Extracellular Signals and Pancreatic β-cell Development: A Brief Review

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

2002 • 5,594 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

Controlling TGF-β signaling

2000 • 1,522 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

2000 • 1,416 citations

Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix

1992 • 1,381 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin

1993 • 1,352 citations

Form and function: The laminin family of heterotrimers

2000 • 1,226 citations

Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells

2001 • 1,218 citations

Notch signalling controls pancreatic cell differentiation

1999 • 1,147 citations

Control of endodermal endocrine development by Hes-1

2000 • 1,135 citations

Induction of Pancreatic Differentiation by Signals from Blood Vessels

2001 • 1,052 citations

Notch Signaling: From the Outside In

2000 • 958 citations

Developmental biology of the pancreas

1995 • 942 citations

Growth factors in the extracellular matrix

1997 • 879 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Sensing the environment: a historical perspective on integrin signal transduction

2002 • 855 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Consequences of lack of beta 1 integrin gene expression in mice.

1995 • 724 citations

Signal Transduction and the Control of Gene Expression

2002 • 699 citations

Supramolecular assembly of basement membranes

1996 • 693 citations

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

2000 • 681 citations

The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.

2001 • 670 citations

The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform

1997 • 661 citations

Notochord repression of endodermal Sonic hedgehog permits pancreas development

1998 • 621 citations

A bipotential precursor population for pancreas and liver within the embryonic endoderm

2001 • 607 citations

New aspects of Wnt signaling pathways in higher vertebrates

2001 • 550 citations

Signal transduction by bone morphogenetic proteins

1998 • 528 citations

Extracellular matrix remodelling and cellular differentiation

1999 • 512 citations

Ectodermal Wnt Function as a Neural Crest Inducer

2002 • 507 citations

Pancreatic organogenesis — developmental mechanisms and implications for therapy

2002 • 506 citations

Integrin signaling: specificity and control of cell survival and cell cycle progression

1997 • 474 citations

ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice

1997 • 462 citations

Fgf10is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis

2001 • 452 citations

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

2000 • 443 citations

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

1997 • 443 citations

Rho-family GTPases in cadherin-mediated cell — cell adhesion

2001 • 424 citations

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

1995 • 424 citations

Regulation of pancreas development by hedgehog signaling

2000 • 415 citations

Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning

1998 • 386 citations

Integrins as receptors for laminins

2000 • 369 citations

Positive and negative regulation of TGF-β signaling

2000 • 333 citations

Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development

1999 • 330 citations

The β cell transcription factors and development of the pancreas

1997 • 322 citations

Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development

1998 • 281 citations

Fibroblast Growth Factor Receptor 2-IIIb Acts Upstream of Shh and Fgf4 and Is Required for Limb Bud Maintenance but Not for the Induction of Fgf8, Fgf10, Msx1, or Bmp4

2001 • 262 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function

2001 • 255 citations

FGF signals for cell proliferation and migration through different pathways

2000 • 252 citations

Transcribing pancreas.

1998 • 252 citations

Attenuation of FGF signalling in mouse β-cells leads to diabetes

2000 • 246 citations

Molecular organization at the glycoprotein‐complex‐binding site of dystrophin

1994 • 235 citations

Cadherins regulate aggregation of pancreatic β-cells in vivo

1996 • 233 citations

Synergistic activities of α3 and α6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse

1999 • 233 citations

Structure-Function relationships for the EGF/TGF-α family of mitogens

1994 • 215 citations

Activin receptor patterning of foregut organogenesis

2000 • 213 citations

Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors

2000 • 212 citations

Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement Membranes

1994 • 202 citations

Heparin-binding EGF-like growth factor: a juxtacrine growth factor

2000 • 201 citations

Laminins: Structure and genetic regulation

2000 • 196 citations

Distribution of Dystroglycan in Normal Adult Mouse Tissues

1998 • 195 citations

Ski/Sno and TGF-β signaling

2001 • 192 citations

Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas

1999 • 189 citations

Non-muscle alpha-dystroglycan is involved in epithelial development.

1995 • 186 citations

Hedgehog signal transduction: recent findings

2002 • 183 citations

Molecular cloning of the human α6 integrin subunit

1991 • 183 citations

In-vitro differentiation of pancreatic β-cells

2001 • 179 citations

Neural Cell Adhesion Molecule (N-CAM) Is Required for Cell Type Segregation and Normal Ultrastructure in Pancreatic Islets

1999 • 171 citations

Growth Factor/Matrix-Induced Proliferation of Human Adult β-Cells

1995 • 169 citations

Laminin α1-Chain Shows a Restricted Distribution in Epithelial Basement Membranes of Fetal and Adult Human Tissues

2000 • 164 citations

Regulation of Proliferation and Differentiation of Human Fetal Pancreatic Islet Cells by Extracellular Matrix, Hepatocyte Growth Factor, and Cell-Cell Contact

1996 • 158 citations

Expression and Function of αvβ3 and αvβ5 Integrins in the Developing Pancreas

2000 • 157 citations

Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants.

