Cellular Biology of Cartilage Degradation

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

ARTHRITIS AND ALLIED CONDITIONS

1949 • 1,599 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes

1988 • 929 citations

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips

1970 • 826 citations

Arthritis and Allied Conditions: A Textbook of Rheumatology.

1991 • 775 citations

Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content.

1982 • 750 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

1992 • 620 citations

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.

1994 • 611 citations

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.

1989 • 604 citations

Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition.

1977 • 583 citations

Intraneuronal Substance P Contributes to the Severity of Experimental Arthritis

1984 • 521 citations

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

1992 • 502 citations

Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.

1986 • 496 citations

Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus

1986 • 492 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues.

1985 • 451 citations

Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis

1987 • 450 citations

The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans

1973 • 448 citations

Type x collagen synthesis in human osteoarthritic cartilage. indication of chondrocyte hypertrophy

1992 • 445 citations

Mechanical and physicochemical determinants of the chondrocyte biosynthetic response

1988 • 434 citations

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

1990 • 428 citations

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

1992 • 412 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.

1988 • 391 citations

Effect of oxygen‐derived free radicals on hyaluronic acid

1980 • 368 citations

Disorders of bone and mineral metabolism

1993 • 353 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

Age-related changes in the structure of the proteoglycan subunits from human articular cartilage.

1980 • 338 citations

The Effect of Proteoglycans on the Morphology of Collagen Fibrils Formed In Vitro

1987 • 329 citations

Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis

1993 • 325 citations

An Ultrastructural Study of Normal Young Adult Human Articular Cartilage

1968 • 324 citations

Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium.

1992 • 314 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Quantification of keratan sulfate in blood as a marker of cartilage catabolism

1985 • 310 citations

Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants

1988 • 310 citations

The intrinsic tensile behavior of the matrix of bovine articular cartilage and its variation with age.

1980 • 307 citations

Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage

1986 • 305 citations

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

1989 • 298 citations

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

1992 • 297 citations

Growth Factors Regulate Transin Gene Expression by c- fos -Dependent and c- fos -Independent Pathways

1988 • 290 citations

Induction of Nitric Oxide Synthase in Human Chondrocytes

1993 • 286 citations

Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint

1984 • 286 citations

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1991 • 285 citations

Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines

1989 • 280 citations

Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia.

1990 • 280 citations

Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

1991 • 278 citations

Transforming growth factor beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures.

1988 • 274 citations

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.

1992 • 273 citations

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells.

1986 • 271 citations

Effects of static and cyclic compressive loading on articular cartilage plugs in vitro

1984 • 265 citations

Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids

1991 • 262 citations

Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

1984 • 262 citations

Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors.

1988 • 261 citations

Detection of Stromelysin and Collagenase in Synovial Fluid From Patients with Rheumatoid Arthritis and Posttraumatic Knee Injury

1992 • 261 citations

Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.

1991 • 260 citations

Cartilage Molecular Aspects

1991 • 258 citations

Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease.

1992 • 250 citations

Modulation by interleukin 1 and tumor necrosis factor α of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes

1990 • 247 citations

Hyaluronic acid in human articular cartilage. Age-related changes in content and size

1988 • 243 citations

Collagen synthesis in normal and osteoarthritic human cartilage.

1977 • 242 citations

Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo.

1989 • 241 citations

Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage.

1993 • 236 citations

Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase

1989 • 233 citations

Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.

1990 • 229 citations

Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules

1985 • 227 citations

Synovial fluid concentration of five different cytokines in rheumatic diseases.

1990 • 226 citations

Augmented interleukin‐1 production and hla–dr expression in the synovium of rheumatoid arthritis patients

1988 • 222 citations

Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis

1980 • 218 citations

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

1977 • 218 citations

Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium

1991 • 217 citations

Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.

1987 • 217 citations

Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture.

1992 • 208 citations

In Situ Hybridization Studies of Stromelysin and Collagenase Messenger RNA Expression in Rheumatoid Synovium

1991 • 206 citations

Relationship between the tensile properties of articular cartilage from the human knee and age.

