Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

ECDEU Assessment Manual

1976 • 1,644 citations

Tardive Dyskinesia

1982 • 660 citations

Tardive dystonia

1982 • 605 citations

Spontaneous Involuntary Disorders of Movement

1982 • 338 citations

Changes in Prevalence, Severity, and Recovery in Tardive Dyskinesia With Age

1980 • 308 citations

An experimental model of tardive dyskinesia

1972 • 276 citations

Primate models of dyskinesia: The experimental approach to the study of basal ganglia-related involuntary movement disorders

1987 • 276 citations

Dopaminergic supersensitivity after neuroleptics: Time-course and specificity

1978 • 271 citations

Neural mechanisms in disorders of movement

1989 • 270 citations

Understanding and Treating Tardive Dyskinesia

1983 • 269 citations

Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis

1984 • 252 citations

Induction of oral dyskinesias in naive rats by D1 stimulation

1983 • 250 citations

Acute dystonia induced by neuroleptic drugs

1986 • 220 citations

Neurobiological substrates of tardive dyskinesia: the GABA hypothesis

1984 • 209 citations

Integrating incidence and prevalence of tardive dyskinesia.

1986 • 209 citations

Spontaneous Orofacial Dyskinesia and Dopaminergic Function in Rats After 6 Months of Neuroleptic Treatment

1983 • 193 citations

3H-spiperone binding sites in post-mortem brains from schizophrenic patients: Relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms

1989 • 189 citations

Tardive dyskinesia

1988 • 162 citations

Changes in dopamine-mediated behaviour during one year's neuroleptic administration

1979 • 160 citations

Therapeutic Strategies Against Tardive Dyskinesia

1982 • 159 citations

Cognitive Dysfunction, Negative Symptoms, and Tardive Dyskinesia in Schizophrenia

1987 • 155 citations

Tardive Dyskinesia: Prevalence, Incidence, and Risk Factors

1985 • 151 citations

Reduction of nigral glutamic acid decarboxylase in rats with neuroleptic-induced oral dyskinesia

1983 • 140 citations

A Study of Facial Dyskinesia in a Mental Hospital Population

1971 • 139 citations

Biological psychiatry

1987 • 132 citations

Dyskinesia. Research and treatment.

1985 • 126 citations

Oral dyskinesia in rats following brain lesions and neuroleptic drug administration

1982 • 118 citations

Cerebral dopamine function in rats following withdrawal from one year of continuous neuroleptic administration

1980 • 116 citations

Pharmacological characterisation of spontaneous or drug-associated purposeless chewing movements in rats

1985 • 113 citations

The effect of chronic neuroleptic administration on cerebral dopamine receptor function

1983 • 113 citations

Brain γ-Aminobutyric Acid Abnormality in Tardive Dyskinesia

1987 • 112 citations

Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats

1983 • 111 citations

Schizophrenia, Affective Psychoses, and Other Disorders Treated with Neuroleptic Drugs: The Enigma of Tardive Dyskinesia, Its Neurobiological Determinants, and the Conflict of Paradigms

1989 • 99 citations

Understanding and treating tardive dyskinesia

1983 • 99 citations

Spontaneous chewing movements in rats during acute and chronic antipsychotic drug administration

1986 • 98 citations

Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat

1985 • 93 citations

Neuroleptic-induced oral dyskinesias: effects of progabide and lack of correlation with regional changes in glutamic acid decarboxylase and choline acetyltransferase activities

1987 • 84 citations

Striatal dopamine D2 receptors in tardive dyskinesia: PET study.

1989 • 77 citations

Rats administered chronic neuroleptics develop oral movements which are similar in form to those in humans with tardive dyskinesia

1989 • 77 citations

Tardive Dyskinesia in the Aged

1985 • 75 citations

Tremorous mouth movements in rats administered chronic neuroleptics

1987 • 68 citations

The Neurobiology of Dopamine Systems

1987 • 68 citations

Chronic pharmacological manipulation of dopamine receptors in brain

1987 • 65 citations

Tardive dyskinesia in schizophrenia and other disorders: Associations with ageing, cognitive dysfunction and structural brain pathology in relation to neuroleptic exposure

1987 • 64 citations

Oral dyskinesia in brain-damaged rats withdrawn from a neuroleptic: Implication for models of tardive dyskinesia

1980 • 62 citations

Association of intellectual impairment, negative symptoms, and aging with tardive dyskinesia: clinical and animal studies.

