AAA⁺ superfamily ATPases: common structure–diverse function

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

AAA⁺: A Class of Chaperone-Like ATPases Associated with the Assembly, Operation, and Disassembly of Protein Complexes

1999 • 1,793 citations

Hsp104, Hsp70, and Hsp40

1998 • 1,346 citations

Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

1996 • 1,103 citations

Posttranslational Quality Control: Folding, Refolding, and Degrading Proteins

1999 • 1,064 citations

The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein

1997 • 1,010 citations

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

2000 • 994 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

Spastic Paraplegia and OXPHOS Impairment Caused by Mutations in Paraplegin, a Nuclear-Encoded Mitochondrial Metalloprotease

1998 • 804 citations

A chromatin remodelling complex involved in transcription and DNA processing

2000 • 796 citations

A Yeast Mutant Showing Diagnostic Markers of Early and Late Apoptosis

1997 • 788 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

1998 • 746 citations

Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia

1999 • 608 citations

The Structure of ClpP at 2.3 Å Resolution Suggests a Model for ATP-Dependent Proteolysis

1997 • 603 citations

Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

1999 • 578 citations

Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice

1997 • 549 citations

Structure and Function of Hexameric Helicases

2000 • 545 citations

Winged helix proteins

2000 • 515 citations

Aaa Proteins

2000 • 511 citations

Identification of katanin, an ATPase that severs and disassembles stable microtubules

1993 • 490 citations

The base of the proteasome regulatory particle exhibits chaperone-like activity

1999 • 485 citations

The AAA team: related ATPases with diverse functions

1998 • 475 citations

Crystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides

2000 • 472 citations

A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

2000 • 438 citations

p47 is a cofactor for p97-mediated membrane fusion

1997 • 436 citations

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function

2000 • 432 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

The structures of HslU and the ATP-dependent protease HslU–HslV

2000 • 417 citations

Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis

1999 • 416 citations

Structure of the AAA ATPase p97

2000 • 414 citations

The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

2001 • 413 citations

The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum

2000 • 403 citations

Regulation of Chromosome Replication

2000 • 402 citations

The AAA team: related ATPases with diverse functions

1998 • 402 citations

ATP-Dependent Proteases Degrade Their Substrates by Processively Unraveling Them from the Degradation Signal

2001 • 392 citations

Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

1995 • 382 citations

The G2-phase DNA-damage checkpoint

2000 • 365 citations

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1994 • 358 citations

An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic golgi fragments

1995 • 354 citations

A 200‐amino acid ATPase module in search of a basic function

1995 • 339 citations

Dynamics of Substrate Denaturation and Translocation by the ClpXP Degradation Machine

2000 • 336 citations

Katanin, a Microtubule-Severing Protein, Is a Novel AAA ATPase that Targets to the Centrosome Using a WD40-Containing Subunit

1998 • 332 citations

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

2000 • 330 citations

A Specificity-Enhancing Factor for the ClpXP Degradation Machine

2000 • 328 citations

Prohibitins Regulate Membrane Protein Degradation by the m-AAA Protease in Mitochondria

1999 • 317 citations

An ATPase/Helicase Complex Is an Essential Cofactor for Oncogenic Transformation by c-Myc

2000 • 314 citations

Crystal Structure of the Hexamerization Domain of N-ethylmaleimide–Sensitive Fusion Protein

1998 • 313 citations

A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase

2000 • 311 citations

Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

1998 • 306 citations

Homology in Structural Organization BetweenE. coliClpAP Protease and the Eukaryotic 26 S Proteasome

1995 • 303 citations

The Initiator Function of DnaA Protein Is Negatively Regulated by the Sliding Clamp of the E. coli Chromosomal Replicase

1998 • 300 citations

Crystal and Solution Structures of an HslUV Protease–Chaperone Complex

2000 • 297 citations

Chaperonin Function: Folding by Forced Unfolding

1999 • 294 citations

The RssB response regulator directly targets ς^S for degradation by ClpXP

2001 • 288 citations

Enzymatic and Structural Similarities between theEscherichia coli ATP-dependent Proteases, ClpXP and ClpAP

1998 • 280 citations

Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes

2000 • 269 citations

Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

2001 • 263 citations

Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.