1982 • 206 citations

The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.

1990 • 202 citations

Increased levels of proteoglycan fragments in knee joint fluid after injury

1989 • 198 citations

Effects of mechanical and osmotic pressure on the rate of glycosaminoglycan synthesis in the human adult femoral head cartilage: An in vitro study

1986 • 197 citations

The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis

1990 • 197 citations

Age-related changes in the tensile properties of human articular cartilage: a comparative study between the femoral head of the hip joint and the talus of the ankle joint

1991 • 197 citations

Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation.

1990 • 196 citations

Transport of solutes through cartilage: permeability to large molecules.

1976 • 192 citations

The degradation of articular collagen by neutrophil proteinases

1977 • 189 citations

Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion.

1993 • 188 citations

Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines.

1990 • 187 citations

The interleukin‐1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function

1992 • 186 citations

DELETERIOUS EFFECT OF INTRA-ARTICULAR HYDROCORTISONE

1958 • 184 citations

Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes.

1992 • 183 citations

Mechanism of catabolism of aggrecan by articular cartilage

1992 • 182 citations

The role of superoxide and hydroxyl radicals in the degradation of hyaluronic acid induced by metal ions and by ascorbic acid

1981 • 180 citations

Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants

1991 • 178 citations

The Acute Effects of Intra-Articular Hydrocortisone on Articular Cartilage in Rabbits

1966 • 172 citations

Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis.

1994 • 171 citations

Collagenase and collagenolytic activity in human osteoarthritic cartilage

1983 • 168 citations

Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

1991 • 164 citations

Substrate specificities and activation mechanisms of matrix metalloproteinases

1991 • 164 citations

The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis

1993 • 163 citations

Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes

1986 • 161 citations

Electron microscopic studies of the cartilage‐pannus junction in rheumatoid arthritis

1975 • 157 citations

lnterleukin-1 Stimulates andAll-Trans-Retinoic Acid Inhibits Collagenase Gene Expression through Its 5′ Activator Protein-1-Binding Site

1990 • 154 citations

Joint cartilage degradation : basic and clinical aspects

1993 • 152 citations

Tumor promoter-stimulated Mr 92,000 gelatinase secreted by normal and malignant human cells: isolation and characterization of the enzyme from HT1080 tumor cells.

1990 • 151 citations

Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes.

1986 • 151 citations

Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator

1992 • 151 citations

Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro

1985 • 150 citations

Cartilage proteoglycans. Assembly with hyaluronate and link protein as studied by electron microscopy

1988 • 148 citations

Inhibition of cartilage proteoglycan synthesis by interleukin 1

1988 • 146 citations

Osteoarthritis and articular chondrocalcinosis in the elderly.

1983 • 146 citations

Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts.

1987 • 146 citations

Insulin‐like growth factor stimulation of chondrocyte proteoglycan synthesis by human synovial fluid

1989 • 145 citations

Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1.

1993 • 145 citations

Physiological mechanisms for metalloproteinase activation.

1992 • 142 citations

Extended and globular protein domains in cartilage proteoglycans

1987 • 140 citations

Increased concentrations of proteoglycan components in the synovial fluids of patients with acute but not chronic joint disease.

1988 • 139 citations

Biochemical changes in progressive osteoarthrosis.

1977 • 138 citations

Effects of murine recombinant interleukin 1 on synovial joints in mice: measurement of patellar cartilage metabolism and joint inflammation.

1990 • 138 citations

Levels of circulating tumor necrosis factor α and interleukin‐6 in patients with rheumatoid arthritis. relationship to serum levels of hyaluronan and antigenic keratan sulfate

1993 • 135 citations

Transforming growth factor-β is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation

1988 • 134 citations

Localization of a dermatan sulfate proteoglycan (DS-PGII) in cartilage and the presence of an immunologically related species in other tissues.

1986 • 131 citations

N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

1992 • 131 citations

Soluble tumor necrosis factor receptors in human inflammatory synovial fluids

1993 • 129 citations

Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity.

1993 • 128 citations

Immunolocalization of metalloproteinases and their inhibitor in the rabbit growth plate.

