A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Dystrophin: The protein product of the duchenne muscular dystrophy locus

1987 • 4,477 citations

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein

1988 • 1,501 citations

Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix

1992 • 1,381 citations

Membrane organization of the dystrophin-glycoprotein complex

1991 • 1,321 citations

Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle

1990 • 996 citations

The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy

1991 • 892 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding

1987 • 677 citations

A Synthetic Peptide Containing the IKVAV Sequence from the A Chain of Laminin Mediates Cell Attachment, Migration, and Neurite Outgrowth

1989 • 623 citations

Duchenne muscular dystrophy: Deficiency of dystrophin at the muscle cell surface

1988 • 617 citations

Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere.

1990 • 588 citations

Adhesive recognition sequences

1991 • 571 citations

Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+-permeable pore of the calcium release channel.

1987 • 503 citations

Glycoprotein Complex Anchoring Dystrophin to Sarcolemma1

1990 • 500 citations

Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle

1992 • 489 citations

Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs

1991 • 486 citations

An autosomal transcript in skeletal muscle with homology to dystrophin

1989 • 478 citations

Immunoelectron microscopic localization of dystrophin in myofibres

1988 • 447 citations

Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx mice.

1991 • 424 citations

Staining of the Ca2+-binding proteins, calsequestrin, calmodulin, troponin C, and S-100, with the cationic carbocyanine dye “Stains-all”.

1983 • 422 citations

Localization of dystrophin to postsynaptic regions of central nervous system cortical neurons

1990 • 413 citations

Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.

1990 • 398 citations

Calcium entry through stretch-inactivated ion channels in mdx myotubes

1990 • 394 citations

Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle

1991 • 368 citations

Isolation of a laminin-binding protein from muscle cell membranes

1983 • 354 citations

Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits.

1990 • 346 citations

Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse

1991 • 331 citations

Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.

1991 • 281 citations

Increased calcium influx in dystrophic muscle.

1991 • 271 citations

Duchenne muscular dystrophy

1993 • 260 citations

Deficiency of the 50K dystrophin-associated glycoprotein in severe childhood autosomal recessive muscular dystrophy

1992 • 250 citations

Receptors for laminin on mammalian cells

1991 • 236 citations

A 71-kilodalton protein is a major product of the Duchenne muscular dystrophy gene in brain and other nonmuscle tissues.

1992 • 234 citations

Identification and characterization of the high affinity [3H]ryanodine receptor of the junctional sarcoplasmic reticulum Ca2+ release channel.

1987 • 229 citations

Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle

1992 • 229 citations

The subcellular distribution of dystrophin in mouse skeletal, cardiac, and smooth muscle.

1991 • 228 citations

Dystrophin-deficient mdx muscle fibers are preferentially vulnerable to necrosis induced by experimental lengthening contractions

1990 • 221 citations

Glycoprotein‐binding site of dystrophin is confined to the cysteine‐rich domain and the first half of the carboxy‐terminal domain

1992 • 210 citations

Gamma actin, spectrin, and intermediate filament proteins colocalize with vinculin at costameres, myofibril‐to‐sarcolemma attachment sites

1983 • 201 citations

Analysis of the actin-binding domain of alpha-actinin by mutagenesis and demonstration that dystrophin contains a functionally homologous domain.

1992 • 182 citations

Autophosphorylation of Ca2+/calmodulin-dependent protein kinase II. Effects on total and Ca2+-independent activities and kinetic parameters.

1987 • 174 citations

Purification of dystrophin from skeletal muscle

1991 • 172 citations

A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility

1992 • 168 citations

Centractin is an actin homologue associated with the centrosome

1992 • 164 citations

Cranin: a laminin-binding protein of cell membranes.

1987 • 161 citations

Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.

1987 • 161 citations

Dystrophin and the membrane skeleton

1993 • 159 citations

Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin.

1991 • 158 citations

Identification of the Arg‐Gly‐Asp sequence in laminin A chain as a latent cell‐binding site being exposed in fragment P1

1990 • 150 citations

Expression of the N‐terminal domain of dystrophin in E. coli and demonstration of binding to F‐actin

1992 • 144 citations

Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.

1991 • 140 citations

A role for collagen in the pathogenesis of muscular dystrophy?

1980 • 130 citations

Binding sites involved in the interaction of actin with the N‐terminal region of dystrophin

1992 • 127 citations

The identification and sequence of the actin-binding domain of human red blood cell beta-spectrin.