1995 • 262 citations

Heat-inactivated proteins are rescued by the DnaK⋅J-GrpE set and ClpB chaperones

1999 • 252 citations

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP

2000 • 249 citations

ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking

2000 • 249 citations

Characterization of the Five Replication Factor C Genes of Saccharomyces cerevisiae

1995 • 248 citations

Crystal Structure of the δ′ Subunit of the Clamp-Loader Complex of E. coli DNA Polymerase III

1997 • 248 citations

Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP

1998 • 243 citations

Crystal Structures of the HslVU Peptidase–ATPase Complex Reveal an ATP-Dependent Proteolysis Mechanism

2001 • 233 citations

Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders

1997 • 230 citations

Structure and Function of Cdc6/Cdc18

2000 • 228 citations

Microtubule Disassembly by ATP-Dependent Oligomerization of the AAA Enzyme Katanin

1999 • 228 citations

AAA proteases: cellular machines for degrading membrane proteins

2000 • 224 citations

Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease

1999 • 219 citations

Membrane Protein Degradation by AAA Proteases in Mitochondria

2000 • 212 citations

A novel Rad24 checkpoint protein complex closely related to replication factor C

2000 • 208 citations

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies.

1996 • 205 citations

The formation of golgi stacks from vesiculated golgi membranes requires two distinct fusion events

1995 • 205 citations

Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity

1999 • 205 citations

Dissecting the Role of a Conserved Motif (the Second Region of Homology) in the AAA Family of ATPases

1999 • 194 citations

Recognition of Misfolding Proteins by PA700, the Regulatory Subcomplex of the 26 S Proteasome

2000 • 191 citations

MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis

2000 • 188 citations

The Mouse SKD1, a Homologue of Yeast Vps4p, Is Required for Normal Endosomal Trafficking and Morphology in Mammalian Cells

2000 • 186 citations

Crystal structure of heat shock locus V (HslV) from Escherichia coli

1997 • 182 citations

The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome

1997 • 182 citations

Lon and Clp family proteases and chaperones share homologous substrate-recognition domains

1999 • 177 citations

Holliday Junction Processing in Bacteria: Insights from the Evolutionary Conservation of RuvABC, RecG, and RusA

1999 • 174 citations

Visualization of Substrate Binding and Translocation by the ATP-Dependent Protease, ClpXP

2000 • 172 citations

Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU

2001 • 166 citations

Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli

1993 • 162 citations

The Peroxisome Biogenesis Factors Pex4p, Pex22p, Pex1p, and Pex6p Act in the Terminal Steps of Peroxisomal Matrix Protein Import

2000 • 160 citations

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP

2000 • 154 citations

A Major Conformational Change in p97 AAA ATPase upon ATP Binding

2000 • 152 citations

The dynein heavy chain: structure, mechanics and evolution

2001 • 149 citations

ClpA mediates directional translocation of substrate proteins into the ClpP protease

2001 • 148 citations

Fusion of Small Peroxisomal Vesicles in Vitro Reconstructs an Early Step in the in Vivo Multistep Peroxisome Assembly Pathway of Yarrowia lipolytica

2000 • 143 citations

Mitochondrial Hsp78, a member of the Clp/Hsp100 family in Saccharomyces cerevisiae, cooperates with Hsp70 in protein refolding

2001 • 141 citations

At Sixes and Sevens: Characterization of the Symmetry Mismatch of the ClpAP Chaperone-Assisted Protease

1998 • 140 citations

Mutational studies on HslU and its docking mode with HslV

2000 • 136 citations

Disruption of a PEX1–PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease

1998 • 134 citations

Proteolysis of the phage λ CII regulatory protein by FtsH (HflB) of Escherichia coli

1997 • 133 citations

Structural characterization of a dynein motor domain

1998 • 132 citations

Arrangement of Subunits in 20 S Particles Consisting of NSF, SNAPs, and SNARE Complexes

1998 • 130 citations

Processive replication is contingent on the exonuclease subunit of DNA polymerase III holoenzyme.

1990 • 128 citations

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits

1999 • 128 citations

Translocation pathway of protein substrates in ClpAP protease

2001 • 126 citations

Homozygosity Mapping of a Gene Locus for Primary Ciliary Dyskinesia on Chromosome 5p and Identification of the Heavy Dynein Chain DNAH5 as a Candidate Gene

2000 • 123 citations

Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA

1998 • 118 citations

A novel assembly mechanism for the DNA polymerase III holoenzyme DnaX complex: association of deltadelta' with DnaX4 forms DnaX3deltadelta'

2000 • 117 citations

NSF N-Terminal Domain Crystal Structure

1999 • 117 citations

Subunit-specific degradation of the UmuD/D′ heterodimer by the ClpXP protease: the role of trans recognition in UmuD′ stability

