IFN‐γupregulates apoptosis‐related molecules and enhances Fas‐mediated apoptosis in human cholangiocarcinoma

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

1998 • 857 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

The Role of c-FLIP in Modulation of CD95-induced Apoptosis

1999 • 823 citations

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

1998 • 752 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

1998 • 461 citations

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

1996 • 425 citations

Human lung carcinomas express Fas ligand.

1997 • 395 citations

Fas-mediated cytotoxicity by freshly isolated natural killer cells.

1995 • 372 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression.

1998 • 283 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

Histopathological Evaluation of Apoptosis in Cancer

1998 • 245 citations

Fas expression and function in normal and malignant breast cell lines.

1996 • 236 citations

Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment

1999 • 232 citations

Interferon γ Induces Upregulation and Activation of Caspases 1, 3, and 8 to Produce Apoptosis in Human Erythroid Progenitor Cells

1999 • 206 citations

Expression Analysis of the Human Caspase-1 Subfamily Reveals Specific Regulation of the CASP5 Gene by Lipopolysaccharide and Interferon-γ

2000 • 183 citations

NFκB Mediates Apoptosis through Transcriptional Activation of Fas (CD95) in Adenoviral Hepatitis

2000 • 165 citations

Thymineless death in colon carcinoma cells is mediated via Fas signaling

1997 • 162 citations

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

1999 • 159 citations

Fas/APO-1 gene transfer for human malignant glioma.

1995 • 127 citations

Human and Mouse Fas (APO-1/CD95) Death Receptor Genes Each Contain a p53-responsive Element That Is Activated by p53 Mutants Unable to Induce Apoptosis

2000 • 124 citations

Interferon-activated signal transduction to the nucleus

1994 • 108 citations

Vascular endothelial platelet endothelial adhesion molecule-1 (PECAM-1) expression is decreased by TNF-alpha and IFN-gamma. Evidence for cytokine-induced destabilization of messenger ribonucleic acid transcripts in bovine endothelial cells.

1996 • 107 citations

Lack of cell surface Fas/APO-1 expression in pulmonary adenocarcinomas.

1998 • 91 citations

Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells

1997 • 90 citations

Potentiation of Fas-Mediated Apoptosis of Murine Granulosa Cells by Interferon-γ, Tumor Necrosis Factor-α, and Cycloheximide**This work was supported by NIH Grant HD-32535.

1998 • 86 citations

Inflammatory Cytokine Regulation of Fas-mediated Apoptosis in Thyroid Follicular Cells

1999 • 83 citations

Up-regulation of Fas Ligand at Early Stages and Down-regulation of Fas at Progressed Stages of Intrahepatic Cholangiocarcinoma Reflect Evasion From Immune Surveillance

2000 • 72 citations

Surgical treatment of cholangiocarcinoma.

1997 • 69 citations

Cholangiocarcinomas express fas ligand and disable the fas receptor

1999 • 69 citations

Heterogenous susceptibility to CD95-induced apoptosis in melanoma cells correlates with bcl-2 and bcl-x expression and is sensitive to modulation by interferon-?

1999 • 62 citations

Tamoxifen-mediated growth inhibition of human cholangiocarcinoma.

1997 • 59 citations

Apoptosis and Tumorigenesis in Human Cholangiocarcinoma Cells

1999 • 56 citations

Evidence for gene silencing by endogenous DNA methylation

1998 • 52 citations

DNA methylation: regulation of gene expression and role in the immune system

1997 • 48 citations

Regulation of CD95 (APO-1/ FAS) ligand and receptor expression in squamous-cell carcinoma by interferon-? and cisplatin

1999 • 39 citations

Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma

2000 • 28 citations

Potentiation of Fas-Mediated Apoptosis of Murine Granulosa Cells by Interferon- , Tumor Necrosis Factor- , and Cycloheximide

1998 • 27 citations

Fas expression prevents cholangiocarcinoma tumor growth

1999 • 15 citations

[Intrahepatic bile duct carcinoma (cholangiocarcinoma)].

1997 • 12 citations

Loss of Fas (CD95/APO-1) Expression by Antigen-Specific Cytotoxic T Cells Is Reversed by Inhibiting DNA Methylation

2000 • 10 citations