1989 • 125 citations

Independent effects of interleukin‐1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E₂ release from cartilage in organ culture

1989 • 125 citations

Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte‐mediated proteoglycan degradation

1993 • 123 citations

Biosynthesis, secretion and extracellular localization of anchorin CII, a collagen-binding protein of the calpactin family.

1988 • 122 citations

Cartilage response to mechanical force in high‐density chondrocyte cultures

1985 • 121 citations

Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.

1990 • 119 citations

The extracellular matrix of cartilage in the growth plate before and during calcification: Changes in composition and degradation of type II collagen

1992 • 118 citations

Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ

1989 • 117 citations

Metabolic activity of articular cartilage in osteoarthritis. An in vitro study.

1979 • 116 citations

Expression of type‐X collagen in osteoarthritis

1995 • 115 citations

Expression of IL-1 genes in human and bovine chondrocytes: A mechanism for autocrine control of cartilage matrix degradation

1986 • 113 citations

Transforming growth factor β exerts opposite effects from interleukin‐1β on cultured rabbit articular chondrocytes through reduction of interleukin‐1 receptor expression

1993 • 111 citations

Immunoelectron microscopic studies of type X collagen in endochondral ossification.

1989 • 111 citations

The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis

1987 • 110 citations

Transcriptional regulation of human stromelysin

1989 • 109 citations

Collagenase and collagenase inhibitors in osteoarthritic and normal cartilage.

1977 • 109 citations

Gene expression in mineralizing chick epiphyseal cartilage.

1988 • 109 citations

Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein

1993 • 104 citations

Matrix vesicles are enriched in metalloproteinases that degrade proteoglycans

1992 • 102 citations

Effect of Interleukin-1 and Insulin Like Growth Factor-1 on the Release of Proteoglycan Components and Hyaluronan from Pig Articular Cartilage in Explant Culture

1991 • 102 citations

Direct Evidence for Active Metalloproteinases Mediating Matrix Degradation in Interleukin 1-Stimulated Human Articular Cartilage

1993 • 98 citations

INCREASED SERUM CONCENTRATIONS OF CARTILAGE OLIGOMERIC MATRIX PROTEIN. A PROGNOSTIC MARKER IN EARLY RHEUMATOID ARTHRITIS

1992 • 98 citations

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

1989 • 98 citations

Increases in levels of procollagenase messenger RNA in cultured fibroblasts induced by human recombinant interleukin 1 beta or serum follow c-jun expression and are dependent on new protein synthesis.

1989 • 97 citations

The distribution of aggregating proteoglycans in articular cartilage: comparison of quantitative immunoelectron microscopy with radioimmunoassay and biochemical analysis.

1984 • 97 citations

Variations in the composition of bovine hip articular cartilage with distance from the articular surface

1981 • 96 citations

Identification of a hyaluronic acid-binding protein that interferes with the preparation of high-buoyant-density proteoglycan aggregates from adult human articular cartilage

1985 • 94 citations

Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.

1990 • 94 citations

Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin 1 antibodies in experimental arthritis.

1992 • 94 citations

Osteoarthritis in the Human Knee: A Dynamic Process of Cartilage Matrix Degradation, Synthesis and Reorganization

1993 • 93 citations

Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the Blood Markers Hyaluronic Acid, Orosomucoid, and Keratan Sulfate

1990 • 92 citations

Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage.

1992 • 92 citations

Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form

1991 • 92 citations

Proteoglycan fragments in joint fluid

1992 • 90 citations

Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage.

1992 • 90 citations

Comparative analysis of collagens solubilized from human foetal, and normal and osteoarthritic adult articular cartilage, with emphasis on type VI collagen

1990 • 90 citations

Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture.

1975 • 89 citations

In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1.

1991 • 89 citations

Studies on cathepsin B in human articular cartilage

1978 • 85 citations

Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions

1992 • 82 citations

Localization of collagenase in the growth plate of rachitic rats.

