Basic fibroblast growth factor requires a long-lasting activation of protein kinase C to induce cell proliferation in transformed fetal bovine aortic endothelial cells.

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells

1987 • 387 citations

Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence

1990 • 373 citations

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1985 • 218 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF.

1990 • 196 citations

Protein kinase C and T cell activation

1990 • 183 citations

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

1986 • 178 citations

Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin.

1989 • 143 citations

Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.

1986 • 137 citations

The mitogenic signaling pathway but not the plasminogen activator-inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells.

1989 • 133 citations

1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.

1987 • 124 citations

Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.

1986 • 108 citations

Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue.

1990 • 106 citations

Bovine endothelial cells transformed in vitro by benzo(a)pyrene

1983 • 102 citations

Structural requirements for diacylglycerols to mimic tumor-promoting phobol diester action on the epidermal growth factor receptor.

1985 • 98 citations

Involvement of three intracellular messenger systems, protein kinase C, calcium ion and cyclic AMP, in the regulation of c‐fos gene expression in Swiss 3T3 cells

1986 • 90 citations

Differences in the effects of phorbol esters and diacylglycerols on protein kinase C

1989 • 87 citations

Similar action of platelet‐derived growth factor and epidermal growth factor in the prereplicative phase of human fibroblasts suggests a common intracellular pathway

1985 • 79 citations

Basic fibroblast growth factor: Production, mitogenic response, and post-receptor signal transduction in cultured normal and transformed fetal bovine aortic endothelial cells

1989 • 55 citations

Physiologic 1,2-diacylglycerol levels induce protein kinase C-independent translocation of a regulatory enzyme.

1990 • 53 citations

Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca²⁺ mobilization or inositol phosphate accumulation

1990 • 48 citations

Transmembrane signalling at the epidermal growth factor receptor

1989 • 46 citations

Diacylglycerols, unlike phorbol esters, do not induce homologous desensitization or down-regulation of protein kinase C in Swiss 3T3 cells

1989 • 35 citations

Calcium-activated, phospholipid-dependent protein kinase in pancreatic acinar cells

1985 • 34 citations

Inhibitors of protein kinase C block activation of B lymphocytes by bacterial lipopolysaccharide

1987 • 27 citations

Early and late mitogenic events induced by FGF on Bovine Epithelial Lens cells are not triggered by hydrolysis of polyphosphoinositides

1987 • 26 citations

Fibroblast growth factor‐dependent mitogenic signal transduction pathway in chemically transformed mouse fibroblasts is similar to but distinct from that initiated by phorbol esters

1990 • 25 citations

Induction of plasminogen activator activity by phorbol ester in transformed fetal bovine aortic endothelial cells. Possible independence from protein kinase C

1989 • 11 citations