FGF signals for cell proliferation and migration through different pathways

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.

1996 • 769 citations

Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

1996 • 764 citations

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

1999 • 644 citations

branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

1996 • 631 citations

Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects

1995 • 553 citations

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1997 • 544 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

Signal transduction by fibroblast growth factor receptors

1999 • 419 citations

The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and Function

1997 • 400 citations

Keratinocyte Growth Factor: A Unique Player in Epithelial Repair Processes

1998 • 345 citations

Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages.

1996 • 303 citations

heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo.

1996 • 298 citations

FGF-19, A NOVEL FIBROBLAST GROWTH FACTOR WITH UNIQUE SPECIFICITY FOR FGFR4

1999 • 290 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration.

1986 • 272 citations

The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension.

1991 • 217 citations

Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells.

1989 • 210 citations

Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms.

1995 • 209 citations

Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells.

1990 • 205 citations

Assays for angiogenesis: A review

1991 • 202 citations

The plasminogen-plasmin system in malignancy

1992 • 190 citations

An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites

1995 • 183 citations

Keratinocyte growth factor and its receptor are involved in regulating early lung branching

1996 • 150 citations

p38 Mitogen-activated Protein Kinase Activation Is Required for Fibroblast Growth Factor-2-stimulated Cell Proliferation but Not Differentiation

1999 • 144 citations

The mitogenic signaling pathway but not the plasminogen activator-inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells.

1989 • 133 citations

Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration

1998 • 131 citations

The Role of Syndecan Cytoplasmic Domain in Basic Fibroblast Growth Factor-dependent Signal Transduction

1999 • 125 citations

Roles of Extracellular Signal‐regulated Kinase 1/2 and p38 Mitogen‐activated Protein Kinase in the Signal Transduction of Basic Fibroblast Growth Factor in Endothelial Cells during Angiogenesis

1999 • 122 citations

Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation

1999 • 120 citations

The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development

1999 • 116 citations

Cell Migration and Chick Limb Development: Chemotactic Action of FGF-4 and the AER

1999 • 114 citations

Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity.

1994 • 86 citations

Src is required for cell migration and shape changes induced by fibroblast growth factor 1

1999 • 84 citations

A six-amino acid deletion in basic fibroblast growth factor dissociates its mitogenic activity from its plasminogen activator-inducing capacity.

1991 • 83 citations

Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.

1995 • 82 citations

pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line.

1995 • 81 citations

Transplanted Oligodendrocyte Progenitor Cells Expressing a Dominant-Negative FGF Receptor Transgene Fail to MigrateIn Vivo

1997 • 73 citations

The Nonreceptor Protein-tyrosine Kinase c-Fes Is Involved in Fibroblast Growth Factor-2-induced Chemotaxis of Murine Brain Capillary Endothelial Cells

2000 • 65 citations

The 27-kDa Heat Shock Protein Facilitates Basic Fibroblast Growth Factor Release from Endothelial Cells

1997 • 65 citations

Signaling via Fibroblast Growth Factor Receptor-1 Is Dependent on Extracellular Matrix in Capillary Endothelial Cell Differentiation

1999 • 60 citations

Regulation of Basic Fibroblast Growth Factor Binding and Activity by Cell Density and Heparan Sulfate

1999 • 58 citations

Ets-1 transcription factor-mediated urokinase-type plasminogen activator expression and invasion in glioma cells stimulated by serum and basic fibroblast growth factors.

1999 • 57 citations

Control of cell migration during Caenorhabditis elegans development

1999 • 55 citations

Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding

1998 • 51 citations

Wound reepithelialization activates a growth factor‐responsive enhancer in migrating keratinocytes

1998 • 50 citations

Cyclic AMP distinguishes between two functions of acidic FGF in a rat bladder carcinoma cell line.

1993 • 47 citations

Growth Factors: Therapeutic Advances in Wound Healing

1993 • 47 citations

Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line.

1990 • 44 citations

Involvement of protein kinase C in the mitogenic and chemotaxis effects of basic fibroblast growth factor on bovine cerebral cortex capillary endothelial cells

1990 • 43 citations

Relationship between cell migration and cell cycle during the initiation of epithelial to fibroblastoid transition

1999 • 41 citations

Characterization of a Novel Member of the FGF Family, XFGF-20, in Xenopus laevis

1999 • 40 citations

Stimulation of tyrosine‐ and serine‐phosphorylation of focal adhesion kinase in mouse 3T3 cells by fibronectin and fibroblast growth factor

1994 • 40 citations

A distinct basic fibroblast growth factor (FGF-2)/FGF receptor interaction distinguishes urokinase-type plasminogen activator induction from mitogenicity in endothelial cells.

1996 • 40 citations

Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation

1997 • 39 citations

Mechanical endothelial damage results in basic fibroblast growth factor–mediated activation of extracellular signal-regulated kinases

1999 • 37 citations

Phospholipase Cγ Activation, Phosphotidylinositol Hydrolysis, and Calcium Mobilization are Not Required for FGF Receptor-Mediated Chemotaxis

1994 • 36 citations

Structure-function relationship of basic fibroblast growth factor: Site-directed mutagenesis of a putative heparin-binding and receptor-binding region

1992 • 31 citations

Different Tyrosine Autophosphorylation Requirements in Fibroblast Growth Factor Receptor-1 Mediate Urokinase-Type Plasminogen Activator Induction and Mitogenesis

1999 • 30 citations

Moving right along: regulation of cell migration during Drosophila development

1994 • 28 citations

Dual activities of 22-24 kda basic fibroblast growth factor: Inhibition of migration and stimulation of proliferation

1999 • 27 citations

Induction of Urokinase-type Plasminogen Activator by Fibroblast Growth Factor (FGF)-2 Is Dependent on Expression of FGF Receptors and Does Not Require Activation of Phospholipase Cγ1

1996 • 25 citations

Morphogenesis: FGF branches out

1997 • 22 citations

Basic fibroblast growth factor stimulates repair of wounded hepatocyte monolayer: Modulatory role of protein kinase A and extracellular matrix

1999 • 20 citations

Subcellular Localization and Biological Activity of Mr 18,000 Basic Fibroblast Growth Factor: Site-Directed Mutagenesis of a Putative Nuclear Translocation Sequence

1993 • 20 citations

Concentration‐dependent modulation of basic fibroblast growth factor action on multiplication and locomotion of human teratocarcinoma cells

1992 • 16 citations

Heparin Binding Growth Factors and the Control of Teratoma Cell Proliferation

1993 • 6 citations

Implication of scatter/growth factors in tumor progression.

1994 • 1 citations

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