1985 • 81 citations

Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator

1988 • 81 citations

Degradation of human proteoglycan aggregate induced by hydrogen peroxide. Protein fragmentation, amino acid modification and hyaluronic acid cleavage

1989 • 81 citations

Serum keratan sulfate levels in osteoarthritis patients

1988 • 79 citations

Stimulation of collagenase production by collagen in mammalian cell cultures

1979 • 78 citations

Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts.

1991 • 76 citations

Substance P levels in the synovium and synovial fluid from patients with rheumatoid arthritis and osteoarthritis.

1993 • 76 citations

In vivo effects of interleukin‐1 on articular cartilage. Prolongation of proteoglycan metabolic disturbances in old mice

1991 • 75 citations

Autopsy study correlating degree of osteoarthritis, synovitis and evidence of articular calcification.

1984 • 75 citations

Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin.

1992 • 75 citations

IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway.

1990 • 70 citations

Biological markers in rheumatoid arthritis

1994 • 70 citations

Cartilage expression of a type II collagen mutation in an inherited form of osteoarthritis associated with a mild chondrodysplasia.

1991 • 70 citations

Ultrastructural changes in articular cartilage after experimental section of the anterior cruciate ligament of the dog knee.

1983 • 70 citations

Markers of cartilage metabolism in arthrosis

1991 • 69 citations

Transforming growth factor-? inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes

1991 • 67 citations

Release of cartilage macromolecules into the synovial fluid in patients with acute and prolonged phases of reactive arthritis

1993 • 66 citations

Recombinant human interleukin‐1 β–induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid

1992 • 66 citations

Cartilage proteoglycan depletion in acute and chronic antigen‐induced arthritis

1989 • 66 citations

Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.

1990 • 66 citations

The structure of anchorin CII, a collagen binding protein isolated from chondrocyte membrane.

1988 • 66 citations

Local changes in proteoglycan synthesis during culture are different for normal and osteoarthritic cartilage.

1992 • 65 citations

Link protein as a monitor in situ of endogenous proteolysis in adult human articular cartilage

1991 • 65 citations

Growth promoting peptides in osteoarthritis: insulin, insulin-like growth factor-1, growth hormone.

1991 • 64 citations

Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains

1991 • 63 citations

Intracellular collagen fibers at the pannus‐cartilage junction in rheumatoid arthritis

1977 • 63 citations

Effect of purified growth factors on rabbit articular chondrocytes in monolayer culture. II. sulfated proteoglycan synthesis

1982 • 62 citations

Hyaluronate in articular cartilage: Age-related changes

1978 • 62 citations

CHONDROCYTE NONRESPONSIVENESS TO INSULIN‐LIKE GROWTH FACTOR 1 IN EXPERIMENTAL ARTHRITIS

1989 • 61 citations

The effect of human interleukin 1 on proteoglycan metabolism in human and porcine cartilage explants.

1990 • 61 citations

Regulation of proteoglycan synthesis rate in cartilage in vitro: influence of extracellular ionic composition

1989 • 61 citations

Synthesis of fibronectin in normal and osteoarthritic articular cartilage

1984 • 59 citations

The Immunoperoxidase Localization of Type X Collagen in Chick Cartilage and Lung

1986 • 58 citations

Synthesis of Type II Collagen is Decreased in Cartilage Cultured with Interleukin 1 while the Rate of Intracellular Degradation Remains Unchanged

1988 • 58 citations

Application of monoclonal antibodies to the characterization of cells eluted from human articular cartilage. Expression of Ia Antigens in Certain Diseases and Identification of an 85‐kD Cell Surface Molecule Accumulated in the Pericellular Matrix

1983 • 57 citations

Structure of cDNAs Encoding the Triple-Helical Domain of Murine α2 (VI) Collagen Chain and Comparison to Human and Chick Homologues. Use of Polymerase Chain Reaction and Partially Degenerate Oligonucleotides for Generation of Novel cDNA Clones

1991 • 56 citations

Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases

1992 • 54 citations

Immunochemical markers of joint inflammation, skeletal damage and repair: where are we now?

