Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-α in Chronic Myelogenous Leukemia

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage

1977 • 888 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

Interferon Alfa-2a as Compared with Conventional Chemotherapy for the Treatment of Chronic Myeloid Leukemia

1994 • 592 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro

1995 • 505 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

1987 • 461 citations

Interferon-Alpha Produces Sustained Cytogenetic Responses in Chronic Myelogenous Leukemia

1991 • 398 citations

Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients

1982 • 381 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells.

1983 • 373 citations

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C

1994 • 363 citations

BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents

1995 • 363 citations

Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells

1993 • 319 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV.

1992 • 263 citations

Involvement of the B-lymphoid system in chronic myelogenous leukaemia

1980 • 240 citations

Interferon‐γ and tumor necrosis factor‐α suppress both early and late stages of hematopoiesis and induce programmed cell death

1995 • 232 citations

Functional expression of Fas antigen (CD95) on hematopoietic progenitor cells

1995 • 188 citations

APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expression

1993 • 178 citations

Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages

1995 • 175 citations

Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583 [see comments]

1993 • 170 citations

Functional expression of Fas antigen (CD95) on hematopoietic progenitor cells

1995 • 149 citations

Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation: implications for graft-versus-leukemia reactivity

1995 • 131 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 131 citations

Characterization of human Fas gene. Exon/intron organization and promoter region.

1995 • 130 citations

Interferon-alpha overrides the deficient adhesion of chronic myeloid leukemia primitive progenitor cells to bone marrow stromal cells

1991 • 117 citations

Functional Consequences of APO-1/Fas (CD95) Antigen Expression by Normal and Neoplastic Hematopoietic Cells

1995 • 98 citations

Regulation of cytokine expression by interferon-alpha in human bone marrow stromal cells: inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist

1994 • 94 citations

Incidence of involvement of the B and T lymphocyte lineages in chronic myelogenous leukemia

1985 • 88 citations

Expression and function of Fas (APO-1/CD95) in patient myeloma cells and myeloma cell lines

1995 • 88 citations

Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells.

1991 • 85 citations

Detection of minimal residual disease by polymerase chain reaction in Philadelphia chromosome-positive chronic myelogenous leukemia following interferon therapy

1992 • 83 citations

Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X‐irradiation and glucocorticoids

1995 • 82 citations

Fas/APO-1 Expression and Function on Malignant Cells of Hematologic and Nonhematologic Origin

1993 • 78 citations

Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients

1995 • 75 citations

Alteration in bone marrow adherent layer growth factor expression: a novel mechanism of chronic myelogenous leukemia progression

1991 • 67 citations

Expression and modulation of cellular receptors for interferon‐γ, tumour necrosis factor, and Fas on human bone marrow CD34⁺ cells

1997 • 66 citations

BCR-ABL does not prevent apoptotic death induced by human natural killer or lymphokine-activated killer cells

1996 • 62 citations

Treatment of marrow stroma with interferon-alpha restores normal beta 1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors. Role of MIP-1 alpha.

1995 • 62 citations

Hematopoietic inhibition by interferon-gamma is partially mediated through interferon regulatory factor-1

1995 • 50 citations

Expression of the Fas antigen on primary human leukemia cells

1995 • 45 citations

BCR-ABL: An Anti-Apoptosis Gene in Chronic Myelogenous Leukemia

1995 • 36 citations

Cellular and cytokine-mediated effects of CD4-positive lymphocyte lines generated in vitro against chronic myelogenous leukemia.

1995 • 34 citations

The function of lymphocytes in normal and suppressed hematopoiesis

1984 • 34 citations

The effects of interferon‐α on the proliferation of CML progenitor cells in vitro are not related to the precise position of the M‐BCR breakpoint

1991 • 31 citations

Recombinant interferon-alpha-2C in chronic myelogenous leukaemia: Relationship of sensitivity of committed haematopoietic precursor cells in vitro (BFU-E, CFU-GM, CFU-Meg) and clinical response

1990 • 20 citations

Induction of interferon regulatory factors, 2′‐5′ oligoadenylate synthetase, P68 kinase and RNase L in chronic myelogenous leukaemia cells and its relationship to clinical responsiveness

1996 • 19 citations

Bone marrow progenitor cells induce a regulatory autologous proliferative T lymphocyte response.

1989 • 18 citations

Incidence of involvement of the B and T lymphocyte lineages in chronic myelogenous leukemia

1985 • 5 citations