Protein kinase C: is its pivotal role in cellular activation over-stated?

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1983 • 265 citations

Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin.

1993 • 252 citations

Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.

1993 • 251 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation

1993 • 202 citations

Thrombin-stimulated elevation of human endothelial-cell cytoplasmic free calcium concentration causes prostacyclin production

1988 • 190 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Activation of the PKC‐isotypes α, β₁, γ, δ, and ε by phorbol esters of different biological activities

1991 • 178 citations

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.

1993 • 162 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction

1993 • 157 citations

Therapeutic potential of protein kinase C inhibitors

1993 • 144 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

1993 • 128 citations

Protein kinase C activation by phorbol esters: do cysteine-rich regions and pseudosubstrate motifs play a role?

1991 • 124 citations

Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo

1992 • 121 citations

1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase.

1988 • 120 citations

Protein kinase C activation alters the sensitivity of agonist-stimulated endothelial-cell prostacyclin production to intracellular Ca2+

1989 • 83 citations

Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells.

1993 • 79 citations

Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.

1992 • 72 citations

K252a is a potent and selective inhibitor of phosphorylase kinase

1990 • 63 citations

Inhibition of expression of protein kinase C alpha by antisense cDNA inhibits phorbol ester-mediated arachidonate release

1993 • 59 citations

Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets

1985 • 57 citations

Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing

1993 • 50 citations

Role of Protein Kinase C in the Regulation of Prostaglandin Synthesis in Human Endothelium

1992 • 43 citations

Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells.

1991 • 39 citations

Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases

1991 • 36 citations

Inducible overexpression of human protein kinase C α in NIH 3T3 fibroblasts results in growth abnormalities

1992 • 31 citations

Involvement of calcium in modulation of neutrophil function by phorbol esters that activate protein kinase C isotypes and related enzymes

1993 • 29 citations

Antisense DNA Downregulates Protein Kinase C Isozymes (β and α) and Insulin-Stimulated 2-Deoxyglucose Uptake in Rat Adipocytes

1991 • 21 citations

Phorbol esters induce a slow, non-cytotoxic release of histamine from rat peritoneal mast cells

1987 • 11 citations

A new type of photosynthetic reaction centre

1985 • 11 citations