations

Neuroprotective Agents: Is Effective on Toxicity in Glial Cells?

2006 • 13 citations