Molecular Analyses of Two Poly(A) Site-Processing Factors That Determine the Recognition and Efficiency of Cleavage of the Pre-mRNA

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

COMPLEX TRANSCRIPTIONAL UNITS: DIVERSITY IN GENE EXPRESSION BY ALTERNATIVE RNA PROCESSING

1986 • 486 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

1983 • 278 citations

Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing

1981 • 261 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.

1990 • 243 citations

Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit β-globin mRNA 3′ end formation

1987 • 229 citations

Efficiency of Utilization of the Simian Virus 40 Late Polyadenylation Site: Effects of Upstream Sequences

1989 • 205 citations

3′ cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP

1988 • 205 citations

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

1988 • 195 citations

An ordered pathway of assembly of components required for polyadenylation site recognition and processing.

1989 • 194 citations

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

1988 • 187 citations

Sequences capable of restoring poly(A) site function define two distinct downstream elements.

1986 • 175 citations

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.

1990 • 159 citations

Poly(A) site efficiency reflects the stability of complex formation involving the downstream element.

1991 • 140 citations

A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

1985 • 139 citations

Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding.

1988 • 111 citations

Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development.

1987 • 110 citations

Multiple factors are required for specific RNA cleavage at a poly(A) addition site.

1988 • 106 citations

A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates.

1990 • 87 citations

Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNAs.

1988 • 87 citations

Sequences on the 3′ Side of Hexanucleotide AAUAAA Affect Efficiency of Cleavage at the Polyadenylation Site

1984 • 72 citations

Multiple factors are required for poly(A) addition to a mRNA 3' end.

1988 • 65 citations

Regulation of poly(A) site selection in adenovirus

1989 • 61 citations

The Regulated Production of μ_m and μ_s mRNA Is Dependent on the Relative Efficiencies of μ_s Poly(A) Site Usage and the Cμ4-to-M1 Splice

1989 • 57 citations

Involvement of Long Terminal Repeat U3 Sequences Overlapping the Transcription Control Region in Human Immunodeficiency Virus Type 1 mRNA 3′ End Formation

1991 • 43 citations

The C Proteins of Heterogeneous Nuclear Ribonucleoprotein Complexes Interact with RNA Sequences Downstream of Polyadenylation Cleavage Sites

1988 • 38 citations

Spatial constraints on polyadenylation signal function.

1990 • 30 citations

Analysis of Processing and Polyadenylation Signals of the Hepatitis B Virus Surface Antigen Gene by Using Simian Virus 40-Hepatitis B Virus Chimeric Plasmids

1983 • 28 citations