Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum(II).

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Overexpression of Metallothionein Confers Resistance to Anticancer Drugs

1988 • 600 citations

The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes

1987 • 533 citations

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1

1980 • 477 citations

Tumor Promoters and the Mechanism of Tumor Promotion

1980 • 415 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

Short-termcis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells

1990 • 357 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

1988 • 190 citations

Purification and characterization of three types of protein kinase C from rabbit brain cytosol.

1987 • 168 citations

Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids.

1983 • 157 citations

Enhancement of the antiproliferative effect of cis‐diamminedichloroplatinum(II) and nitrogen mustard by inhibitors of protein kinase C

1988 • 120 citations

Possible mechanism of phorbol diester-induced maturation of human promyelocytic leukemia cells.

1984 • 110 citations

Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein.

1988 • 105 citations

Differential uptake of cis-diamminedichloroplatinum (II) by sensitive and resistant murine L1210 leukemia cells.

1987 • 102 citations

Properties of amino acid transport systems in K562 cells sensitive and resistant to cis-diamminedichloroplatinum(II).

1986 • 88 citations

Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine.

1981 • 82 citations

Activation of distinct protein kinase C isozymes by phorbol esters: correlation with induction of interleukin 1.beta. gene expression

1989 • 73 citations

Inhibition of MCF-7 cell growth by 12-O-tetradecanoylphorbol-13-acetate and 1,2-dioctanoyl-sn-glycerol: distinct effects on protein kinase C activity.

1988 • 71 citations

Carrier-dependent and carrier-independent transport of anti-cancer alkylating agents

1981 • 68 citations

Phorbol Diesters and Cellular Differentiation<xref ref-type="fn" rid="FN5">5</xref>

1984 • 67 citations

Characterization of the association of radiolabeled bleomycin A2 with HeLa cells.

1984 • 66 citations

Mechanism of protein kinase C inhibition by sphingosine

1987 • 65 citations

Transient protection of cultured human cells against antitumor agents by 12-O-tetradecanoylphorbol-13-acetate.

1987 • 64 citations

High-performance liquid chromatographic determination of platinum (II) in plasma ultrafiltrate and urine: comparison with a flameless atomic absorption spectrometric method

1984 • 57 citations

The adriamycin-iron(III) complex is a potent inhibitor of protein kinase C

1989 • 56 citations

Synergistic enhancement of the antiproliferative activity ofcis‐diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C

1989 • 47 citations

Early effects of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate on the cell cycle traverse of asynchronous HeLa cells.

1981 • 35 citations

Intracellular distribution of a platinum-rhodamine 123 complex in cis-platinum sensitive and resistant human squamous carcinoma cell lines

1986 • 33 citations

Possible mechanism for differences in sensitivity to cis-platinum in human prostate tumor cell lines

1986 • 31 citations

In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells.

1988 • 29 citations

Phorbol Ester-mediated Down-regulation of an Interferon-inducible Gene

1989 • 26 citations

Phorbol ester restores L-system amino acid transport of B lymphocytes in chronic lymphocytic leukemia.

1988 • 13 citations

TPA enhancement of the recovery of methotrexate and N‐phosphonacetyl L‐aspartate resistant mouse 3T6 cell clones is associated with transient alterations of cell cycle progression

1988 • 5 citations