1990 • 123 citations

Dystrophin-glycoprotein complex and laminin colocalize to the sarcolemma and transverse tubules of cardiac muscle.

1993 • 122 citations

Characterization of a 4.8kb transcript from the Duchenne muscular dystrophy locus expressed in Schwannoma cells

1992 • 119 citations

Characterization of synapsin I fragments produced by cysteine-specific cleavage: a study of their interactions with F-actin.

1989 • 115 citations

The visualization of human erythrocyte membrane proteins and glycoproteins in SDS polyacrylamide gels employing a single staining procedure

1976 • 105 citations

Localization of three distinct heparin-binding domains of laminin by monoclonal antibodies.

1988 • 104 citations

Accumulation of collagen and altered fiber‐type ratios as indicators of abnormal muscle gene expression in the mdx dystrophic mouse

1989 • 98 citations

Isolation and characterization of human heparin

1992 • 94 citations

Identification of a short sequence essential for actin binding by Dictyostelium ABP-120.

1990 • 93 citations

Isolation and partial characterization of high affinity laminin receptors in neural cells.

1988 • 92 citations

Expression of the Duchenne's muscular dystrophy gene in cultured muscle cells.

1987 • 88 citations

Structure of laminin variants. The 300-kDa chains of murine and bovine heart laminin are related to the human placenta merosin heavy chain and replace the a chain in some laminin variants.

1991 • 84 citations

Abnormal expression of dystrophin-associated proteins in Fukuyama-type congenital muscular dystrophy

1993 • 84 citations

Dystrophin constitutes 5% of membrane cytoskeleton in skeletal muscle

1991 • 83 citations

Expression of recombinant dystrophin and its localization to the cell membrane

1991 • 82 citations

Isolation of α6β1 integrins from platelets and adherent cells by affinity chromatography on mouse laminin fragment E8 and human laminin pepsin fragment

1991 • 80 citations

Keratan sulfate proteoglycan in rabbit compact bone is bone sialoprotein II.

1987 • 80 citations

The molecular and biochemical basis of Duchenne muscular dystrophy

1992 • 73 citations

The α5β1 integrin associates with a dystrophin-containing lattice during muscle development

1992 • 73 citations

Characterization and cell type distribution of a novel, major transcript of the Duchenne Muscular Dystrophy gene

1992 • 72 citations

Basement membranes

1987 • 71 citations

Mapping of three major heparin-binding sites on laminin and identification of a novel heparin-binding site on the B1 chain

1989 • 68 citations

Calmodulin-binding proteins: Visualization by 125I-calmodulin overlay on blots quenched with tween 20 or bovine serum albumin and poly(ethylene oxide)

1984 • 67 citations

Characterization of a novel heparan sulfate proteoglycan found in the extracellular matrix of liver sinusoids and basement membranes.

1991 • 57 citations

Dystrophin is a component of the subsynaptic membrane.

1991 • 52 citations

Identification of novel proteins unique to either transverse tubules (TS28) or the sarcolemma (SL50) in rabbit skeletal muscle.

1990 • 50 citations

Co-localization and molecular association of dystrophin with laminin at the surface of mouse and human myotubes

1992 • 48 citations

Calmodulin specifically binds three proteins of the dystrophin-glycoprotein complex

1992 • 47 citations

Locomotory competence and laminin-specific cell surface binding sites are lost during myoblast differentiation

1989 • 39 citations

Characterization of calcium binding to brain spectrin.

1992 • 31 citations

Structure, calmodulin-binding, and calcium-binding properties of recombinant alpha spectrin polypeptides.

1991 • 31 citations

A comparative analysis of collagen III, IV, laminin and fibronectin in Duchenne muscular dystrophy biopsies and cell cultures.

1986 • 27 citations

Mucin-like glycoprotein secreted by cultured hamster tracheal epithelial cells. Biochemical and immunological characterization

1991 • 25 citations

The large glycoprotein subunit of the skeletal muscle voltage‐sensitive calcium channel

1988 • 23 citations

Electrophoresis and detection of nanogram quantities of exogenous and endogenous glycosaminoglycans in biological fluids.

1991 • 20 citations

Extra actin filaments at the periphery of skeletal muscle myofibrils

1991 • 18 citations