Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Enhanced autoradiographic detection of ³²P and ¹²⁵I using intensifying screens and hypersensitized film

1977 • 947 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

1987 • 524 citations

Cloning and characterization of five overlapping cDNAs specific for the human proα 1(I) collagen chain

1982 • 496 citations

Messenger RNA for myosin polypeptides: Isolation from single myogenic cell cultures

1977 • 417 citations

Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

1983 • 393 citations

Activation of two signal-transduction systems in hepatocytes by glucagon

1986 • 383 citations

The Effect of Synovial Tissue on the Breakdown of Articular Cartilage in Organ Culture

1977 • 312 citations

Identification of three genetically distinct collagens by cyanogen bromide cleavage of insoluble human skin and cartilage collagen

1971 • 292 citations

Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta

1988 • 243 citations

Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis

1980 • 218 citations

Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.

1987 • 195 citations

Mononuclear Cell-Conditioned Medium Containing Mononuclear Cell Factor (MCF), Homologous With Interleukin 1, Stimulates Collagen and Fibronectin Synthesis by Adherent Rheumatoid Synovial Cells: Effects of Prostaglandin E2 and Indomethacin

1985 • 165 citations

Analysis of changes in collagen biosynthesis that occur when chick chondrocytes are grown in 5-bromo-2'-deoxyuridine.

1975 • 161 citations

Electron microscopic studies of the cartilage‐pannus junction in rheumatoid arthritis

1975 • 157 citations

Purification and characterization of human interleukin‐1β expressed in recombinant Escherichia coli

1986 • 153 citations

Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes.

1986 • 151 citations

Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator

1980 • 134 citations

Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the pond‐nuki dog model of osteoarthritis

1983 • 133 citations

In vitro activation of human chondrocytes and synoviocytes by a human interleukin‐1‐like factor

1984 • 125 citations

Human type III collagen gene expression is coordinately modulated with the type I collagen genes during fibroblast growth

1986 • 117 citations

Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts

1987 • 117 citations

The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities.

1985 • 111 citations

Brain peptides and glial growth. I. Glia-promoting factors as regulators of gliogenesis in the developing and injured central nervous system.

1986 • 104 citations

Interleukin‐1β and interleukin‐1α stimulate the plasminogen activator activity and prostaglandin E₂ levels of human synovial cells

1987 • 101 citations

Human Actin Genes Are Single Copy for α-Skeletal and α-Cardiac Actin but Multicopy for β- and γ-Cytoskeletal Genes: 3′ Untranslated Regions Are Isotype Specific but Are Conserved in Evolution

1983 • 94 citations

Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated wth decreaded levels of the procollagen mRNAs(FEBS 2156)

1985 • 83 citations

Specific bioactivities of monocyte-derived interleukin 1 alpha and interleukin 1 beta are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells.

1986 • 82 citations

Synthesis of cartilage matrix by mammalian chondrocytes in vitro. III. Effects of ascorbate.

1984 • 81 citations

Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1β or phorbol ester

1987 • 81 citations

Activation of neutrophils and the lesions of rheumatoid arthritis.

1982 • 54 citations

Control of Types I and II Collagen and Fibronectin Gene Expression in Chondrocytes Delineated by Viral Transformation

1985 • 51 citations

Changes in proteoglycan and collagen in cartilage in rheumatoid arthritis.

1978 • 40 citations

Effects of retinol and dexamethasone on cytokine-mediated control of metalloproteinases and their inhibitors by human articular chondrocytes and synovial cells in culture

1983 • 36 citations

Control of types I and II collagen and fibronectin gene expression in chondrocytes delineated by viral transformation.

1985 • 24 citations

Rheumatoid synovial cell hormone responses modulated by cell-cell interactions

1984 • 23 citations

Effect of retinoids on collagen production by chondrocytes in culture

1984 • 18 citations

Enhanced production of prostaglandins and plasminogen activator during activation of human articular chondrocytes by products of mononuclear cells

1984 • 15 citations

Adenylate cyclase of human articular chondrocytes. Responsiveness to prostaglandins and other hormones

1982 • 13 citations