Interstitial Fibrosis and Growth Factors

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

Natural History and Treated Course of Usual and Desquamative Interstitial Pneumonia

1978 • 802 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor

1996 • 754 citations

The Lung: Scientific Foundations

1997 • 731 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

1995 • 364 citations

Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.

1996 • 343 citations

Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure.

1993 • 329 citations

Pathobiology of pulmonary fibrosis

1990 • 326 citations

Lung Cytokine Production in Bleomycin-Induced Pulmonary Fibrosis

1992 • 321 citations

Induction of Apoptosis and Pulmonary Fibrosis in Mice in Response to Ligation of Fas Antigen

1997 • 289 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

Surgical Pathology of Non-Neoplastic Lung Disease.

1983 • 253 citations

Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis.

1997 • 243 citations

Crystal structure of human platelet-derived growth factor BB.

1992 • 232 citations

Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells.

1988 • 214 citations

Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice.

1988 • 199 citations

Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis.

1993 • 188 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

Expression of TNF and the Necessity of TNF Receptors in Bleomycin-Induced Lung Injury in Mice

1998 • 184 citations

Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.

1990 • 179 citations

Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level

1999 • 177 citations

Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation.

1996 • 175 citations

PDGF-Receptor Tyrosine Kinase Blocker AG1295 Selectively Attenuates Smooth Muscle Cell Growth In Vitro and Reduces Neointimal Formation After Balloon Angioplasty in Swine

1998 • 171 citations

TNF-alpha-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis.

1997 • 170 citations

Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis

1997 • 169 citations

Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

1999 • 169 citations

Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica.

1996 • 162 citations

Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor.

1992 • 156 citations

Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma.

1995 • 153 citations

Plasmin regulates the activation of cell-associated latent TGF-beta 1 secreted by rat alveolar macrophages after in vivo bleomycin injury.

1996 • 149 citations

Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.

1995 • 146 citations

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

1999 • 144 citations

A histologically distinctive interstitial pneumonia induced by overexpression of the interleukin 6, transforming growth factor beta 1, or platelet-derived growth factor B gene.

1995 • 140 citations

Emphysematous Lesions, Inflammation, and Fibrosis in the Lungs of Transgenic Mice Overexpressing Platelet-Derived Growth Factor

1999 • 132 citations

Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis.

1998 • 131 citations

Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis.

1993 • 125 citations

Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.

1997 • 124 citations

Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells.

1992 • 110 citations

Production of platelet-derived growth factorlike protein by rat mesangial cells in culture.

1987 • 110 citations

Contractile Cells in Normal and Fibrotic Lung

1990 • 107 citations

Platelets play an important role in TNF-induced microvascular endothelial cell pathology.

1997 • 104 citations

Differential Proliferation of Rat Lung Fibroblasts Induced by the Platelet-derived Growth Factor-AA, -AB, and -BB Isoforms Secreted by Rat Alveolar Macrophages

1991 • 103 citations

Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos.

1988 • 99 citations

Transforming growth factor-beta (TGF-beta) in silicosis.

1996 • 99 citations

Acute lung injury. Pathogenesis of intraalveolar fibrosis.

1991 • 98 citations

Adenovirus-Mediated Blockade Of Tumor Necrosis Factor In Mice Protects Against Endotoxic Shock Yet Impairs Pulmonary Host Defense

1995 • 98 citations

Control of Collagen Deposition in Mammalian Lung

1995 • 97 citations

Rapid Activation of PDGF-A and -B Expression at Sites of Lung Injury in Asbestos-exposed Rats

1997 • 92 citations

Platelet‐derived growth factor: Morphologic and biochemical studies of binding, internalization, and degradation

1984 • 88 citations

Fibrotic Reactions in the Lung: The Activation of the Lung Fibroblast

1986 • 88 citations

Immunohistochemical localization of transforming growth factor-beta 1 in the nonnecrotizing granulomas of pulmonary sarcoidosis.

1994 • 87 citations

Increased expression of the interleukin-10 gene by alveolar macrophages in interstitial lung disease

1997 • 81 citations

Inhibition of tumor necrosis factor and subsequent endotoxin shock by pirfenidone

1998 • 80 citations

Antiinflammatory and Antifibrotic Properties of Colchicine: Implications for Idiopathic Pulmonary Fibrosis

1997 • 79 citations

Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo.