1998 • 154 citations

Epidermal Growth Factor Increases Undifferentiated Pancreatic Embryonic Cells In Vitro

2001 • 148 citations

Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.

1999 • 147 citations

Sustained proliferation of PDX-1+ cells derived from human islets.

1999 • 147 citations

The ErbB receptor tyrosine family as signal integrators.

2001 • 139 citations

Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood

2002 • 137 citations

Molecular Organization of Sarcoglycan Complex in Mouse Myotubes in Culture

1998 • 131 citations

Cooperation between soluble factors and integrin‐mediated cell anchorage in the control of cell growth and differentiation

1996 • 130 citations

Notch gene expression during pancreatic organogenesis

2000 • 129 citations

Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation

2002 • 129 citations

Structure-function and biological role of betacellulin

2000 • 122 citations

KSA Antigen Ep-CAM Mediates Cell–Cell Adhesion of Pancreatic Epithelial Cells: Morphoregulatory Roles in Pancreatic Islet Development

1998 • 110 citations

Multiple levels of Notch signal regulation (Review)

2002 • 106 citations

Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme

2000 • 106 citations

Notch and Presenilin: a proteolytic mechanism emerges

2001 • 106 citations

Restricted distribution of laminin α1 chain in normal adult mouse tissues

1999 • 104 citations

Pancreatic Development and Adult Diabetes

2000 • 98 citations

Induction of ureter branching as a response to Wnt‐2b signaling during early kidney organogenesis

2001 • 97 citations

Distinct Distribution of Laminin and Its Integrin Receptors in the Pancreas

2002 • 93 citations

Receptors for laminins during epithelial morphogenesis

1996 • 91 citations

Integrin adhesion receptors: structure, function and implications for biomedicine

1996 • 87 citations

Dystrophin-Glycoprotein Complex Is Monomeric and Stabilizes Actin Filaments in Vitro through a Lateral Association

1997 • 87 citations

Cell Density and N-Cadherin Interactions Regulate Cell Proliferation in the Sensory Epithelia of the Inner Ear

2002 • 72 citations

Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development

1997 • 71 citations

Dystrophic phenotype induced in vitro by antibody blockade of muscle α-dystroglycan-laminin interaction

1999 • 70 citations

Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression

2000 • 68 citations

Expression of ErbB receptors during pancreatic islet development and regrowth

2000 • 66 citations

Pancreatic morphogenesis and extracellular matrix organization during rat development

1993 • 61 citations

Regulation of Laminin 1-Induced Pancreatic β-Cell Differentiation by α6 Integrin and α-Dystroglycan

2001 • 56 citations

In vivo presence of the high affinity nerve growth factor receptor Trk-A in the rat pancreas: differential localization during pancreatic development.

1995 • 56 citations

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

2002 • 56 citations

Protein kinase mediators of integrin signal transduction

1997 • 50 citations

Dystroglycan and Laminins: Glycoconjugates Involved in Branching Epithelial Morphogenesis

1997 • 49 citations

Transforming growth factor-β1 in the developing mouse pancreas: a potential regulator of exocrine differentiation

2000 • 44 citations

Tissue Restricted Expression of Two Human Frzbs in Preadipocytes and Pancreas

1998 • 41 citations

On the development of the Islets of Langerhans

1998 • 36 citations

Development of pancreas

1997 • 29 citations

Transgenic Expression of FGF8 and FGF10 Induces Transdifferentiation of Pancreatic Islet Cells into Hepatocytes and Exocrine Cells

2002 • 24 citations

Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus

2001 • 21 citations

Wnt signaling: The Naked truth?

2001 • 20 citations

Development of embryonic chick insulin cells in culture: Beneficial effects of serum-free medium, raised nutrients, and biomatrix

1997 • 14 citations

Fibroblast Growth Factor 2 Promotes Pancreatic Epithelial Cell Proliferation Via Functional Fibroblast Growth Factor Receptors During Embryonic Life

1998 • 10 citations

Inhibition of pig granulosa cell adhesion and growth in vitro by immunoneutralization of epithelial cadherin

2000 • 8 citations