The Biogenesis and Functions of Exosomes

Immunobiology of Dendritic Cells

2000 • 6,653 citations

B lymphocytes secrete antigen-presenting vesicles.

1996 • 3,198 citations

Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin

2000 • 2,603 citations

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes).

1987 • 2,537 citations

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

1998 • 2,078 citations

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

1983 • 1,757 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

2001 • 1,492 citations

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

1999 • 1,379 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 Budding

2001 • 1,351 citations

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

1998 • 1,153 citations

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device

2000 • 1,033 citations

Molecular Characterization of Dendritic Cell-Derived Exosomes

1999 • 1,005 citations

The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases

1997 • 939 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

Intestinal epithelial cells secrete exosome–like vesicles

2001 • 664 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

2000 • 658 citations

Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

1998 • 652 citations

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

1999 • 628 citations

TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex

2002 • 624 citations

Roles of lipid rafts in membrane transport

2001 • 623 citations

Tetraspanins

2001 • 554 citations

Three ways to make a vesicle

2000 • 547 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos

1999 • 527 citations

Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry

2001 • 522 citations

Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells

1997 • 520 citations

Dendritic cells as a tool to induce anergic and regulatory T cells

2001 • 478 citations

The gamete fusion process is defective in eggs of Cd9-deficient mice

2000 • 476 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Transport-vesicle targeting: tethers before SNAREs

1999 • 451 citations

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

2000 • 430 citations

Argosomes

2001 • 413 citations

Accumulation of Major Histocompatibility Complex Class II Molecules in Mast Cell Secretory Granules and Their Release upon Degranulation

1997 • 402 citations

Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding.

1984 • 397 citations

An Electron Microscope Study of the Rat Ovum

1959 • 386 citations

Specific tetraspanin functions

2001 • 380 citations

Endocytic Sorting of Lipid Analogues Differing Solely in the Chemistry of Their Hydrophobic Tails

1999 • 378 citations

Hrs recruits clathrin to early endosomes

2001 • 374 citations

CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA‐DR and VLA integrins

1996 • 371 citations

GOLGI APPARATUS AND LYSOSOMES.

1964 • 367 citations

Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes

2002 • 338 citations

Mast Cell-Dependent B and T Lymphocyte Activation Is Mediated by the Secretion of Immunologically Active Exosomes

2001 • 326 citations

Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

2001 • 324 citations

Late endosomes derive from early endosomes by maturation

1991 • 311 citations

Evaluation of Prototype Transmembrane 4 Superfamily Protein Complexes and Their Relation to Lipid Rafts

2001 • 300 citations

Synaptotagmin VII Regulates Ca2+-Dependent Exocytosis of Lysosomes in Fibroblasts

2000 • 298 citations

"Tolerosomes" are produced by intestinal epithelial cells

2001 • 291 citations

Recycling MHC class I molecules and endosomal peptide loading

1999 • 290 citations

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

2001 • 285 citations

Generation of Monoclonal Antibodies to Integrin-associated Proteins

1997 • 282 citations

Immunoelectron Microscopic Localization of Cholesterol Using Biotinylated and Non-cytolytic Perfringolysin O

2002 • 282 citations

MHC Class I–Restricted CTL Responses to Exogenous Antigens

1996 • 265 citations

A Novel Link between Integrins, Transmembrane-4 Superfamily Proteins (CD63 and CD81), and Phosphatidylinositol 4-Kinase

1997 • 264 citations

Shrinking patches and slippery rafts: scales of domains in the plasma membrane

2001 • 251 citations

Human VPS34 is required for internal vesicle formation within multivesicular endosomes

2001 • 242 citations

Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

1997 • 233 citations

Implications of lipid microdomains for membrane curvature, budding and fission

2001 • 233 citations

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

1999 • 232 citations

Role of Transmembrane 4 Superfamily (Tm4sf) Proteins Cd9 and Cd81 in Muscle Cell Fusion and Myotube Maintenance

1999 • 231 citations

Fusion of Lysosomes with Late Endosomes Produces a Hybrid Organelle of Intermediate Density and Is NSF Dependent

1998 • 216 citations

Tetraspan microdomains distinct from lipid rafts enrich select peptide–MHC class II complexes

2001 • 212 citations

Sorting in the endosomal system in yeast and animal cells

2000 • 211 citations

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

1996 • 210 citations

Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor

2001 • 190 citations

TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes

2001 • 182 citations

The role of endosomes and lysosomes in MHC class II functioning

1998 • 179 citations

Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation

1997 • 178 citations

The Human Cytomegalovirus US28 Protein Is Located in Endocytic Vesicles and Undergoes Constitutive Endocytosis and Recycling

2001 • 178 citations

Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins

1994 • 177 citations

Exosomes released during reticulocyte maturation bind to fibronectin via integrin α4β1

2000 • 174 citations

Novel pathways of antigen presentation for the maintenance of memory

1991 • 173 citations

Regulated Secretion from Hemopoietic Cells

1999 • 166 citations

The Tetraspan Protein CD82 Is a Resident of MHC Class II Compartments Where It Associates with HLA-DR, -DM, and -DO Molecules

1998 • 165 citations

Follicular dendritic cells: beyond the necessity of T-cell help

2001 • 160 citations

Multivesicular bodies in HEp-2 cells are maturing endosomes.

1993 • 154 citations

Decay-Accelerating Factor (CD55) and Membrane Inhibitor of Reactive Lysis (CD59) Are Released Within Exosomes During In Vitro Maturation of Reticulocytes

1998 • 138 citations

Designer dendritic cells for tolerance induction: guided not misguided missiles

2001 • 132 citations

Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes.

1995 • 130 citations

Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.

1995 • 115 citations

VESICLE FUSION AND FORMATION AT THE SURFACE OF PINOCYTIC VACUOLES IN MACROPHAGES

1968 • 114 citations

Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion.

1999 • 111 citations

Triple check for antigen specificity of B cells during germinal centre reactions

1997 • 111 citations

A new model for lethal hit delivery by cytotoxic T lymphocytes

1990 • 96 citations

Murine CD9 Is the Receptor for Pregnancy-specific Glycoprotein 17

2002 • 92 citations

Endocytosis in Viral Replication

2000 • 91 citations

Morphogen Gradient Formation and Vesicular Trafficking

2002 • 88 citations

CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus

1997 • 87 citations

MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions

1999 • 83 citations

Receptor clustering and transmembrane signaling in T cells

2001 • 80 citations

Prostasomes: Current concepts

2000 • 79 citations

Characteristics of the Interaction between Hsc70 and the Transferrin Receptor in Exosomes Released during Reticulocyte Maturation

2001 • 65 citations

Hrs-2 Regulates Receptor-mediated Endocytosis via Interactions with Eps15

2000 • 62 citations

Dendritic cells: their significance in health and disease

2001 • 58 citations

The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes.

1997 • 55 citations

Transmembrane 4 superfamily protein CD151 (PETA-3) associates with β1 and αIIbβ3 integrins in haemopoietic cell lines and modulates cell‒cell adhesion

1999 • 30 citations

AIDS and AIDS-related infections: Current strategies for Prevention and therapy

1990 • 14 citations

Deleted Work

1955 • 0 citations