Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

1986 • 3,282 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

1985 • 738 citations

Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

1984 • 262 citations

The effects of inhibitors of cysteine-proteinases and collagenase on the resorptive activity of isolated osteoclasts☆

1987 • 176 citations

In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.

1986 • 175 citations

Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro

1985 • 150 citations

Inhibition of bone resorption in culture by inhibitors of thiol proteinases

1980 • 120 citations

Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.

1990 • 96 citations

Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro

1983 • 81 citations

Efficient synthetic method for ethyl (+)-(2S,3S)-3-((S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylate (EST), a new inhibitor of cysteine proteinases.

1987 • 62 citations

Murine interleukin‐1 receptor: Differences in binding properties between fibroblastic and thymoma cells and evidence for a two‐chain receptor model

1987 • 56 citations

Evidence that extracellular cathepsin D is not responsible for the resorption of cartilage matrix in culture

1982 • 33 citations

Effect of synthetic metalloprotease inhibitors on cartilage autolysis in vitro.

1987 • 32 citations