Permease Recycling and Ubiquitination Status Reveal a Particular Role for Bro1 in the Multivesicular Body Pathway

Functional organization of the yeast proteome by systematic analysis of protein complexes

2002 • 4,751 citations

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

2001 • 1,492 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast.

1995 • 1,352 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression

1994 • 968 citations

Escrt-III

2002 • 854 citations

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

1992 • 832 citations

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

1998 • 746 citations

Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

1998 • 652 citations

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

2002 • 629 citations

Nitrogen regulation in Saccharomyces cerevisiae

2002 • 612 citations

Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors

2002 • 571 citations

A family of low and high copy replicative, integrative and single‐stranded S. cerevisiae/E. coli shuttle vectors

1991 • 533 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

2002 • 468 citations

Homotypic vacuolar fusion mediated by t- and v-SNAREs

1997 • 457 citations

Multiplicity of the amino acid permeases in Saccharomyces cerevisiae

1966 • 427 citations

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

2002 • 417 citations

Fab1p Is Essential for PtdIns(3)P 5-Kinase Activity and the Maintenance of Vacuolar Size and Membrane Homeostasis

1998 • 416 citations

Multiplicity of the amino acid permeases in Saccharomyces cerevisiae

1967 • 403 citations

PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.

1986 • 400 citations

VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.

1995 • 393 citations

end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

1993 • 380 citations

Specific Retrieval of the Exocytic SNARE Snc1p from Early Yeast Endosomes

2000 • 363 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

A Multispecificity Syntaxin Homologue, Vam3p, Essential for Autophagic and Biosynthetic Protein Transport to the Vacuole

1997 • 349 citations

The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting

2002 • 345 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

2001 • 324 citations

Genomic Screen for Vacuolar Protein Sorting Genes inSaccharomyces cerevisiae

2002 • 310 citations

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1998 • 308 citations

The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways

2000 • 299 citations

GAP1, the general amino acid permease gene of Saccharomyces cerevisiae

1990 • 296 citations

The PEP4 Gene Encodes an Aspartyl Protease Implicated in the Posttranslational Regulation of Saccharomyces cerevisiae Vacuolar Hydrolases

1986 • 292 citations

Vps52p, Vps53p, and Vps54p Form a Novel Multisubunit Complex Required for Protein Sorting at the Yeast Late Golgi

2000 • 288 citations

The Doa4 Deubiquitinating Enzyme Is Required for Ubiquitin Homeostasis in Yeast

1999 • 285 citations

Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast.

1996 • 284 citations

Vacuole Biogenesis in Saccharomyces cerevisiae : Protein Transport Pathways to the Yeast Vacuole

1998 • 281 citations

Components of a Ubiquitin Ligase Complex Specify Polyubiquitination and Intracellular Trafficking of the General Amino Acid Permease

2001 • 270 citations

Mechanisms of enveloped RNA virus budding

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Mutations Affecting the Repressibility of Arginine Biosynthetic Enzymes in Sacchromyces cerevisiae

1970 • 245 citations

Cycling of the integral membrane glycoprotein, LEP100, between plasma membrane and lysosomes: Kinetic and morphological analysis

1987 • 244 citations

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors

1993 • 239 citations

Cloning of AIP1, a Novel Protein That Associates with the Apoptosis-linked Gene ALG-2 in a Ca2+-dependent Reaction

1999 • 234 citations

Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein

1999 • 234 citations

Ubiquitin Is Required for Sorting to the Vacuole of the Yeast General Amino Acid Permease, Gap1

2001 • 231 citations

Nitrogen-regulated Ubiquitination of the Gap1 Permease ofSaccharomyces cerevisiae

1998 • 211 citations

Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae

2003 • 207 citations

An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes

2001 • 201 citations

Vam7p, a SNAP-25-Like Molecule, and Vam3p, a Syntaxin Homolog, Function Together in Yeast Vacuolar Protein Trafficking

1998 • 199 citations

CIN85/CMS family of adaptor molecules

2002 • 196 citations

Physiological Regulation of Membrane Protein Sorting Late in the Secretory Pathway of Saccharomyces cerevisiae

1997 • 191 citations

Regulation of Fab1 Phosphatidylinositol 3-Phosphate 5-Kinase Pathway by Vac7 Protein and Fig4, a Polyphosphoinositide Phosphatase Family Member

2002 • 169 citations

Alix (ALG-2-interacting Protein X), a Protein Involved in Apoptosis, Binds to Endophilins and Induces Cytoplasmic Vacuolization

2002 • 168 citations

The Npr1 Kinase Controls Biosynthetic and Endocytic Sorting of the Yeast Gap1 Permease

2001 • 162 citations

YPXL/I Is a Protein Interaction Motif Recognized by Aspergillus PalA and Its Human Homologue, AIP1/Alix

2003 • 154 citations

Ubiquitin Sorts Proteins into the Intralumenal Degradative Compartment of the Late‐Endosome/Vacuole

2001 • 151 citations

NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains

1999 • 144 citations

A cis-dominant regulatory mutation linked to the argB-argC gene cluster in Saccharomyces cerevisiae

1980 • 138 citations

PROTEIN AND LIPID REQUIREMENTS FOR ENDOCYTOSIS

2000 • 131 citations

Vps51p Links the VFT Complex to the SNARE Tlg1p

2002 • 130 citations

Retrograde Traffic Out of the Yeast Vacuole to the TGN Occurs via the Prevacuolar/Endosomal Compartment

1998 • 126 citations

Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion

1998 • 117 citations

The Syntaxin Tlg1p Mediates Trafficking of Chitin Synthase III to Polarized Growth Sites in Yeast

1998 • 117 citations

Inactivation‐Reactivation Process and Repression of Permease Formation Regulate Several Ammonia‐Sensitive Permeases in the Yeast Saccharomyces cerevisiae

1983 • 103 citations

TheSaccharomyces cerevisiae NPR1 gene required for the activity of ammonia-sensitive amino acid permeases encodes a protein kinase homologue

1990 • 98 citations

Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomyces cerevisiae

2002 • 92 citations

Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p

1996 • 87 citations

Pep12p is a Multifunctional Yeast Syntaxin that Controls Entry of Biosynthetic, Endocytic and Retrograde Traffic into the Prevacuolar Compartment

2000 • 86 citations

Suppressors of ssy1 and ptr3 Null Mutations Define Novel Amino Acid Sensor-Independent Genes in Saccharomyces cerevisiae

2001 • 77 citations

Uptake of the ATP-Binding Cassette (ABC) Transporter Ste6 into the Yeast Vacuole Is Blocked in the doa4 Mutant

2001 • 74 citations

BRO1, a Novel Gene That Interacts with Components of the Pkc1p–Mitogen-Activated Protein Kinase Pathway in Saccharomyces cerevisiae

1996 • 67 citations

Recycling of the Yeast a-Factor Receptor

2000 • 64 citations

Yeast Npi3/Bro1 is involved in ubiquitin‐dependent control of permease trafficking

2002 • 61 citations

Membrane curvature: a case of endofeelin’…

2002 • 60 citations

A Role for Tlg1p in the Transport of Proteins within the Golgi Apparatus ofSaccharomyces cerevisiae

1999 • 56 citations

Casein kinase I controls a late step in the endocytic trafficking of yeast uracil permease

2002 • 46 citations

Cycling of Two Endogenous Lysosomal Membrane Proteins, Lamp-2 and Acid Phosphatase, between the Cell Surface and Lysosomes in Cultured Rat Hepatocytes

1993 • 33 citations