1985 • 61 citations

Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat

1984 • 59 citations

Neuroleptic-induced oral movements in rats: Methodological issues

1987 • 57 citations

Behavioral consequences of long-term treatment with neuroleptic drugs.

1980 • 57 citations

Chronic neuroleptic treatment in rats produces persisting changes in GABAA and dopamine D-2, but not dopamine D-1 receptors

1989 • 56 citations

Tardive Dyskinesia: Reversible and Irreversible

1985 • 51 citations

Anticholinergic Challenge and Neuroleptic Withdrawal

1984 • 48 citations

The Reversibility of “Permanent” Tardive Dyskinesia

1984 • 47 citations

Chronic neuroleptics alter the effects of the D1 agonist SK&F 38393 and the D2 agonist LY171555 on oral movements in rats

1988 • 47 citations

Extraversion and the EEG: I. An evaluation of Gale's hypothesis

1984 • 45 citations

Pharmacologic Characterization of Tardive Dyskinesia

1988 • 44 citations

Chronic haloperidol effects on oral movements and radial-arm maze performance in rats

1987 • 43 citations

Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia

1989 • 42 citations

Dose-dependent increases in rat spontaneous chewing rates during long-term administration of haloperidol but not clozapine

1986 • 37 citations

Drug holidays alter onset of oral movements in rats following chronic haloperidol.

1984 • 35 citations

Characteristics of oral movements in rats during and after chronic haloperidol and fluphenazine administration

1988 • 33 citations

Recent Research in Neurology

1985 • 32 citations

Intermittent neuroleptic treatment induces long-lasting abnormal mouthing in the rat

1989 • 30 citations

Involuntary Disorders of Movement in Chronic Schizophrenia — The Role of the Illness and Its Treatment

1985 • 28 citations

Involuntary orofacial movements in hospitalised patients with mental handicap or epilepsy: relationship to developmental/intellectual deficit and presence or absence of long-term exposure to neuroleptics.

1988 • 28 citations

Chemical and Structural Changes in the Brain in Patients with Movement Disorder

1985 • 26 citations

Is the dopamine hypothesis of tardive dyskinesia completely wrong?

1986 • 25 citations

Diminished D2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements

1988 • 25 citations

Schizophrenia, tardive dyskinesia, and brain GABA

1989 • 24 citations

The Lifetime Outcome and Involuntary Movements of Schizophrenia Never Treated with Neuroleptic Drugs

1990 • 23 citations

Perioral behaviors induced by cholinesterase inhibitors: A controversial animal model

1986 • 17 citations

Interaction between chronic amphetamine and neuroleptic treatments on oral behavior in rats

1987 • 14 citations

The pathophysiology of tardive dyskinesia.

1985 • 13 citations

Dyskinesia, antipsychotic-drug exposure and risk factors in a developmentally-disabled population

1988 • 12 citations

Fluphenazine-induced acute and tardive dyskinesias in monkeys

1984 • 12 citations

Tardive dyskinesia: natural history studies assist the pursuit of preventive therapies

1986 • 9 citations

Dopamine receptor function and spontaneous orofacial dyskinesia in rats during 6-month neuroleptic treatments.

1983 • 7 citations

Reply from Waddington

1986 • 4 citations

Methodological issues in PET scan evaluation of dopamine supersensitivity in tardive dyskinesia

1989 • 3 citations

Post-mortem neurochemical studies of tardive dyskinesia

1989 • 2 citations

Post-mortem neurochemical studies of tardive dyskinesia

1990 • 2 citations

Deleted Work

1955 • 0 citations