Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis.

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

1986 • 570 citations

Increased Production and Immunohistochemical Localization of Transforming Growth Factor-α in Idiopathic Pulmonary Fibrosis

1991 • 511 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

Lung Cytokine Production in Bleomycin-Induced Pulmonary Fibrosis

1992 • 321 citations

Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system

1991 • 303 citations

Differential expression of TGF β1, β2 and β3 genes during mouse embryogenesis

1991 • 296 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

Transforming Growth Factor-β2: cDNA Cloning and Sequence Analysis

1988 • 200 citations

Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice.

1988 • 199 citations

Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat.

1993 • 185 citations

Inhibition of endogenous tissue alkaline phosphatase with the use of alkaline phosphatase conjugates in immunohistochemistry.

1981 • 179 citations

Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines.

1987 • 176 citations

Expression of TGF-β isoforms during first trimester human embryogenesis

1990 • 139 citations

Increased expression of transforming growth factor beta isoforms (beta 1, beta 2, beta 3) in bleomycin-induced pulmonary fibrosis.

1995 • 135 citations

Coordinate regulation of transforming growth factor beta gene expression and cell proliferation in hamster lungs undergoing bleomycin-induced pulmonary fibrosis.

1989 • 134 citations

Expression of Transforming Growth Factor-β₁, -β₂, and -β₃ mRNA and Protein in the Murine Lung

1991 • 127 citations

Bleomycin-induced injury and metaplasia of alveolar type 2 cells. Relationship of cellular responses to drug presence in the lung.

1979 • 125 citations

TGF‐β_S and TGF‐β type II receptor in human epidermis: Differential expression in acute and chronic skin wounds

1993 • 122 citations

Immunohistochemical localization of transforming growth factor‐β₁ in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders

1994 • 115 citations

Recombinant Transforming Growth Factor Type β3: Biological Activities and Receptor-Binding Properties in Isolated Bone Cells

1990 • 105 citations

Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors

1988 • 94 citations

Bleomycin Regulation of Transforming Growth Factor-β mRNA in Rat Lung Fibroblasts

1992 • 84 citations

Synthesis and Expression of Transforming Growth Factor β-1, β-2, and β-3 in the Endocrine and Exocrine Pancreas

1993 • 82 citations

Pathogenesis of lung fibrosis and potential new therapeutic strategies.

1995 • 80 citations

Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction

1992 • 78 citations

The effect of transforming growth factor β on rates of procollagen synthesis and degradation in vitro

1991 • 77 citations

Role of mesothelial and submesothelial stromal cells in matrix remodeling following pleural injury.

1993 • 76 citations

Biochemical and histological changes in pulmonary fibrosis induced in rabbits with intratracheal bleomycin

1981 • 71 citations

Regulation of type II alveolar epithelial cell proliferation by TGF-beta during bleomycin-induced lung injury in rats

1994 • 65 citations

Expression of growth factor and growth factor receptor RNA in rat pleural mesothelial cells in culture

1990 • 60 citations

Application of high-pressure liquid chromatography to studies of collagen production by isolated cells in culture

1990 • 58 citations

PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis.

1993 • 55 citations

Structural and Sequence Analysis of TGF-β2 cDNA Clones Predicts Two Different Precursor Proteins Produced by Alternative mRNA Splicing

1988 • 53 citations

Regulation of fibroblast procollagen production. Transforming growth factor-β1 induces prostaglandin E2 but not procollagen synthesis via a pertussis toxin-sensitive G-protein

1995 • 48 citations

Neutralization of transforming growth factor-beta 1 in a mouse model of immune-induced lung fibrosis.

1994 • 47 citations

Expression of transforming growth factor-beta mRNAs and proteins in pulmonary vascular remodeling in the sheep air embolization model of pulmonary hypertension.

1994 • 47 citations

Auto-induction of Transforming Growth Factor-β in Human Lung Fibroblasts

1993 • 45 citations

Pleural mesothelial cell response to inflammation: tumor necrosis factor-induced mitogenesis and collagen synthesis

1993 • 45 citations

Mesothelial cell proliferation: a nonspecific response to lung injury associated with fibrosis.

1994 • 44 citations

Enhanced type III collagen gene expression during bleomycin induced lung fibrosis.

1993 • 40 citations

Cytokine signaling in lung: transforming growth factor-beta secretion by lung fibroblasts

1991 • 38 citations

Cadmium selectively inhibits fibroblast procollagen production and proliferation

1994 • 26 citations

Increased type I procollagen mRNA transcripts in the lungs of mice during the development of bleomycin-induced fibrosis

1994 • 23 citations

The effect of transforming growth factor-β on fibroblast cell proliferation in intact connective tissue in vitro

1994 • 10 citations

Bleomycin Stimulates Production of Transforming Growth Factor-β by Rat Pulmonary Artery Endothelial Cells

1991 • 8 citations