RETROVIRUS BUDDING

Lipid rafts and signal transduction

2000 • 6,079 citations

Exosomes: composition, biogenesis and function

2002 • 4,840 citations

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

2003 • 1,660 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 Budding

2001 • 1,351 citations

HIV preferentially infects HIV-specific CD4+ T cells

2002 • 1,246 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

2003 • 1,102 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device

2000 • 1,033 citations

The Immunological Synapse

2001 • 987 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

DC-SIGN: escape mechanism for pathogens

2003 • 898 citations

Escrt-III

2002 • 854 citations

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

1992 • 832 citations

The Biogenesis and Functions of Exosomes

2002 • 816 citations

AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus Budding

2003 • 810 citations

The Protein Network of HIV Budding

2003 • 806 citations

Evidence for Budding of Human Immunodeficiency Virus Type 1 Selectively from Glycolipid-Enriched Membrane Lipid Rafts

2000 • 768 citations

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

1998 • 746 citations

Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton

2003 • 711 citations

HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

2001 • 706 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions

2003 • 692 citations

Plasma membrane rafts play a critical role in HIV-1 assembly and release

2001 • 675 citations

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

2004 • 671 citations

Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.

1991 • 644 citations

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

2002 • 629 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse

2004 • 612 citations

The Trojan exosome hypothesis

2003 • 600 citations

Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55 ^Gag

2001 • 576 citations

DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell Infection

2002 • 513 citations

Phosphatidylinositol(3)-Phosphate Signaling Mediated by Specific Binding to RING FYVE Domains

1998 • 497 citations

Protein sorting into multivesicular endosomes

2003 • 496 citations

p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease

1995 • 482 citations

Infectious HIV-1 assembles in late endosomes in primary macrophages

2003 • 477 citations

Virus Entry, Assembly, Budding, and Membrane Rafts

2003 • 474 citations

WW and SH3 domains, two different scaffolds to recognize proline‐rich ligands

2001 • 474 citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

2002 • 468 citations

A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: Implications for filovirus budding

2000 • 449 citations

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

2003 • 448 citations

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

2003 • 445 citations

Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

2002 • 437 citations

Viral Late Domains

2002 • 418 citations

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

2002 • 417 citations

T-cell engagement of dendritic cells rapidly rearranges MHC class II transport

2002 • 416 citations

Fab1p Is Essential for PtdIns(3)P 5-Kinase Activity and the Maintenance of Vacuolar Size and Membrane Homeostasis

1998 • 416 citations

Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p

1997 • 412 citations

Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal Trafficking

2000 • 401 citations

Visualization of Retroviral Replication in Living Cells Reveals Budding into Multivesicular Bodies

2003 • 396 citations

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins

2003 • 390 citations

The E3 Ubiquitin Ligase AIP4 Mediates Ubiquitination and Sorting of the G Protein-Coupled Receptor CXCR4

2003 • 374 citations

Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function

2002 • 349 citations

The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting

2002 • 345 citations

Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

2000 • 334 citations

Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway

2003 • 326 citations

The small RING finger protein Z drives arenavirus budding: Implications for antiviral strategies

2003 • 326 citations

Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

2001 • 324 citations

Human Macrophages Accumulate HIV‐1 Particles in MHC II Compartments

2002 • 320 citations

A role for ubiquitin ligase recruitment in retrovirus release

2000 • 304 citations

The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways

2000 • 299 citations

AAA proteins

2002 • 299 citations

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

2003 • 298 citations

Structure and functional interactions of the Tsg101 UEV domain

2002 • 294 citations

Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study

1988 • 291 citations

Ubiquitin is part of the retrovirus budding machinery

2000 • 288 citations

The Doa4 Deubiquitinating Enzyme Is Required for Ubiquitin Homeostasis in Yeast

1999 • 285 citations

Overlapping Motifs (PTAP and PPEY) within the Ebola Virus VP40 Protein Function Independently as Late Budding Domains: Involvement of Host Proteins TSG101 and VPS-4

2003 • 277 citations

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

2000 • 269 citations

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

2002 • 264 citations

The immune control and cell-to-cell spread of human T-lymphotropic virus type 1

2003 • 257 citations

Positionally independent and exchangeable late budding functions of the Rous sarcoma virus and human immunodeficiency virus Gag proteins

1995 • 255 citations

ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking

2000 • 249 citations

HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein

2003 • 248 citations

An assembly domain of the Rous sarcoma virus Gag protein required late in budding

1994 • 248 citations

Multimerization of Human Immunodeficiency Virus Type 1 Gag Promotes Its Localization to Barges, Raft-Like Membrane Microdomains

