The E3 Ubiquitin Ligase AIP4 Mediates Ubiquitination and Sorting of the G Protein-Coupled Receptor CXCR4

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

Regulation of Receptor Fate by Ubiquitination of Activated β ₂ -Adrenergic Receptor and β-Arrestin

2001 • 807 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

1998 • 746 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

1999 • 663 citations

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

2002 • 629 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

Cbl: many adaptations to regulate protein tyrosine kinases

2001 • 621 citations

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins

2002 • 519 citations

Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal Sorting

2001 • 456 citations

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

2003 • 448 citations

Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

2002 • 431 citations

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

2002 • 417 citations

Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p

1997 • 412 citations

Hrs recruits clathrin to early endosomes

2001 • 374 citations

The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting

2002 • 345 citations

Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes

2002 • 338 citations

Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

2001 • 324 citations

STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes

2003 • 306 citations

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes

2001 • 302 citations

The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways

2000 • 299 citations

Regulation of Human Chemokine Receptors CXCR4

1997 • 290 citations

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

2002 • 264 citations

100-kD coated vesicle proteins: molecular heterogeneity and intracellular distribution studied with monoclonal antibodies

1987 • 234 citations

A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP

2000 • 225 citations

The ins and outs of G protein-coupled receptor trafficking

2003 • 210 citations

Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

1999 • 199 citations

The Mouse SKD1, a Homologue of Yeast Vps4p, Is Required for Normal Endosomal Trafficking and Morphology in Mammalian Cells

2000 • 186 citations

TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes

2001 • 182 citations

Ubiquitination of the yeast a-factor receptor.

1996 • 172 citations

Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases

2000 • 171 citations

Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets

1997 • 163 citations

Ubiquitin Sorts Proteins into the Intralumenal Degradative Compartment of the Late‐Endosome/Vacuole

2001 • 151 citations

Multiple Roles for Rsp5p-dependent Ubiquitination at the Internalization Step of Endocytosis

2001 • 147 citations

Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4

2002 • 144 citations

Domains of the Rsp5 Ubiquitin-Protein Ligase Required for Receptor-mediated and Fluid-Phase Endocytosis

2001 • 135 citations

Syntaxin-16, a putative Golgi t-SNARE

1998 • 119 citations

Localization of the Rsp5p Ubiquitin-Protein Ligase at Multiple Sites within the Endocytic Pathway

2001 • 92 citations

Interaction between Two Ubiquitin-Protein Isopeptide Ligases of Different Classes, CBLC and AIP4/ITCH

2002 • 84 citations

Clathrin assembly protein AP-2 induces aggregation of membrane vesicles: a possible role for AP-2 in endosome formation.

1992 • 46 citations

Regulation of G protein-coupled receptor function and expression

2000 • 26 citations