Introduction to the Proteasome and its Inhibitors

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

2002 • 4,069 citations

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

2001 • 3,292 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

2001 • 1,714 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

Proteasome inhibitors: from research tools to drug candidates

2001 • 1,159 citations

Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway

1996 • 1,149 citations

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

2001 • 1,088 citations

Posttranslational Quality Control: Folding, Refolding, and Degrading Proteins

1999 • 1,064 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26 S Proteasome

2002 • 983 citations

Cellular Defenses against Unfolded Proteins

2001 • 979 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

AAA⁺ superfamily ATPases: common structure–diverse function

2001 • 953 citations

Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity

1999 • 914 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

NF-κB signaling pathways in mammalian and insect innate immunity

2001 • 892 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States

1999 • 734 citations

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

1995 • 609 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

1987 • 542 citations

Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes

1985 • 521 citations

An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

2002 • 518 citations

Structural basis for the activation of 20S proteasomes by 11S regulators

2000 • 503 citations

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues

2002 • 486 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance

1997 • 464 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

The mechanism and functions of ATP‐dependent proteases in bacterial and animal cells

1992 • 450 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

2001 • 413 citations

Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome)

1988 • 404 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity

1996 • 362 citations

The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides

2002 • 345 citations

Hybrid Proteasomes

2000 • 342 citations

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

2000 • 330 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

2001 • 322 citations

Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

1998 • 318 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

Protein Turnover in Skeletal Muscle

1969 • 317 citations

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

1997 • 315 citations

Degradation of Abnormal Proteins in Escherichia coli

1972 • 298 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

1997 • 295 citations

The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70

1997 • 285 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

1998 • 266 citations

The proteasome activator 11 S REG (PA28) and Class I antigen presentation

1999 • 262 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

Endoplasmic reticulum degradation: reverse protein flow of no return

1997 • 256 citations

ATP Hydrolysis by the Proteasome Regulatory Complex PAN Serves Multiple Functions in Protein Degradation

2003 • 248 citations

Proteins Are Unfolded on the Surface of the ATPase Ring before Transport into the Proteasome

2001 • 235 citations

Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes

2002 • 209 citations

Conformational constraints in protein degradation by the 20S proteasome

1995 • 202 citations

In Vivo Assembly of the Proteasomal Complexes, Implications for Antigen Processing

1995 • 193 citations

An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes

1999 • 174 citations

Binding of Hydrophobic Peptides to Several Non-catalytic Sites Promotes Peptide Hydrolysis by All Active Sites of 20 S Proteasomes

2002 • 173 citations

Regulatory Subunits of Energy-Dependent Proteases

1997 • 169 citations

Involvement of the proteasome in various degradative processes in mammalian cells.

1989 • 162 citations

Identification and partial purification of an ATP-stimulated alkaline protease in rat liver.

1979 • 149 citations

The Regulatory Complex of Drosophila melanogaster 26s Proteasomes

2000 • 145 citations

Why Does Threonine, and Not Serine, Function as the Active Site Nucleophile in Proteasomes?

2000 • 122 citations

The role of nuclear factor-?b in the biology and treatment of multiple myeloma

2001 • 119 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Not just research tools—proteasome inhibitors offer therapeutic promise

2002 • 98 citations

The proteasome activator 11 S REG (PA28) and Class I antigen presentation

2000 • 93 citations

Biochemical and Physical Properties of theMethanococcus jannaschii20S Proteasome and PAN, a Homolog of the ATPase (Rpt) Subunits of the Eucaryal 26S Proteasome

2000 • 86 citations

Proteasomes: The World of Regulatory Proteolysis

2000 • 76 citations

A Role of Aminoacyl-tRNA in the Regulation of Protein Breakdown in Escherichia coli

1971 • 75 citations

A soluble ATP-dependent system for protein degradation from murine erythroleukemia cells. Evidence for a protease which requires ATP hydrolysis but not ubiquitin.

1985 • 70 citations

Proteasomes in Prokaryotes

2000 • 9 citations

The Proteasome Inhibitors and Their Uses

2000 • 3 citations