Fibrotic Reactions in the Lung: The Activation of the Lung Fibroblast

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

The Biosynthesis of Collagen and Its Disorders

1979 • 1,067 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

A significant part of macrophage-derived growth factor consists of at least two forms of PDGF

1985 • 719 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Interstitial Lung Diseases of Unknown Cause

1984 • 696 citations

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

1977 • 695 citations

A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.

1976 • 579 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.

1981 • 506 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis

1978 • 472 citations

Interstitial Lung Diseases of Unknown Cause

1984 • 472 citations

The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

1974 • 469 citations

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

1981 • 427 citations

Radioimmunoassay for type III procollagen peptide and its application to human liver disease

1979 • 396 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Developmentally regulated production of platelet-derived growth factor-like molecules

1984 • 368 citations

Microinjected c- myc as a Competence Factor

1985 • 361 citations

Lymphocyte-Mediated Activation of Fibroblast Proliferation and Collagen Production

1978 • 358 citations

"CONTRACTILE INTERSTITIAL CELLS" IN PULMONARY ALVEOLAR SEPTA: A POSSIBLE REGULATOR OF VENTILATION/PERFUSION RATIO?

1974 • 345 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Lymphokine stimulation of collagen accumulation.

1976 • 322 citations

Epidermal Cell Production of Thymocyte Activating Factor (ETAF)

1982 • 319 citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

1982 • 318 citations

Human Alveolar Macrophage Growth Factor for Fibroblasts

1982 • 301 citations

c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors

1985 • 300 citations

Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis

1978 • 292 citations

Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

1980 • 282 citations

Chemotactic activity of platelet alpha granule proteins for fibroblasts.

1983 • 275 citations

Collagen polymorphism in idiopathic chronic pulmonary fibrosis.

1976 • 264 citations

Endogenous pyrogens made by rabbit peritoneal exudate cells are identical with lymphocyte-activating factors made by rabbit alveolar macrophages.

1980 • 260 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Inhibiting effect of procollagen peptides on collagen biosynthesis in fibroblast cultures.

1979 • 255 citations

The molecular biology of platelet-derived growth factor

1983 • 252 citations

Interaction of platelet-derived growth factor with its fibroblast receptor. Demonstration of ligand degradation and receptor modulation.

1982 • 239 citations

Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis.

1979 • 237 citations

Retroviral transforming genes in normal cells?

1983 • 225 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

Ability of human leukocytic pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation

1981 • 217 citations

Human large granular lymphocytes are potent producers of interleukin-1

1984 • 212 citations

Advances in Inflammation Research

1983 • 211 citations

Extracellular matrix in normal and fibrotic human lungs.

1985 • 200 citations

Fibroblast heterogeneity and prostaglandin regulation of subpopulations

1977 • 181 citations

Platelet-derived growth factor. Structure, function, and roles in normal and transformed cells.

1984 • 178 citations

Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen.

1980 • 178 citations

The pathogenesis and structure of paraquat‐induced pulmonary fibrosis in rats

1974 • 164 citations

Regulation of the production of secretory proteins: Intracellular degradation of newly synthesized “defective” collagen

1980 • 164 citations

The Proteins of Oncogenes

1984 • 163 citations

Control of collagen production by human diploid lung fibroblasts.

1980 • 158 citations

Characterization by electrophoresis of epidermal growth factor stimulated phosphorylation using A-431 membranes

1980 • 153 citations

The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts.

1982 • 147 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1955 • 145 citations

Evidence That the v- sis Gene Product Transforms by Interaction with the Receptor for Platelet-Derived Growth Factor

1985 • 138 citations

Bleomycin-induced Pulmonary Fibrosis in Rats: Biochemical Demonstration of Increased Rate of Collagen Synthesis^1,2

1980 • 138 citations

Immunohistochemical study of collagen types in human foetal lung and fibrotic lung disease.

1981 • 136 citations

Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: pathology and stereology.

1978 • 132 citations

Profiles of steady state levels of messenger RNAs coding for type I procollagen, elastin, and fibronectin in hamster lungs undergoing bleomycin-induced interstitial pulmonary fibrosis.

1985 • 131 citations

Pathogenic mechanisms in pulmonary fibrosis: collagen-induced migration inhibition factor production and cytotoxicity mediated by lymphocytes.

