Sequences capable of restoring poly(A) site function define two distinct downstream elements.

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End Formation

1984 • 561 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

1983 • 278 citations

Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing

1981 • 261 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.

1984 • 202 citations

Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis B virus chimeric plasmids.

1983 • 164 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro.

1986 • 147 citations

A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

1985 • 139 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription.

1985 • 131 citations

Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.

1984 • 113 citations

Targeted random mutagenesis: the use of ambiguously synthesized oligonucleotides to mutagenize sequences immediately 5‘ of an ATG initiation codon

1983 • 112 citations

Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation.

1984 • 109 citations

Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing.

1985 • 105 citations

Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites.

1985 • 102 citations

Calcitonin/Calcitonin Gene-Related Peptide Transcription Unit: Tissue-Specific Expression Involves Selective Use of Alternative Polyadenylation Sites

1984 • 73 citations

Sequences on the 3′ Side of Hexanucleotide AAUAAA Affect Efficiency of Cleavage at the Polyadenylation Site

1984 • 72 citations

The AAUAAA Sequence Is Required both for Cleavage and for Polyadenylation of Simian Virus 40 Pre-mRNA In Vitro

1986 • 69 citations

Mutations downstream of the polyadenylation site of a Xenopus β-globin mRNA affect the position but not the efficiency of 3′ processing

1986 • 63 citations

Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.

1985 • 60 citations

Identification of a Sequence Element on the 3′ Side of AAUAAA Which Is Necessary for Simian Virus 40 Late mRNA 3′-End Processing

1985 • 59 citations

Definition of Essential Sequences and Functional Equivalence of Elements Downstream of the Adenovirus E2A and the Early Simian Virus 40 Polyadenylation Sites

1985 • 51 citations

Adenovirus gene expression: Control at multiple steps of mRNA biogenesis

1982 • 43 citations

Identification of Sequences in the Herpes Simplex Virus Thymidine Kinase Gene Required for Efficient Processing and Polyadenylation

1985 • 41 citations