Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions

Lipid rafts and signal transduction

2000 • 6,079 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

1995 • 1,158 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

1987 • 729 citations

Plasma membrane rafts play a critical role in HIV-1 assembly and release

2001 • 675 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

A Conserved Tryptophan-Rich Motif in the Membrane-Proximal Region of the Human Immunodeficiency Virus Type 1 gp41 Ectodomain Is Important for Env-Mediated Fusion and Virus Infectivity

1999 • 415 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

1995 • 385 citations

Membrane raft microdomains mediate lateral assemblies required for HIV‐1 infection

2000 • 352 citations

Lipid Rafts and HIV Pathogenesis: Host Membrane Cholesterol Is Required for Infection by HIV Type 1

2001 • 348 citations

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

1999 • 330 citations

HIV-1 Auxiliary Proteins: Making Connections in a Dying Cell

1998 • 328 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

1994 • 305 citations

Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide

2001 • 303 citations

Plasma membrane caveolae mediate the efflux of cellular free cholesterol

1995 • 273 citations

Nef Triggers a Transcriptional Program in T Cells Imitating Single-Signal T Cell Activation and Inducing HIV Virulence Mediators

2001 • 269 citations

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

2000 • 269 citations

Activation of Vav by Nef Induces Cytoskeletal Rearrangements and Downstream Effector Functions

1999 • 234 citations

Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

1990 • 221 citations

CXCR4 Function Requires Membrane Cholesterol: Implications for HIV Infection

2002 • 203 citations

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1999 • 180 citations

Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization

2002 • 166 citations

Lipid Rafts and Pseudotyping

2001 • 164 citations

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

2002 • 159 citations

Nef increases infectivity of HIV via lipid rafts

2001 • 150 citations

Caveolins and Cellular Cholesterol Balance

2000 • 145 citations

Human Immunodeficiency Virus Type 1 Nef Functions at the Level of Virus Entry by Enhancing Cytoplasmic Delivery of Virions

2001 • 142 citations

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry

1995 • 140 citations

Virion-associated cholesterol is critical for the maintenance of HIV-1 structure and infectivity

2002 • 133 citations

Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion

1990 • 124 citations

Identification of a conserved domain of the HIV-1 transmembrane protein gp41 which interacts with cholesteryl groups

2002 • 118 citations

The Nef protein of primate lentiviruses

1999 • 83 citations

Cyclic Adenosine 3′,5′-Monophosphate(cAMP)/cAMP-Responsive Element Modulator (CREM)-Dependent Regulation of Cholesterogenic Lanosterol 14α-Demethylase (CYP51) in Spermatids

1999 • 73 citations

Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant.

1987 • 71 citations

Sterol Efflux to Apolipoprotein A-I Originates from Caveolin-Rich Microdomains and Potentiates PDGF-Dependent Protein Kinase Activity

2002 • 54 citations

HIV-1 Nef and host cell protein kinases

1997 • 48 citations

Sterol-mediated regulation of mevalonic acid synthesis. Accumulation of 4-carboxysterols as the predominant sterols synthesized in a Chinese hamster ovary cell cholesterol auxotroph (mutant 215).

1990 • 23 citations