A phase I study of intravenous bryostatin 1 in patients with advanced cancer

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Isolation and structure of bryostatin 1

1982 • 638 citations

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1987 • 228 citations

The measurement of opsonic and phagocytic function by Luminol-dependent chemiluminescence.

1980 • 209 citations

Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor

1985 • 167 citations

Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.

1988 • 166 citations

Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity.

1992 • 133 citations

Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells

1988 • 119 citations

Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.

1987 • 104 citations

Successful treatment of murine melanoma with bryostatin 1.

1991 • 94 citations

Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.

1987 • 80 citations

Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins.

1988 • 76 citations

Varied differentiation responses of human leukemias to bryostatin 1.

1989 • 70 citations

Activation of human T lymphocytes by bryostatin.

1988 • 70 citations

Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells

1989 • 58 citations

Differentiation of HL‐60 cells is associated with an increase in the 35‐kDa protein lipocortin I

1988 • 54 citations

Comparative effects of polymyxin B, phorbol ester and bryostatin on protein phosphorylation, protein kinase C translocation, phospholipid metabolism and differentiation of HL60 cells

1987 • 49 citations

Lack of correlation between peripheral blood lymphokine-activated killer (lak) cell function and clinical response in patients with advanced malignant melanoma receiving recombinant interleukin 2

1989 • 47 citations

Activators of protein kinase C induce myotonia by lowering chloride conductance in muscle

1987 • 46 citations

Effects of bryostatins and retinoic acid on phorbol ester- and diacylglycerol-induced squamous differentiation in human tracheobronchial epithelial cells.

1989 • 46 citations

The action of bryostatin on normal human hematopoietic progenitors is mediated by accessory cell release of growth factors

1990 • 40 citations

Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.

1987 • 40 citations

Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia.

1991 • 30 citations

Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin.

1990 • 26 citations

Effect of pharmacologic manipulation of protein kinase C by phorbol dibutyrate and bryostatin 1 on the clonogenic response of human granulocyte‐macrophage progenitors to recombinant GM‐CSF

1991 • 23 citations

Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation

1990 • 23 citations

Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high-phorbol ester concentrations.

1988 • 23 citations

Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells.

1990 • 22 citations

Conversion of high grade lymphoma tumor cell line to intermediate grade with tpa and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis

1990 • 17 citations

Bryostatins mimic the effects of phorbol esters in intact human platelets

1987 • 16 citations

Regulation of hematopoiesis-IV: The role of interleukin-3 and bryostatin 1 in the growth of erythropoietic progenitors from normal and anemic W/Wv mice

1988 • 16 citations

Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers

1990 • 9 citations

The Effect of Bryostatin 1 on Human Lymphocyte-Mediated Cytotoxicity

1991 • 8 citations

In vitro beta2-microglobulin (β2m) secretion by normal and leukaemic B-cells: effects of recombinant cytokines and evidence for a differential response to the combined stimulus of phorbol ester and calcium ionophore

1990 • 8 citations

The in vitro effect of the antineoplastic agent bryostatin 4 on human hematopoietic progenitor cells.

1988 • 5 citations

Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells

1989 • 4 citations