2000 • 116 citations

AAA domains and organization of the dynein motor unit

2000 • 115 citations

ATPase switches controlling DNA replication initiation

2000 • 114 citations

Six‐fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP‐dependent activator, ClpY

1996 • 108 citations

Dislocation of membrane proteins in FtsH-mediated proteolysis

1999 • 108 citations

The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development

2000 • 100 citations

Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8

2001 • 96 citations

Crystal structure of the hexameric replicative helicase RepA of plasmid RSF101011Edited by R. Huber

2001 • 95 citations

The solution structure of VAT-N reveals a ‘missing link’ in the evolution of complex enzymes from a simple βαββ element

1999 • 93 citations

Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein

1999 • 93 citations

Cellular Samurai: katanin and the severing of microtubules

2000 • 90 citations

Inhibition of Ubiquitin-mediated Proteolysis by the Arabidopsis 26 S Protease Subunit S5a

1995 • 90 citations

Recognition, Targeting, and Hydrolysis of the λ O Replication Protein by the ClpP/ClpX Protease

1999 • 88 citations

The Janus Face of the Archaeal Cdc48/p97 Homologue VAT: Protein Folding versus Unfolding

1999 • 85 citations

Functional and Physical Interaction between Rad24 and Rfc5 in the Yeast Checkpoint Pathways

1998 • 85 citations

A ring-opening mechanism for DNA binding in the central channel of the T7 helicase-primase protein

2000 • 84 citations

Large T-Antigen Double Hexamers Imaged at the Simian Virus 40 Origin of Replication

2000 • 83 citations

Structure and subunit composition of theRuvAB-holliday junction complex 1 1Edited by P. E. Wright

1997 • 81 citations

Heptameric ring structure of the heat-shock protein ClpB, a protein-activated ATPase in Escherichia coli

2000 • 79 citations

Protein-only inheritance in yeast: something to get [PSI+]-ched about

2000 • 76 citations

ORC5L, a New Member of the Human Origin Recognition Complex, Is Deleted in Uterine Leiomyomas and Malignant Myeloid Diseases

1998 • 74 citations

Structure and mechanism of ATP-dependent proteases

1999 • 73 citations

ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C

2000 • 71 citations

A Cytoplasmic AAA Family Peroxin, Pex1p, Interacts with Pex6p

1998 • 69 citations

Mechanism of β Clamp Opening by the δ Subunit ofEscherichia coli DNA Polymerase III Holoenzyme

2001 • 67 citations

Scanning Transmission Electron Microscopy and Small-Angle Scattering Provide Evidence that Native Escherichia coli ClpP is a Tetradecamer with an Axial Pore

1995 • 61 citations

The HslU ATPase acts as a molecular chaperone in prevention of aggregation of SulA, an inhibitor of cell division in Escherichia coli

2000 • 57 citations

Two Different Oligomeric States of the RuvB Branch Migration Motor Protein as Revealed by Electron Microscopy

2000 • 57 citations

Concurrent Chaperone and Protease Activities of ClpAP and the Requirement for the N-terminal ClpA ATP Binding Site for Chaperone Activity

1999 • 54 citations

Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modelling and mutagenesis

2001 • 51 citations

Length recognition at the N‐terminal tail for the initiation of FtsH‐mediated proteolysis

2000 • 49 citations

The Saccharomyces cerevisiae RuvB-like Protein, Tih2p, Is Required for Cell Cycle Progression and RNA Polymerase II-directed Transcription

2000 • 48 citations

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death

1999 • 47 citations

Mutational analysis of the functional motifs of RuvB, an AAA⁺ class helicase and motor protein for Holliday junction branch migration

2000 • 44 citations

Crystal structure of the Sec18p N-terminal domain

1999 • 40 citations

F0F1-ATP synthase: general structural features of ‘ATP-engine’ and a problem on free energy transduction

2000 • 34 citations

p97 ATPase, an ATPase involved in membrane fusion, interacts with DNA unwinding factor (DUF) that functions in DNA replication

2000 • 33 citations

Here’s the hook: Similar substrate binding sites in the chaperone domains of Clp and Lon

1999 • 29 citations

Protein–protein interactions in intracellular membrane fusion

2000 • 29 citations

Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8

2001 • 24 citations

A handle on NSF

1999 • 14 citations

Ventilatory care in a selection of ontario hospitals: bigger is not necessarily better!

1998 • 11 citations