Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxinN-methyl-4-phenylpyridinium (MMP+) towards cultured dopaminergic neuroblastoma cells

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics.

1986 • 1,091 citations

Dopamine receptors and the dopamine hypothesis of schizophrenia

1987 • 867 citations

Drugs and the treatment of psychiatric disorders

1996 • 581 citations

Coordinate Morphological and Biochemical Interconversion of Human Neuroblastoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1983 • 544 citations

Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and N‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System

1992 • 465 citations

MPTP Toxicity: Implications for Research in Parkinson's Disease

1988 • 287 citations

Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia

1990 • 242 citations

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1991 • 215 citations

3H-spiperone binding sites in post-mortem brains from schizophrenic patients: Relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms

1989 • 189 citations

Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP

1986 • 179 citations

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium

1993 • 171 citations

Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats

1990 • 132 citations

Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment

1989 • 118 citations

Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite

1991 • 94 citations

1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies.

1994 • 66 citations

On the metabolism of haloperidol

1993 • 65 citations

Tardive Dyskinesia, Dopamine Receptors, and Neuroleptic Damage to Cell Membranes

1988 • 59 citations

Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite

1991 • 53 citations

Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rats

1990 • 51 citations

High-performance liquid chromatographic method for the detection and quantitation of haloperidol and seven of its metabolites in microsomal preparations

1993 • 48 citations

Determination of the pyridinium metabolite derived from haloperidol in brain tissue, plasma and urine by high-performance liquid chromatography with fluorescence detection

1992 • 28 citations

Extrapyramidal Symptoms in Neuroleptic Recipients

1990 • 28 citations

One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists.

1990 • 20 citations

One year treatment with haloperidol or clozapine fails to alter neostriatal D1- and D2-dopamine receptor sensitivity in the rat

1989 • 18 citations

Effect of Nerve Growth Factor on Catecholamine Metabolism in a Human Neuroblastoma Clone (SY5Y)

1982 • 18 citations

Investigation of the neuroleptic drug haloperidol and its metabolites using tandem mass spectrometry

1992 • 17 citations

Local glial reaction in the CNS of albino-rats in response to the administration of a neuroleptic drug (butyrophenone).

1967 • 15 citations

Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats

1993 • 10 citations

Synaptic Changes in the Rabbit Pallidum Following Long‐Term Haloperidol Administration

1973 • 8 citations

MPP+-LIKE NEUROTOXICITY OF HPP+, A PYRIDINIUM METABOLITE OF HALOPERIDOL - A MICRODIALYSIS STUDY

1991 • 4 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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