Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

1982 • 2,259 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

1985 • 659 citations

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

1986 • 429 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.

1988 • 391 citations

A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen

1979 • 350 citations

Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts.

1985 • 335 citations

Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride

1987 • 262 citations

Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.

1987 • 255 citations

Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts.

1984 • 228 citations

[52] Mammalian collagenases

1981 • 219 citations

Synthesis and extracellular deposition of fibronectin in chondrocyte cultures. Response to the removal of extracellular cartilage matrix.

1978 • 219 citations

Detergent-activation of latent collagenase and resolution of its component molecules

1982 • 202 citations

Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.

1987 • 195 citations

Fibronectin alters the phenotypic properties of cultured chick embryo chondroblasts

1979 • 177 citations

Mononuclear Cell-Conditioned Medium Containing Mononuclear Cell Factor (MCF), Homologous With Interleukin 1, Stimulates Collagen and Fibronectin Synthesis by Adherent Rheumatoid Synovial Cells: Effects of Prostaglandin E2 and Indomethacin

1985 • 165 citations

The mechanism of precartilage mesenchymal condensation: A major role for interaction of the cell surface with the amino-terminal heparin-binding domain of fibronectin

1989 • 150 citations

Synthesis and localization of fibronectin during collagenous matrix-mesenchymal cell interaction and differentiation of cartilage and bone in vivo.

1980 • 150 citations

Insulin‐like growth factor stimulation of chondrocyte proteoglycan synthesis by human synovial fluid

1989 • 145 citations

Independent effects of interleukin‐1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E₂ release from cartilage in organ culture

1989 • 125 citations

Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth.

1985 • 118 citations

Significance of fibronectin in rheumatoid arthritis and osteoarthrosis.

1981 • 114 citations

Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser.

1985 • 111 citations

Chondrocyte-matrix interactions

1989 • 110 citations

PGE2 causes a coordinate decrease in the steady state levels of fibronectin and types I and III procollagen mRNAs in normal human dermal fibroblasts

1987 • 100 citations

Localization of cell surface sites involved in fibronectin fibrillogenesis.

1987 • 95 citations

The effect of bacterial lipopolysaccharides on the biosynthesis and release of proteoglycans from calf articular cartilage cultures.

1984 • 85 citations

Fibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulation.

1988 • 79 citations

Latex beads as probes of cell surface-extracellular matrix interactions during chondrogenesis: Evidence for a role for amino-terminal heparin-binding domain of fibronectin

1989 • 77 citations

Fibrin and fibronectin in rheumatoid synovial membrane and rheumatoid synovial fluid

1983 • 75 citations

Model of fibronectin tertiary structure based on studies of interactions between fragments

1986 • 72 citations

Detection and quantitation of fibronectin in synovial fluid from patients with rheumatic disease.

1981 • 69 citations

Transforming growth factor-beta increases transcription of the genes encoding the epidermal growth factor receptor and fibronectin in normal rat kidney fibroblasts.

1988 • 65 citations

Synthesis of fibronectin in normal and osteoarthritic articular cartilage

1984 • 59 citations

Interleukin 2‐independent stimulation of rabbit chondrocyte collagenase and prostaglandin E₂ production by an interleukin 1‐like factor

1984 • 58 citations

Some recombinant human cytokines stimulate glycosaminoglycan synthesis in human synovial fibroblast cultures and inhibit it in human articular cartilage cultures

1989 • 56 citations

An immunohistochemical study of fibronectin in human osteoarthritic and disease free articular cartilage.

1987 • 56 citations

The synthesis and accumulation of fibronectin by human articular cartilage.

1990 • 55 citations

Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth: structure-function correlations

1986 • 53 citations

Characterization of synovial fluid fibronectin from patients with rheumatic inflammatory diseases and healthy subjects

1984 • 50 citations

Deposition of fibronectin in articular cartilage of canine osteoarthritic joints.

1985 • 44 citations

Presence of fibronectin in articular cartilage in two animal models of osteoarthritis.

1986 • 41 citations

Identification of Fibronectin in Preparations of Osteoarthritic Human Cartilage

1984 • 40 citations

A semicontinuous, high-performance liquid chromatography-based assay for stromelysin

1989 • 37 citations

Stimulation of Rat Macrophage Interleukin 1 Secretion by Plasma Fibronectin

1987 • 33 citations

Immunoelectron microscopic demonstration of fibronectin in rheumatoid pannus and at the cartilage-pannus junction.

1983 • 32 citations

Synovial Fluid and Plasma Fibronectin Levels in Rheumatoid Arthritis

1982 • 32 citations

The amino-terminal 29- and 72-Kd fragments of fibronectin mediate selective monocyte recruitment

1990 • 31 citations

Ultrastructural localisation of fibronectin in human osteoarthritic articular cartilage.

1987 • 30 citations

Synthesis, secretion, and deposition of fibronectin in cultured human synovium

1985 • 26 citations

Modulation of chondrogenic expression in cell culture by fibronectin

1981 • 22 citations

Interaction of culture-derived macrophages with the fibroblast-binding domain of fibronectin is a necessary but inefficient signal for fibronectin enhancement of CR1-mediated phagocytosis.

1986 • 21 citations

A specificity for cellular fibronectin in its effect on cultured chondroblasts

1984 • 20 citations

Biology of Extracellular Matrix: A Series

1989 • 7 citations

Synthetic peptides of the amino-terminus of fibronectin inhibit endothelial cell growth

1989 • 5 citations