Poly(A) site efficiency reflects the stability of complex formation involving the downstream element.

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit β-globin mRNA 3′ end formation

1987 • 229 citations

Four factors are required for 3'-end cleavage of pre-mRNAs.

1989 • 217 citations

3′ cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP

1988 • 205 citations

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

1988 • 195 citations

An ordered pathway of assembly of components required for polyadenylation site recognition and processing.

1989 • 194 citations

Sequences capable of restoring poly(A) site function define two distinct downstream elements.

1986 • 175 citations

Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis B virus chimeric plasmids.

1983 • 164 citations

The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice.

1989 • 164 citations

Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.

1984 • 113 citations

Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development.

1987 • 110 citations

Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation.

1984 • 109 citations

Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron.

1986 • 109 citations

Multiple factors are required for specific RNA cleavage at a poly(A) addition site.

1988 • 106 citations

Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro.

1989 • 104 citations

Sequences on the 3′ Side of Hexanucleotide AAUAAA Affect Efficiency of Cleavage at the Polyadenylation Site

1984 • 72 citations

Multiple factors are required for poly(A) addition to a mRNA 3' end.

1988 • 65 citations

The Regulated Production of μ_m and μ_s mRNA Is Dependent on the Relative Efficiencies of μ_s Poly(A) Site Usage and the Cμ4-to-M1 Splice

1989 • 57 citations

Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.

1988 • 53 citations

Effects of intron length on differential processing of mouse mu heavy-chain mRNA.

1987 • 40 citations

Poly(A) Polymerase Purified from HeLa Cell Nuclear Extract Is Required for Both Cleavage and Polyadenylation of Pre-mRNA In Vitro

1989 • 40 citations

Spatial constraints on polyadenylation signal function.

1990 • 30 citations

Role of transcriptional termination in the regulation of mu mRNA expression in B lymphocytes.

1989 • 27 citations

Patterns of Polyadenylation Site Selection in Gene Constructs Containing Multiple Polyadenylation Signals

1988 • 26 citations

Effects of Intron Length on Differential Processing of Mouse μ Heavy-Chain mRNA

1987 • 15 citations