Analysis and origins of the human and mouse RNase L genes: mediators of interferon action

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response

1997 • 886 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

1993 • 509 citations

A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

1993 • 273 citations

A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System

1997 • 262 citations

2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A

1995 • 259 citations

The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis

1998 • 178 citations

Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells

1997 • 137 citations

A Bipartite Model of 2-5A-dependent RNase L

1997 • 112 citations

2-5A-Dependent RNase L

1997 • 85 citations

Impact of RNase L Overexpression on Viral and Cellular Growth and Death

1998 • 74 citations

Stoichiometry of 2′,5′-Oligoadenylate-induced Dimerization of Ribonuclease L

1996 • 62 citations

Alternative function of a protein kinase homology domain in 2',5'-oligoadenylate dependent RNase L

1999 • 61 citations

A hybrid protein kinase‐RNase in an interferon‐induced pathway?

1993 • 53 citations

Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats.

1994 • 33 citations

Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

1995 • 31 citations

Localization of the Interferon-Induced, 2-5A-Dependent RNase Gene (RNS4) to Human Chromosome 1q25

1994 • 28 citations