1994 • 54 citations

The Degradation of Type II Collagen in Rheumatoid Arthritis: An Immunoelectron Microscopic Study

1991 • 54 citations

The extracellular processing and catabolism of hyaluronan in cultured adult articular cartilage explants

1992 • 54 citations

Induction of synthesis and release of interleukin‐8 from human articular chondrocytes and cartilage explants

1992 • 54 citations

Rabbit procollagenase synthesized and secreted by a high-yield mammalian expression vector requires stromelysin (matrix metalloproteinase-3) for maximal activation.

1990 • 52 citations

Experimental osteoarthritic articular cartilage is enriched in guanidine-soluble type VI collagen

1988 • 51 citations

A mechanism for cartilage destruction in rheumatoid arthritis.

1970 • 50 citations

In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin‐1β

1992 • 49 citations

Surface Ultrastructure of Rheumatoid Articular Cartilage

1977 • 49 citations

The action of human articular-cartilage metalloproteinase on proteoglycan and link protein. Similarities between products of degradation in situ and in vitro

1986 • 47 citations

Cathepsin B and cysteine protease inhibitors in human osteoarthritis

1990 • 47 citations

The effects of leucocyte elastase on the mechanical properties of adult human articular cartilage in tension

1981 • 46 citations

Expression of Intercellular Adhesion Molecule 1 (Icam-1) on Human Articular Cartilage Chondrocytes

1991 • 46 citations

Changes in Proteoglycan and Collagen in Cartilage in Rheumatoid Arthritis

1978 • 46 citations

Effects of IGF-I, EGF, and FGF on proteoglycans synthesized by fractionated chondrocytes of rat rib growth plate*1

1988 • 46 citations

Effects of human recombinant tumor necrosis factor-alpha and interleukin 1 on the synthesis of glycosaminoglycan and DNA in cultured rat costal chondrocytes.

1988 • 45 citations

Hyaluronan-binding region of aggrecan from pig laryngeal cartilage. Amino acid sequence, analysis of N-linked oligosaccharides and location of the keratan sulphate

1992 • 44 citations

Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity

1992 • 43 citations

Intra-Articular Administration of Interleukin-1 Causes Prolonged Suppression of Cartilage Proteoglycan Synthesis in Rats

1992 • 42 citations

Plasminogen activators in synovial fluid and plasma from patients with arthritis.

1992 • 42 citations

Inhibition of proteoglycan synthesis by transforming growth factor beta in anatomically intact articular cartilage of murine patellae.

1992 • 41 citations

Human cartilage is degraded by rheumatoid arthritis synovial fluid but not by recombinant cytokines in vitro

1991 • 41 citations

Identification of Fibronectin in Preparations of Osteoarthritic Human Cartilage

1984 • 40 citations

Tumor necrosis factor α and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes

1991 • 40 citations

Fibroblast growth factor enhances the interleukin-1-mediated chondrocytic protease release

1987 • 39 citations

Bidirectional erosion of cartilage in the rheumatoid knee joint.

1985 • 39 citations

The role of plasminogen in interleukin-1 mediated cartilage degradation.

1988 • 39 citations

Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation

1992 • 39 citations

Treatment of cartilage proteoglycan aggregate with hydrogen peroxide. Relationship between observed degradation products and those that occur naturally during aging

1987 • 39 citations

Metalloproteinase digestion of cartilage proteoglycan. Pattern of cleavage by stromelysin and susceptibility to collagenase

1991 • 37 citations

Activation of TIMP-2/progelatinase a complex by stromelysin

1992 • 36 citations

Collagens Act as Ligands to Stimulate Human Monocytes to Produce Mononuclear Cell Factor (MCF) and Prostaglandins (PGE2)

1982 • 35 citations

Keratan sulphate in rheumatoid arthritis, osteoarthritis, and inflammatory diseases.

1992 • 34 citations

SUSCEPTIBILITY OF NORMAL AND ARTHRITIC HUMAN ARTICULAR CARTILAGE TO DEGRADATIVE STIMULI

1992 • 34 citations

Platelet‐derived growth factor potentiates cellular responses of articular chondrocytes to interleukin‐1

1991 • 34 citations

Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391.

