Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

1973 • 2,213 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Cyclins and cancer

1991 • 701 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

1990 • 422 citations

MAP kinase by any other name smells just as sweet

1992 • 341 citations

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

1990 • 262 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.

1989 • 156 citations

Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

1992 • 134 citations

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC

1991 • 134 citations

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

1992 • 131 citations

Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

1991 • 129 citations

Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a.

1991 • 121 citations

Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle.

1991 • 119 citations

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1993 • 119 citations

Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes.

1992 • 115 citations

The cell cycle then and now

1992 • 69 citations

Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells

1991 • 59 citations

Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C.

1990 • 45 citations

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.

1992 • 41 citations

Cell cycle specific inhibitors

1989 • 30 citations

Synergistic antitumor effect of UCN-01, a protein kinase (C) inhibitor, combined with various anti-cancer agents

1993 • 10 citations