1976 • 131 citations

Rat lung fibroblast collagen metabolism in bleomycin-induced pulmonary fibrosis.

1985 • 126 citations

Platelet-derived growth factor-modulated proteins: constitutive synthesis by a transformed cell line.

1981 • 125 citations

ONCOGENES

1984 • 123 citations

Increased elastin and collagen content in the lungs of hamsters receiving an intratracheal injection of bleomycin.

1978 • 122 citations

Modulation of the sis Gene Transcript During Endothelial Cell Differentiation in Vitro

1985 • 117 citations

Association in normal human fibroblasts of elevated levels of adenosine 3‘:5‘-monophosphate with a selective decrease in collagen production.

1978 • 116 citations

Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor.

1984 • 113 citations

Stimulation of DNA Synthesis in Quiescent Cultured Cells: Exogenous Agents, Internal Signals, and Early Events

1980 • 113 citations

Effect of interleukin 1 on human thymocytes and purified human T cells.

1981 • 112 citations

Lavage type III procollagen N-terminal peptides in human pulmonary fibrosis and sarcoidosis.

1983 • 111 citations

Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process.

1985 • 110 citations

Endothelial injury and repair in radiation-induced pulmonary fibrosis.

1983 • 105 citations

Modulation of fibroblast growth by a lymphokine of human T cell continuous T cell line origin.

1983 • 103 citations

Collagen synthesis by monkey arterial smooth muscle cells during proliferation and quiescence in culture

1977 • 100 citations

Protein Metabolism during Bleomycin-induced Pulmonary Fibrosis in Rabbits

1983 • 100 citations

Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts

1978 • 98 citations

Glycolysis of quiescent cultures of 3T3 cells. Addition of serum, epidermal growth factor, and insulin increases the activity of phosphofructokinase in a protein synthesis-independent manner.

1978 • 97 citations

Epidermal growth factor (EGF) is required only during the traverse of early G1 in PDGF stimulated density-arrested BALB/c-3T3 cells

1983 • 94 citations

Collagen biosynthesis in bleomycin-induced pulmonary fibrosis in hamsters.

1980 • 90 citations

STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES

1958 • 88 citations

Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Changes in prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase activities

1976 • 79 citations

Biochemical and immunochemical study of lysyl oxidase in experimental hepatic fibrosis in the rat.

1978 • 79 citations

Similar action of platelet‐derived growth factor and epidermal growth factor in the prereplicative phase of human fibroblasts suggests a common intracellular pathway

1985 • 79 citations

Failure of mechanical properties to parallel changes in lung connective tissue composition in bleomycin-induced pulmonary fibrosis in hamsters.

1979 • 76 citations

Serum type III procollagen peptide concentration in cryptogenic fibrosing alveolitis and its clinical relevance.

1984 • 76 citations

Human platelet-derived growth factor stimulates amino acid transport and protein synthesis by human diploid fibroblasts in plasma-free media.

1982 • 72 citations

Purification of human interleukin 1

1980 • 72 citations

Macrophage-Derived Growth Factor for Fibroblasts and Interleukin-1 Are Distinct Entities

1984 • 71 citations

Pulmonary fibrosis in experimental acute respiratory disease.

1981 • 69 citations

HUMAN INTERLEUKIN 1: PURIFICATION AND PROPERTIES

1982 • 66 citations

Ultrastructural study of bleomycin‐induced pulmonary changes in mice

1978 • 65 citations

Human monocyte stimulation of fibroblast growth by a soluble mediator(s).

1980 • 64 citations

Secretion of Macrophage-Derived Growth Factor During Acute Lung Injury Induced by Bleomycin

1985 • 60 citations

Differential effects of human interleukin-1 on growth of human fibroblasts and vascular smooth muscle cells.

1985 • 58 citations

In vitro characteristics of the lipid‐filled interstitial cell associated with postnatal lung growth: Evidence for fibroblast heterogeneity

1984 • 57 citations

Variation in collagen expression by cloned periodontal ligament cells

1983 • 57 citations

Effects of procollagen peptides on the translation of type II collagen messenger ribonucleic acid and on collagen biosynthesis in chondrocytes

1981 • 55 citations

Increased contractility of isolated lung parenchyma in an animal model of pulmonary fibrosis induced by bleomycin.

