An ordered pathway of assembly of components required for polyadenylation site recognition and processing.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

1983 • 278 citations

Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit β-globin mRNA 3′ end formation

1987 • 229 citations

3′ cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP

1988 • 205 citations

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

1988 • 195 citations

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

1988 • 187 citations

Sequences capable of restoring poly(A) site function define two distinct downstream elements.

1986 • 175 citations

Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis B virus chimeric plasmids.

1983 • 164 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro.

1986 • 147 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.

1984 • 113 citations

Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding.

1988 • 111 citations

Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development.

1987 • 110 citations

Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro.

1989 • 104 citations

Two phases in the addition of a poly(A) tail.

1989 • 98 citations

Analysis of RNA cleavage at the adenovirus-2 L3 polyadenylation site.

1986 • 94 citations

Cleavage and polyadenylation of messenger RNA precursors in vitro occurs within large and specific 3′ processing complexes.

1987 • 88 citations

Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNAs.

1988 • 87 citations

Electrophoretic separation of polyadenylation-specific complexes.

1987 • 84 citations

A beginning to the biochemistry of polyadenylation

1988 • 84 citations

Formation of mRNA 3′ termini: stability and dissociation of a complex involving the AAUAAA sequence.

1987 • 83 citations

Analysis of mRNA 3′ end formation by modification interference: the only modifications which prevent processing lie in AAUAAA and the poly(A) site.

1987 • 77 citations

A rabbit beta-globin polyadenylation signal directs efficient termination of transcription of polyomavirus DNA.

1988 • 70 citations

The AAUAAA Sequence Is Required both for Cleavage and for Polyadenylation of Simian Virus 40 Pre-mRNA In Vitro

1986 • 69 citations

Multiple factors are required for poly(A) addition to a mRNA 3' end.

1988 • 65 citations

Specific pre-cleavage and post-cleavage complexes involved in the formation of SV40 late mRNA 3′ termini in vitro.

1987 • 57 citations

Poly(A) Polymerase Purified from HeLa Cell Nuclear Extract Is Required for Both Cleavage and Polyadenylation of Pre-mRNA In Vitro

1989 • 40 citations

Assembly of a polyadenylation-specific 25S ribonucleoprotein complex in vitro.

1988 • 35 citations

Analysis of Processing and Polyadenylation Signals of the Hepatitis B Virus Surface Antigen Gene by Using Simian Virus 40-Hepatitis B Virus Chimeric Plasmids

1983 • 28 citations

Assembly of a Polyadenylation-Specific 25S Ribonucleoprotein Complex In Vitro

1988 • 20 citations