2001 • 244 citations

Role of ESCRT-I in Retroviral Budding

2003 • 243 citations

Distinct Functional Surface Regions on Ubiquitin

2001 • 241 citations

Lassa Virus Z Protein Is a Matrix Protein Sufficient for the Release of Virus-Like Particles

2003 • 241 citations

Ubiquitin interactions of NZF zinc fingers

2004 • 240 citations

A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP

2000 • 225 citations

Ubiquitin Recognition by the Human TSG101 Protein

2004 • 221 citations

Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity

1999 • 214 citations

Equine infectious anemia virus utilizes a YXXL motif within the late assembly domain of the Gag p9 protein

1997 • 210 citations

Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae

2003 • 207 citations

Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation

2003 • 205 citations

The ALG-2-interacting Protein Alix Associates with CHMP4b, a Human Homologue of Yeast Snf7 That Is Involved in Multivesicular Body Sorting

2003 • 204 citations

Modulation of HIV-like particle assemblyin vitroby inositol phosphates

2001 • 203 citations

Rhabdoviruses and the Cellular Ubiquitin-Proteasome System: a Budding Interaction

2001 • 199 citations

Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome

2003 • 195 citations

Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.

1995 • 190 citations

Interaction of Endocytic Signals from the HIV-1 Envelope Glycoprotein Complex with Members of the Adaptor Medium Chain Family

1997 • 188 citations

The Mouse SKD1, a Homologue of Yeast Vps4p, Is Required for Normal Endosomal Trafficking and Morphology in Mammalian Cells

2000 • 186 citations

The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budding in MDCK cells

1997 • 185 citations

TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes

2001 • 182 citations

A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

2002 • 181 citations

Human immunodeficiency virus envelope protein determines the site of virus release in polarized epithelial cells.

1991 • 181 citations

HIV‐1 Egress is Gated Through Late Endosomal Membranes

2003 • 179 citations

Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity

2000 • 179 citations

Lipid Rafts and HIV Pathogenesis: Virion-Associated Cholesterol Is Required for Fusion and Infection of Susceptible Cells

2003 • 178 citations

Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions

2003 • 172 citations

Alix (ALG-2-interacting Protein X), a Protein Involved in Apoptosis, Binds to Endophilins and Induces Cytoplasmic Vacuolization

2002 • 168 citations

Differential Incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and Major Histocompatibility Complex Class I and II Molecules into Human Immunodeficiency Virus Type 1 Virions and Microvesicles: Implications for Viral Pathogenesis and Immune Regulation

2001 • 162 citations

Ubiquitin Is Covalently Attached to the p6 ^Gag Proteins of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus and to the p12 ^Gag Protein of Moloney Murine Leukemia Virus

1998 • 162 citations

Mutations altering the Moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle

1999 • 159 citations

Identification of Mammalian Vps24p as an Effector of Phosphatidylinositol 3,5-Bisphosphate-dependent Endosome Compartmentalization

2003 • 159 citations

Infectivity of Moloney Murine Leukemia Virus Defective in Late Assembly Events Is Restored by Late Assembly Domains of Other Retroviruses

2000 • 158 citations

Deubiquitination Step in the Endocytic Pathway of Yeast Plasma Membrane Proteins: Crucial Role of Doa4p Ubiquitin Isopeptidase

2001 • 157 citations

YPXL/I Is a Protein Interaction Motif Recognized by Aspergillus PalA and Its Human Homologue, AIP1/Alix

2003 • 154 citations

Retroviral Genomic RNAs Are Transported to the Plasma Membrane by Endosomal Vesicles

2003 • 152 citations

CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins

2001 • 149 citations

A Proline-Rich Motif (PPPY) in the Gag Polyprotein of Mason-Pfizer Monkey Virus Plays a Maturation-Independent Role in Virion Release

1998 • 148 citations

Deficient Peptide Loading and MHC Class II Endosomal Sorting in a Human Genetic Immunodeficiency Disease: the Chediak-Higashi Syndrome

1998 • 147 citations

Multivesicular Body Sorting: Ubiquitin Ligase Rsp5 Is Required for the Modification and Sorting of Carboxypeptidase S

2003 • 147 citations

Endosomal compartmentalization in three dimensions: Implications for membrane fusion

2003 • 144 citations

Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4

2002 • 144 citations

A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells

1995 • 142 citations

Ubiquitination of HIV-1 and MuLV Gag

2000 • 139 citations

Late Domain Function Identified in the Vesicular Stomatitis Virus M Protein by Use of Rhabdovirus-Retrovirus Chimeras