1982 • 54 citations

Production of Growth Factor Activity for Fibroblasts by Human Monocyte-Derived Macrophages

1984 • 52 citations

Cryptogenic fibrosing alveolitis: prediction of fibrogenic activity from immunohistochemical studies of collagen types in lung biopsy specimens.

1983 • 51 citations

Platelet‐derived growth factor stimulates rapid polyphosphoinositide breakdown in fetal human fibroblasts

1985 • 48 citations

Mitogenic activity elaborated by macrophage-like cell lines acts as competence factor(s) for BALB/c 3T3 cells

1982 • 47 citations

Effect of short- or long-term treatment with exogenous glycosaminoglycans on growth and glycosaminoglycan synthesis of human fibroblasts (WI-38) in culture

1980 • 47 citations

Substrain heterogeneity in prostaglandin E₂ synthesis of human dermal fibroblasts. Differences in prostaglandin E₂ synthetic capacity of substrains are not stimulus‐restricted

1985 • 44 citations

Synthesis of collagen, collagenase and collagenase inhibitors by cloned human gingival fibroblasts and the effect of Concanavalin A

1982 • 42 citations

Lymphokine/Monokine Inhibition of Fibroblast Proliferation and Collagen Production: Role in Progressive Systemic Sclerosis (PSS)

1984 • 41 citations

Interstitial Pulmonary Fibrosis

1986 • 39 citations

Paraquat-induced changes in the rate of collagen biosynthesis by rat lung explants.

1978 • 36 citations

The heterogeneity of human fibroblasts as determined from the effects of hydrocortisone on cell growth and specific dexamethasone binding

1985 • 30 citations

Glycosaminoglycan synthesis is depressed during mitosis and elevated during early G1.

1985 • 29 citations

Release of amino-terminal procollagen peptides in paraquat-induced acute pulmonary fibrosis

1984 • 28 citations

Intercellular communication and the control of growth: XI. Alteration of junctional permeability by thesrc gene in a revertant cell with normal cytoskeleton

1984 • 25 citations

Regulation of growth of human diploid fibrobalasts by factors elaborated by activated lymphoid cells

1982 • 24 citations

Some aspects of the modulation and regulation of collagen synthesis in vitro

1981 • 23 citations

Inhibition of lung fibroblast growth by human lung mononuclear cells.

1984 • 22 citations

Stimulation of collagen production in growth-arrested myocytes and fibroblasts in culture by growth factor(s) from platelets

1981 • 22 citations

Insulin Effects on Collagen and Protein Production in Cultured Human Skin Fibroblasts from Diabetic and Non-Diabetic Subjects

1984 • 21 citations

Characterization of the release of human monocyte regulators of fibroblast proliferation.

1982 • 20 citations

Actin content of normal and of bleomycin-fibrotic rat lung.

1984 • 20 citations

Characterization of fibroblast proliferation factors elaborated by antigen- and mitogen-stimulated guinea pig lymph node cells: Differentiation from lymphocyte-derived chemotactic factor for fibroblasts, lymphocyte mitogenic factor, and interleukin 1

1982 • 19 citations

Selective inhibition of excessive scleroderma fibroblast collagen production by lymphokines from normal human mononuclear cells

1985 • 19 citations

Characterization of a lymphokine produced by human T cells which inhibits collagen synthesis

1983 • 17 citations

Response of the aging hamster lung to elastase injury.

1982 • 15 citations

The Polyphosphoinositides Revisited

1985 • 15 citations

A Molecular Basis for Bleomycin-induced Pulmonary Fibrosis

1986 • 13 citations

The effect of lymphokines on proliferation and collagen synthesis of cultured human synovial cells

1982 • 13 citations

Isoelectric focusing of macrophage culture media and the effect of the fractions on the synthesis of DNA and collagen by fibroblasts.

1979 • 12 citations

Effect of prolonged prostaglandin exposure on prostaglandin synthesis by human lung fibroblasts

1984 • 9 citations

Mononuclear cell supernatants inhibit prolyl hydroxylation

1985 • 4 citations

Alterations in the Cellular Population of the Alveolar Wall in an Animal Model of Fibrosis

1986 • 4 citations