Potential for protein kinase C inhibitors in cancer therapy

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Anti-cancer Drug Design

2018 • 1,309 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Isolation and structure of bryostatin 1

1982 • 638 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

Inhibition of protein kinase C by tamoxifen.

1985 • 464 citations

The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes

1986 • 460 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor α, interleukin 1 and phorbol ester

1993 • 388 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Signal transduction via phosphatidylcholine cycles

1989 • 314 citations

The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation

1992 • 265 citations

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

1990 • 262 citations

Selective translocation of beta II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.

1991 • 251 citations

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.

1994 • 237 citations

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1987 • 228 citations

Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen.

1984 • 227 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Balanol: a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides

1993 • 205 citations

T‐Lymphocyte Activation: The Role of Protein Kinase C and the Bifurcating Inositol Phospholipid Signal Transduction Pathway

1987 • 203 citations

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

1990 • 200 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

Phase I Study of Bryostatin 1: Assessment of Interleukin 6 and Tumor Necrosis Factor Induction In Vivo

1993 • 185 citations

Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells

1988 • 183 citations

Protein kinase C and T cell activation

1990 • 183 citations

Activation of the PKC‐isotypes α, β₁, γ, δ, and ε by phorbol esters of different biological activities

1991 • 178 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor

1985 • 167 citations

Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.

1993 • 166 citations

Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.

1988 • 166 citations

Antineoplastic Components of Marine Animals

1970 • 162 citations

Protein kinase C: is its pivotal role in cellular activation over-stated?

1994 • 161 citations

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.

1989 • 156 citations

The Large-Scale Isolation of Bryostatin 1 from Bugula neritina Following Current Good Manufacturing Practices

1991 • 154 citations

A phase I study of intravenous bryostatin 1 in patients with advanced cancer

1993 • 147 citations

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 • 146 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Protein Kinase C: A Novel Target for Inhibiting Gastric Cancer Cell Invasion

1993 • 142 citations

Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin

1983 • 142 citations

Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation.

1991 • 138 citations

A role for phospholipase D in control of mitoqenesis

1994 • 137 citations

Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity.

1992 • 133 citations

The assembly of signalling complexes by receptor tyrosine kinases

1993 • 130 citations

Biology of the protein kinase C family

1989 • 120 citations

Enhancement of the antiproliferative effect of cis‐diamminedichloroplatinum(II) and nitrogen mustard by inhibitors of protein kinase C

1988 • 120 citations

Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists.

1992 • 118 citations

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

1992 • 111 citations

Cell surface actions of adriamycin

1991 • 109 citations

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation.

1989 • 107 citations

Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.

1992 • 104 citations

Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.

1987 • 104 citations

Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells

1990 • 98 citations

Effects of biologically active metabolites of tamoxifen on the proliferation kinetics of MCF-7 human breast cancer cells in vitro.

1983 • 95 citations

Bryostatin 1, a unique biologic response modifier: anti-leukemic activity in vitro

1990 • 95 citations

Longwave ultraviolet radiation and promotion of skin cancer.

1991 • 94 citations

Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells.

1992 • 94 citations

Successful treatment of murine melanoma with bryostatin 1.

1991 • 94 citations

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

1994 • 92 citations

Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.

1992 • 91 citations

ChemInform Abstract: ISOLATION AND STRUCTURE OF BRYOSTATIN 1

1983 • 91 citations

Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum(II).

1990 • 91 citations

Effects of suramin, an anti-human immunodeficiency virus reverse transcriptase agent, on protein kinase C. Differential activation and inhibition of protein kinase C isozymes.

1990 • 88 citations

Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells.

1993 • 87 citations

Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-d-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells

1994 • 86 citations

Human Multidrug Resistant KB Cells Overexpress Protein Kinase C: Involvement in Drug Resistance

1989 • 82 citations

Towards selective pharmacological modulation of protein kinase C – opportunities for the development of novel antineoplastic agents

1992 • 81 citations

Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.

1987 • 80 citations

Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells.

1993 • 79 citations

Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins.

1988 • 76 citations

Phorbol Ester-Induced, Cell-Cycle-Specific, Growth Inhibition of Human B-Lymphoma Cell Lines

1990 • 74 citations

Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1.

1992 • 73 citations

Inhibition of MCF-7 cell growth by 12-O-tetradecanoylphorbol-13-acetate and 1,2-dioctanoyl-sn-glycerol: distinct effects on protein kinase C activity.

1988 • 71 citations

The design and biological properties of potent and selective inhibitors of protein kinase C

1992 • 71 citations

Basic fibroblast growth factor requires a long-lasting activation of protein kinase C to induce cell proliferation in transformed fetal bovine aortic endothelial cells.

1991 • 70 citations

Activation of human T lymphocytes by bryostatin.

1988 • 70 citations

Bryostatin 1, a unique biologic response modifier: anti-leukemic activity in vitro

1990 • 70 citations

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.

1992 • 69 citations

Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain

1988 • 68 citations

Failure of wild-type or a mutant form of protein kinase C-α to transform fibroblasts

1991 • 68 citations

Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes.

1987 • 67 citations

Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro

1988 • 65 citations

The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF‐7 breast carcinoma cells

1994 • 63 citations

Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.

1983 • 61 citations

Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells

1989 • 61 citations

Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells

1989 • 58 citations

New insights into protein‐tyrosine kinase receptor signaling complexes

1993 • 58 citations

RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages

1991 • 57 citations

Damage to DNA by UV light and activation of transcription factors

1994 • 56 citations

Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells.

1987 • 56 citations

Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation

1993 • 56 citations

Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.