1999 • 135 citations

Virion-associated cholesterol is critical for the maintenance of HIV-1 structure and infectivity

2002 • 133 citations

PPPYEPTAP Motif Is the Late Domain of Human T-Cell Leukemia Virus Type 1 Gag and Mediates Its Functional Interaction with Cellular Proteins Nedd4 and Tsg101

2003 • 133 citations

Context-Dependent Effects of L Domains and Ubiquitination on Viral Budding

2004 • 133 citations

The Chediak-Higashi Protein Interacts with SNARE Complex and Signal Transduction Proteins

2002 • 130 citations

Human Immunodeficiency Virus Type 1 Assembly and Lipid Rafts: Pr55 ^gag Associates with Membrane Domains That Are Largely Resistant to Brij98 but Sensitive to Triton X-100

2003 • 129 citations

Possible Involvement of a Novel STAM-associated Molecule “AMSH” in Intracellular Signal Transduction Mediated by Cytokines

1999 • 128 citations

A dominant negative form of the AAA ATPase SKD1/VPS4 impairs membrane trafficking out of endosomal/lysosomal compartments: class Evpsphenotype in mammalian cells

2002 • 126 citations

The Mason-Pfizer Monkey Virus PPPY and PSAP Motifs Both Contribute to Virus Release

2003 • 126 citations

The HIV-1 assembly machine

2001 • 125 citations

Structural determinants for the binding of ubiquitin-like domains to the proteasome

2003 • 123 citations

Structural Insights into Endosomal Sorting Complex Required for Transport (ESCRT-I) Recognition of Ubiquitinated Proteins

2004 • 122 citations

Equine Infectious Anemia Virus Gag Polyprotein Late Domain Specifically Recruits Cellular AP-2 Adapter Protein Complexes during Virion Assembly

1998 • 118 citations

M‐PMV Capsid Transport Is Mediated by Env/Gag Interactions at the Pericentriolar Recycling Endosome

2003 • 108 citations

Hrs and Endocytic Sorting of Ubiquitinated Membrane Proteins.

2002 • 104 citations

Ubiquitin in retrovirus assembly: Actor or bystander?

2000 • 102 citations

Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TGS101 and VPS4A

2004 • 102 citations

Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport inSaccharomyces cerevisiae

2003 • 99 citations

Mammalian Cells Express Two VPS4 Proteins Both of Which are Involved in Intracellular Protein Trafficking

2001 • 95 citations

Permease Recycling and Ubiquitination Status Reveal a Particular Role for Bro1 in the Multivesicular Body Pathway

2003 • 92 citations

Endocytosis in Viral Replication

2000 • 91 citations

NSF and p97/VCP: similar at first, different at last

2003 • 89 citations

Independent Segregation of Human Immunodeficiency Virus Type 1 Gag Protein Complexes and Lipid Rafts

2003 • 87 citations

Ubiquitin in avian leukosis virus particles

1990 • 85 citations

The Rsp5 Ubiquitin Ligase Binds to and Ubiquitinates Members of the Yeast CIN85-Endophilin Complex, Sla1-Rvs167

2004 • 85 citations

Late Assembly Domain Function Can Exhibit Context Dependence and Involves Ubiquitin Residues Implicated in Endocytosis

2002 • 81 citations

In Vivo Attenuation of Simian Immunodeficiency Virus by Disruption of a Tyrosine-Dependent Sorting Signal in the Envelope Glycoprotein Cytoplasmic Tail

2001 • 76 citations

Characterization of Vta1p, a Class E Vps Protein in Saccharomyces cerevisiae

2004 • 72 citations

Functional Replacement and Positional Dependence of Homologous and Heterologous L Domains in Equine Infectious Anemia Virus Replication

2002 • 66 citations

Budding of Equine Infectious Anemia Virus Is Insensitive to Proteasome Inhibitors

2002 • 65 citations

The PPPY Motif of Human T-Cell Leukemia Virus Type 1 Gag Protein Is Required Early in the Budding Process

2002 • 65 citations

Cloning and Characterization of ELL-associated Proteins EAP45 and EAP20

2001 • 54 citations

Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production

2003 • 50 citations

The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment

1997 • 48 citations

Basic Residues of the Helix Six Domain of Influenza Virus M1 Involved in Nuclear Translocation of M1 Can Be Replaced by PTAP and YPDL Late Assembly Domain Motifs

2003 • 46 citations

Analysis of Bovine Leukemia Virus Gag Membrane Targeting and Late Domain Function

2002 • 42 citations

Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent

2002 • 7 citations