1993 • 33 citations

Isolation and characterization of a metalloprotease associated with chicken epiphyseal cartilage matrix vesicles

1986 • 33 citations

Inhibition of interleukin‐1‐induced collagenase production in human articular chondrocytes in vitro by recombinant human interferon‐gamma

1990 • 33 citations

The synovial activation of chondrocytes: evidence for complex cytokine interactions involving a possible novel factor

1992 • 32 citations

Recombinant human inteleukin-1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes

1991 • 32 citations

Modulation of interleukin‐1–induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C

1991 • 31 citations

Early‐onset primary osteoarthritis and mild chondrodysplasia

1990 • 30 citations

Differential modulation of degradative and repair responses of interleukin-1-treated chondrocytes by platelet-derived growth factor

1993 • 27 citations

Interactions between interleukin‐1 and basic fibroblast growth factor on articular chondrocytes. Effects on cell growth, prostanoid production, and receptor modulation

1991 • 27 citations

Effect of interleukin‐1β on the production of cathepsin B by rabbit articular chondrocytes

1990 • 27 citations

The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages

1987 • 26 citations

Stimulation of interleukin‐1α and interleukin‐1β release from human monocytes by cyanogen bromide peptides of type ii collagen

1988 • 25 citations

Production of Collagenase and Tissue Inhibitor of Metal loproteinases (TIMP) by Rat Growth Plates in Culture

1990 • 23 citations

Cytokine enhancement of monocyte/synovial cell attachment to the surface of cartilage: a possible trigger of pannus formation in arthritis

1991 • 21 citations

Increased interleukin 1β production of macrophages by proteoglycan fragments deriving from articular cartilagein vitro

1990 • 21 citations

Inflammatory cell changes in haversian canals. A possible cause of osteoporosis in rheumatoid arthritis

1989 • 20 citations

Inflammatory Cytokines and Enzymes in Synovial Fluid of Patients with Rheumatoid Arthritis and Other Arthritides

1992 • 19 citations

The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes

1993 • 18 citations

Synergistic Regulation of Collagen Gene Expression in Human Chondrocytes by Tumor Necrosis Factor‐α and Interleukin‐1β^a

1990 • 18 citations

Collagens stimulate the production of mononuclear cell factor (MCF) and prostaglandins (PGE2) by human monocytes.

1980 • 18 citations

Ultrastructure of synovio-cartilage junction in rheumatoid arthritis.

1973 • 18 citations

ICAM‐1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines

1992 • 17 citations

Co‐operation between interleukin‐1 and the fibrinolytic system in the degradation of collagen by articular chondrocytes

1990 • 17 citations

<b>PROTEINASES AND THEIR INHIBITORS IN NORMAL AND OSTEOARTHRITIC ARTICULAR </b><b>CARTILAGE </b>

1987 • 16 citations

Experimental Arthritis Models in the Study of the Mechanisms of Articular Cartilage Loss in Rheumatoid Arthritis

1993 • 15 citations

Rheumatoid Arthritis: Pathogenetic Mechanisms and Consequences in Therapeutics

1972 • 15 citations

The human collagen X gene: complete primary sequence and re-expression in osteoarthritis

1991 • 15 citations

Synovial fluid concentrations of interleukin-1β and proteoglycans are inversely related

1988 • 14 citations

The Type of Collagen made by the Articular Cartilage in Joints of Dogs with Degenerative Joint Disease

1982 • 12 citations

Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.

1990 • 12 citations

Influence of continuous infusion of interleukin‐1α on the core protein and the core protein fragments of the small proteoglycan decorin in cartilage

1992 • 11 citations

Characterization of Murine Lymphokine-Activated Killer Cell Cultures Separated According to Cell Size

1993 • 7 citations

<b>PARTIAL PURIFICATION AND CHARACTERIZATION OF PROTEODERMATAN SULPHATE-DEGRADING PROTEINASES PRODUCED BY HUMAN GINGIVAL </b><b>FIBROBLASTS </b>

1988 • 5 citations