1992 • 56 citations

Interleukin‐1β induction of TNF‐α gene expression: Involvement of protein kinase C

1992 • 55 citations

Protein kinase C-γ is present in adriamycin resistant HL-60 leukemia cells

1990 • 53 citations

Differential expression of protein kinase C ɛ protein in lung cancer cell lines by ionising radiation

1992 • 50 citations

Intracellular signalling mediated by protein-tyrosine kinases: Networking through phospholipid metabolism

1993 • 49 citations

Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents.

1994 • 49 citations

Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells

1989 • 49 citations

Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C

1991 • 48 citations

Protein kinase C--a novel target for rational anti-cancer drug design?

1989 • 43 citations

Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate.

1991 • 43 citations

Stimulated phosphatidylcholine hydrolysis as a signal transduction pathway in mitogenesis

1991 • 43 citations

In vivo administration of the anticancer agent bryostatin 1 activates platelets and neutrophils and modulates protein kinase C activity.

1993 • 43 citations

Protein kinase C isoforms in multidrug resistant P388/ADR cells: a possible role in daunorubicin transport

1992 • 42 citations

Type beta 1 transforming growth factor gene expression. A corrected mRNA structure reveals a downstream phorbol ester responsive element in human cells.

1990 • 42 citations

The action of bryostatin on normal human hematopoietic progenitors is mediated by accessory cell release of growth factors

1990 • 40 citations

Effects of Suramin, an Anti-human Immunodeficiency Virus Reverse Transcriptase Agent, on Protein Kinase C

1990 • 38 citations

Transmembrane signalling by the B-cell antigen receptor

1994 • 38 citations

Protein kinase C modulation.

1992 • 38 citations

Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin.

1992 • 34 citations

Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha.

1992 • 33 citations

ENHANCED EXPRESSION OF PROTEIN KINASE C GENE CAUSED BY SOLAR RADIATION

1991 • 31 citations

Protein Kinase C-α But Not Protein Kinase C-ϵ Is Differentially Down-Regulated by Bryostatin 1 and Tetradecanoyl Phorbol 13-Acetate in SH-SY5Y Human Neuroblastoma Cells

1993 • 31 citations

Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia.

1991 • 30 citations

Stable expression of a cDNA encoding rat brain protein kinase C-beta I confers a multidrug-resistant phenotype on rat fibroblasts.

1992 • 28 citations

Phorbol ester and bryostatin effects on growth and the expression of oestrogen responsive and TGF-β1 genes in breast tumour cells

1991 • 28 citations

Protein kinase C regulates both production and secretion of interleukin 2

1991 • 26 citations

Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin.

1990 • 26 citations

Bryostatin 1-Induced Modulation of the Acute Lymphoblastic Leukemia Cell Line Reh

1993 • 25 citations

Activation signals in human lymphocytes: Interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C

1990 • 24 citations

Differentiation and Growth Modulation of Myeloid Leukemia Cells by the Protein Kinase C Activating Agent Bryostatin-1

1993 • 24 citations

Effect of pharmacologic manipulation of protein kinase C by phorbol dibutyrate and bryostatin 1 on the clonogenic response of human granulocyte‐macrophage progenitors to recombinant GM‐CSF

1991 • 23 citations

Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells

1993 • 22 citations

Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells

1991 • 22 citations

Bryostatin 1-activated T cells can traffic and mediate tumor regression

1992 • 21 citations

Protein kinase C activities and bindings of a phorbol ester tumor promoter in 41 cell lines

1988 • 20 citations

Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1.

1988 • 19 citations

In vitro effects of bryostatin 1 on the metabolism and cytotoxicity of 1-β-d-arabinofuranosylcytosine in human leukemia cells

1991 • 19 citations

Overcoming of vinblastine resistance by isoquinolinesulfonamide compounds in adriamycin-resistant leukemia cells.

1992 • 18 citations

Alteration of human lymphokine-activated killer cell activity by manipulation of protein kinase C and cytosolic Ca2+.

1988 • 17 citations

Activation of T-cells by bryostatins: Induction of the IL-2 receptor gene transcription and down-modulation of surface receptors

1990 • 17 citations

Enhancement of sensitivity to platinum(II)-containing drugs by 12-O-tetradecanoyl-phorbol-13-acetate in a human ovarian carcinoma cell line

1994 • 17 citations

Conversion of high grade lymphoma tumor cell line to intermediate grade with tpa and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis

1990 • 17 citations

Regulation of hematopoiesis-IV: The role of interleukin-3 and bryostatin 1 in the growth of erythropoietic progenitors from normal and anemic W/Wv mice

1988 • 16 citations

Antiproliferative effect of phorbol esters on MCF-7 human breast adenocarcinoma cells: Relationship with enhanced expression of transforming growth-factor-β1

1992 • 14 citations

Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin.

1992 • 14 citations

Adriamycin interacts with diacylglycerol to inhibit human leukemia protein kinase C.

1989 • 14 citations

Localization of Protein Kinase C in Skeletal Muscle T-Tubule Membranes

1993 • 14 citations

Effects of bryostatin 1 and rGM‐CSF on the metabolism of 1‐β‐<scp>d</scp>‐arabinofuranosylcytosine in human leukaemic myeloblasts

1992 • 11 citations

Synthesis of diacylglycerol analogues as potential second-messenger antagonists and inhibitors of protein kinase C

1992 • 10 citations

Verapamil decreases lymphocyte protein kinase C activity in humans

1994 • 10 citations

Toxicity of phorbol esters for human epithelial cells expressing a mutant ras Oncogene

1993 • 4 citations