Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Fgf10 is essential for limb and lung formation

1999 • 1,204 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

1997 • 1,011 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

1997 • 690 citations

Notochord repression of endodermal Sonic hedgehog permits pancreas development

1998 • 621 citations

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

1999 • 610 citations

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.

1995 • 601 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1996 • 548 citations

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

1998 • 531 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Epitheliomesenchymal interaction in pancreatic morphogenesis

1962 • 409 citations

Notochord to endoderm signaling is required for pancreas development

1997 • 408 citations

FUNCTIONAL SUBDIVISION OF ISLETS OF LANGERHANS AND POSSIBLE ROLE OF D CELLS

1975 • 408 citations

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

1999 • 285 citations

Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

1995 • 277 citations

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

1999 • 258 citations

Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells

1986 • 256 citations

Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells.

1993 • 248 citations

The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein.

1996 • 234 citations

Extra-insular beta cells associated with ductules are frequent in adult human pancreas

1998 • 229 citations

Embryogenesis of the Human Pancreatic Islets: A Light and Electron Microscopic Study

1972 • 214 citations

Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas

1999 • 189 citations

Proliferation and differentiation in the human fetal endocrine pancreas

1997 • 185 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

1993 • 183 citations

Fibroblast growth factors in mammalian development

1995 • 182 citations

Early pattern of differentiation in the human pancreas.

2000 • 176 citations

Neural Cell Adhesion Molecule (N-CAM) Is Required for Cell Type Segregation and Normal Ultrastructure in Pancreatic Islets

1999 • 171 citations

Pancreatic beta cells express a diverse set of homeobox genes.

1994 • 156 citations

Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells

1989 • 150 citations

The midgestational human fetal pancreas contains cells coexpressing islet hormones

1992 • 127 citations

Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation

1994 • 124 citations

Polyclonal origin of pancreatic islets in aggregation mouse chimaeras

1991 • 105 citations

Pancreas development and diabetes

1999 • 100 citations

Analysis of Pancreatic Development Using a Cell Lineage Label

1999 • 90 citations

A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues.

1994 • 89 citations

Keratinocyte growth factor induces pancreatic ductal epithelial proliferation.

1994 • 88 citations

Ex Vivo Expansion of Human Pancreatic Endocrine Cells

1997 • 66 citations

Quantitative morphology of endocrine cells in human fetal pancreas

1983 • 48 citations

Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact

1996 • 46 citations

Tissue Culture of Human Fetal Pancreas; Effects of Nicotinamide on Insulin Production and Formation of Isletlike Cell Clusters

1989 • 41 citations

Alteration of islet cell populations in spontaneously diabetic mice

1978 • 41 citations

Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells

1994 • 40 citations

Sequential Morphological Changes in Pancreatic Islets of Spontaneously Diabetic Rats

1990 • 40 citations

A quantitative immunofluorescent study of the endocrine cell populations in the developing human pancreas

1983 • 34 citations

Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells

1994 • 34 citations

A morphological and immunohistochemical investigation of endocrine pancreata from obese ob+/ob+ mice

1991 • 33 citations

Tissue culture of human fetal pancreas. Development and function of B-cells in vitro and transplantation of explants to nude mice

1985 • 24 citations

Growth and hormonal content of human fetal pancreas passaged in athymic mice

1986 • 16 citations

Histologic differentiation of human fetal pancreatic explants transplanted into nude mice

1984 • 15 citations

Ontogeny and tissue distribution of human GAD expression

1996 • 13 citations

Fetal pancreatic transplantation

1992 • 11 citations

Morphology, yield and functional integrity of islet-like cell clusters in tissue culture of human fetal pancreata obtained after different means of abortion

1988 • 8 citations

Functional beta-cell mass after transplantation of human fetal pancreatic cells: differentiation or proliferation?

1997 • 5 citations

Developmental Gene Expression of Trypsinogen and Lipase in Human Fetal Pancreas

1997 • 2 citations