Modulation of NMDA effects on agonist‐stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1989 • 347 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1989 • 251 citations

Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands

1983 • 226 citations

Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: Effects of neurotransmitters and depolarization

1988 • 217 citations

An essential role for phosphatidylinositol transfer protein in phospholipase C-Mediated inositol lipid signaling

1993 • 205 citations

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

1991 • 161 citations

Neuroprotective effect of memantine demonstrated in vivo and in vitro

1990 • 157 citations

Efficacy and tolerability of memantine in patients with dementia syndrome. A double-blind, placebo controlled trial.

1991 • 124 citations

Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study.

1992 • 121 citations

Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate

1991 • 106 citations

Wirkungen oraler Memantin-Gaben auf die Parkinson-Symptomatik: Ergebnisse einer placebo-kontrollierten Multicenter-Studie

2008 • 95 citations

Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity

1992 • 84 citations

NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine

1993 • 78 citations

Inhibitory effects of the antiparkinsonian drugs memantine and amantadine on N-methyl-D-aspartate-evoked acetylcholine release in the rabbit caudate nucleus in vitro.

1992 • 74 citations

Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations

1989 • 69 citations

Interactions Between Phospholipase C‐Coupled and N‐Methyl‐D‐Aspartate Receptors in Cultured Cerebellar Granule Cells: Protein Kinase C Mediated Inhibition of N‐Methyl‐D‐Aspartate Responses

1992 • 67 citations

Memantine prevents quinolinic acid-induced hippocampal damage

1992 • 55 citations

Regulation of the metabolism of 1,2-diacyglycerols and inositol phasphates that respond to receptor activation

1991 • 50 citations

[Pharmacodynamics and pharmacokinetics of memantine].

1983 • 48 citations

Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R‐ACPD in neonatal rat cerebral cortex

1994 • 45 citations

Pharmacological effects of 1,3-dimethyl-5-aminoadamantane, a new adamantane derivative

1974 • 41 citations

Neurochemistry: a Practical Approach

1988 • 40 citations

Manganese Stimulates the Incorporation of [³H]Inositol into a Pool of Phosphatidylinositol in Brain That Is Not Coupled to Agonist‐Induced Hydrolysis

1985 • 37 citations

Memantine stimulates inositol phosphates production in neurones and nullifies N- destruction of retinal neurones

1992 • 35 citations

Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-d-aspartate in neonatal rat cerebral cortex

1994 • 25 citations

Stimulatory and Inhibitory Effects of N-Methyl-D-Aspartate on3H-Inositol Polyphosphate Accumulation in Rat Cortical Slices

1991 • 24 citations

The effect of MnCl₂ on the basal and acetylcholine‐stimulated turnover of phosphatidylinositol in synaptosomes

1979 • 24 citations

Evidence for coupling of resynthesis to hydrolysis in the phosphoinositide cycle

1991 • 23 citations

[Memantine and neurogenic bladder disorders within the bounds of spastic conditions].

1982 • 17 citations

[Effect of memantine on central neurotransmitter systems. Review of the results].

1982 • 10 citations

Measurement of Inositol 1,4,5-Trisphosphate, Inositol 1,3,4,5-Tetrakisphosphate, and Phosphatidylinositol 4,5-Bisphosphate in Brain

1993 • 9 citations