Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte‐mediated proteoglycan degradation

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

1986 • 3,282 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

1969 • 779 citations

A novel coumarin‐labelled peptide for sensitive continuous assays of the matrix metalloproteinases

1992 • 692 citations

Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.

1986 • 496 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

1992 • 412 citations

Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues

1984 • 387 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

The effect of hypervitaminosis A on embryonic limb‐bones cultivated in vitro

1952 • 316 citations

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

1992 • 297 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1991 • 285 citations

Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro

1991 • 271 citations

Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

1984 • 262 citations

IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA.

1990 • 242 citations

Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo

1991 • 213 citations

CA074 methyl ester: A proinhibitor for intracellular cathepsin B

1992 • 200 citations

Mechanism of catabolism of aggrecan by articular cartilage

1992 • 182 citations

In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.

1986 • 175 citations

COMPARISON OF THE EFFECTS OF PAPAIN AND VITAMIN A ON CARTILAGE

1960 • 158 citations

Physiological mechanisms for metalloproteinase activation.

1992 • 142 citations

The degradation of cartilage matrix by an intracellular protease

1964 • 141 citations

IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.

1989 • 116 citations

Assay of Pyrogens by Interleukin-6 Release from Monocytic Cell Lines

1991 • 99 citations

Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.

1990 • 96 citations

Inhibition of cysteine proteinases in lysosomes and whole cells

1992 • 84 citations

Leucocyte infiltration and cartilage proteoglycan loss in immune arthritis in the rabbit

1988 • 71 citations

Murine interleukin‐1 receptor: Differences in binding properties between fibroblastic and thymoma cells and evidence for a two‐chain receptor model

1987 • 56 citations

Characterization of cathepsins in cartilage

1967 • 56 citations

Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases

1992 • 54 citations

Inhibition by pepstatin of human cartilage degradation

1972 • 52 citations

Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro.

1991 • 51 citations

THE IMMUNOCYTOCHEMICAL DEMONSTRATION OF CATHEPSIN D

1972 • 50 citations

A synthetic peptide metalloproteinase inhibitor, but not Timp, prevents the breakdown of proteoglycan within articular cartilagein vitro

1992 • 43 citations

Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation

1992 • 39 citations

Effect of synthetic metalloprotease inhibitors on cartilage autolysis in vitro.

1987 • 32 citations

FLUSYS: a software package for the collection and analysis of kinetic and scanning data from Perkin-Elmer fluorimeters

1990 • 28 citations