1996 • 74 citations

The role of IL-5 in bleomycin-induced pulmonary fibrosis

1998 • 69 citations

Exacerbation of murine Pneumocystis carinii infection by adenoviral-mediated gene transfer of a TNF inhibitor.

1997 • 69 citations

Mineral Dusts Directly Induce Epithelial and Interstitial Fibrogenic Mediators and Matrix Components in the Airway Wall

1998 • 68 citations

Chrysotile asbestos upregulates gene expression and production of alpha-receptors for platelet-derived growth factor (PDGF-AA) on rat lung fibroblasts.

1993 • 68 citations

Idiopathic Pulmonary Fibrosis

1987 • 67 citations

Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice.

1997 • 64 citations

Interstitial pulmonary macrophages produce platelet-derived growth factor that stimulates rat lung fibroblast proliferation in vitro

1992 • 56 citations

Mesenchymal cells isolated after acute lung injury manifest an enhanced proliferative phenotype.

1992 • 55 citations

Increased susceptibility to silicosis and TNF-alpha production in C57BL/6J mice.

1995 • 52 citations

Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts

1989 • 42 citations

Environmental & occupational medicine

1998 • 42 citations

Cytokine-binding proteins in the lung

1995 • 42 citations

Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis. A compartmental analysis.

1995 • 39 citations

Platelet-derived growth factor (PDGF) receptor alpha-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-beta can be mitogenic through PDGF A-chain-dependent and -independent pathways.

1994 • 38 citations

Increased tumor necrosis factor-alpha (TNF-alpha) gene expression in parainfluenza type 1 (Sendai) virus-induced bronchiolar fibrosis.

1998 • 31 citations

Cell cycle regulation of human diploid fibroblasts: Possible mechanisms of platelet‐derived growth factor

1989 • 26 citations

SIMULTANEOUS OCCURRENCE OF GREY PLATELET SYNDROME AND IDIOPATHIC PULMONARY FIBROSIS: A ROLE FOR ABNORMAL MEGAKARYOCYTES IN THE PATHOGENESIS OF PULMONARY FIBROSIS?

1990 • 26 citations

Lung cell toxicity experimentally induced by a mixed dust from Mexicali, Baja California, Mexico

1991 • 25 citations

Expression of transforming growth factor-beta receptors during hyperoxia-induced lung injury and repair

1997 • 23 citations

Tumor necrosis factor stimulates gelatinase and collagenase production by granulation tissue in culture

1987 • 22 citations

Immunohistochemical Localization of Transforming Growth Factor Beta Isoforms in Asbestos-Related Diseases

1997 • 16 citations

Effect of the different dimeric forms of the platelet‐derived growth factor on cellular responses in mouse Swiss 3T3 fibroblasts

1989 • 14 citations

Tumor Necrosis Factor Alpha Gene Expression in Human Monocytic THP-1 Cells Exposed to Beryllium

1996 • 12 citations

Chrysotile Asbestos Induces PDGF-A Chain-Dependent Proliferation in Human and Rat Lung Fibroblasts In Vitro

1996 • 10 citations

[Pulmonary interstitial pneumonia in association with Hermansky-Pudlak syndrome].

1991 • 10 citations

Role of tumor necrosis factor-alpha in regulating fibrotic lung repair.

1998 • 10 citations

Inhibition of obliterative bronchiolitis by platelet-derived growth factor receptor protein-tyrosine kinase inhibitor

1999 • 9 citations

The Physiology of Interstitial Lung Disease

2019 • 8 citations

AMIODARONE-INDUCED PULMONARY TOXICITY IN FISCHER RATS: RELEASE OF TUMOR NECROSIS FACTOR ALPHA AND TRANSFORMING GROWTH FACTOR BETA BY PULMONARY ALVEOLAR MACROPHAGES

1997 • 6 citations

Connective Tissue Disease

2018 • 5 citations

[Role of TGF-beta and PDGF on the pathogenesis of pulmonary fibrosis--analysis by in vivo gene transfer].

1996 • 5 citations

Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the "slow" and "fast" conformations of alpha 2-macroglobulin.

1992 • 4 citations

Modulation of TNF-alpha secretions by alveolar macrophages and blood monocytes after soot-particle or asbestos fibre exposure.

1996 • 4 citations

Pathology of asbestos related diseases

1993 • 4 citations