Hematopoietic Stem and Progenitor Cells

Functional rafts in cell membranes

1997 • 9,471 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Bone Marrow Transplant

2001 • 3,479 citations

Bone marrow transplant

1989 • 3,423 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Bone Marrow Transplant

1990 • 2,745 citations

THE DEVELOPMENT OF FIBROBLAST COLONIES IN MONOLAYER CULTURES OF GUINEA‐PIG BONE MARROW AND SPLEEN CELLS

1970 • 2,595 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

1996 • 2,160 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

The biology of interleukin-6

1989 • 1,964 citations

AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells

1997 • 1,755 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

1999 • 1,714 citations

The biology of interleukin-6

1989 • 1,459 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

1997 • 1,116 citations

Placental Blood as a Source of Hematopoietic Stem Cells for Transplantation into Unrelated Recipients

1996 • 1,053 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Human IL-17: a novel cytokine derived from T cells.

1995 • 1,014 citations

The Granulocyte-Macrophage Colony-Stimulating Factors

1985 • 1,007 citations

Physiological Migration of Hematopoietic Stem and Progenitor Cells

2001 • 938 citations

A Novel Five-Transmembrane Hematopoietic Stem Cell Antigen: Isolation, Characterization, and Molecular Cloning

1997 • 935 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

2000 • 868 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Erythropoietin

1991 • 852 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice

2000 • 760 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 642 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

Long-term culture of human bone marrow cells.

1980 • 624 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease

1995 • 607 citations

Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells

1997 • 603 citations

Stem Cell Concepts

1979 • 569 citations

Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane

2000 • 557 citations

Engraftment after infusion of CD34+ marrow cells in patients with breast cancer or neuroblastoma

1991 • 538 citations

Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML

1994 • 502 citations

Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization

2001 • 487 citations

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation

1990 • 470 citations

A functional comparison of CD34 + CD38- cells in cord blood and bone marrow

1995 • 456 citations

The Human AC133 Hematopoietic Stem Cell Antigen Is also Expressed in Epithelial Cells and Targeted to Plasma Membrane Protrusions

2000 • 434 citations

Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells

1994 • 418 citations

In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment

1998 • 417 citations

Ontogeny-related changes in proliferative potential of human hematopoietic cells.

1993 • 413 citations

Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

1996 • 390 citations

Reconstitution of Hematopoiesis after High-Dose Chemotherapy by Autologous Progenitor Cells Generated ex Vivo

1995 • 382 citations

Post-Golgi biosynthetic trafficking

1997 • 373 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function

1995 • 340 citations

Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin

1993 • 334 citations

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells

1994 • 319 citations

Prominin: A Story of Cholesterol, Plasma Membrane Protrusions and Human Pathology

2001 • 309 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 291 citations

Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

1996 • 281 citations

Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures

1993 • 280 citations

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

1998 • 271 citations

Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C

2000 • 266 citations

Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.

1995 • 265 citations

The CXC Chemokine Stromal Cell-Derived Factor Activates a Gi-Coupled Phosphoinositide 3-Kinase in T Lymphocytes

1999 • 253 citations

Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine.

1981 • 252 citations

Stem Cell Factor/c-kit Up-regulates Cyclin D3 and Promotes Cell Cycle Progression via the Phosphoinositide 3-Kinase/p70 S6 Kinase Pathway in Spermatogonia

2000 • 248 citations

Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long-term in vitro hematopoiesis

1992 • 245 citations

Enrichment, characterization, and responsiveness of single primitive CD34 human umbilical cord blood hematopoietic progenitors with high proliferative and replating potential

1993 • 235 citations

Transforming growth factor-beta. Multiple actions and potential clinical applications

1989 • 229 citations

Polarization of Chemokine Receptors to the Leading Edge during Lymphocyte Chemotaxis

1997 • 219 citations

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

1988 • 211 citations

Implantation and maintenance of functional human bone marrow in SCID-hu mice

1992 • 209 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 190 citations

Extracellular matrix production by the adherent cells of long-term murine bone marrow cultures

1983 • 184 citations

Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer

1996 • 184 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 184 citations

Cytokine-dependent long-term culture of highly enriched precursors of hematopoietic progenitor cells from human bone marrow.

1990 • 171 citations

AC133 expression in human stem cells

2001 • 171 citations

Refining the telomere-telomerase hypothesis of aging and cancer

1996 • 170 citations

Thrombopoietin, kit Ligand, and flk2/flt3 Ligand Together Induce Increased Numbers of Primitive Hematopoietic Progenitors From Human CD34+Thy-1+Lin− Cells With Preserved Ability to Engraft SCID-hu Bone

1998 • 170 citations

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.

1999 • 155 citations

Blood cell cytoadhesion molecules.

1992 • 152 citations

Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture.

1989 • 149 citations

Hematopoietic Stem Cells with High Proliferative Potential

1982 • 147 citations

Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential

1994 • 139 citations

Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase.

1992 • 133 citations

Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans.

1981 • 132 citations

Haemonectin, a bone marrow adhesion protein specific for cells of granulocyte lineage

1987 • 131 citations

Expansion of Hematopoietic Progenitor Cell Populations in Stirred Suspension Bioreactors of Normal Human Bone Marrow Cells

1994 • 131 citations

Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells

2000 • 131 citations

Evaluation of the in vitro behavior of phenotypically defined populations of umbilical cord blood hematopoietic progenitor cells.

1994 • 129 citations

The leukemia inhibitory factor (LIF)

1991 • 127 citations

Interleukin-8: A Review

1993 • 127 citations

Comparison of purity and enrichment of CD34 ⁺ cells from bone marrow, umbilical cord and peripheral blood (primed for apheresis) using five separation systems

1995 • 122 citations

CD34-positive cells isolated from cryopreserved peripheral-blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity.

1996 • 114 citations

Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation

1990 • 114 citations

Proteoglycans in human long-term bone marrow cultures: biochemical and ultrastructural analyses

1986 • 111 citations

Antigenic Analysis of Hematopoiesis: A Review

1993 • 109 citations

The chemokine SDF-1α triggers a chemotactic response and induces cell polarization in human B lymphocytes

1998 • 108 citations

Expansion of Human Bone Marrow Progenitor Cells in a High Cell Density Continuous Perfusion System

1993 • 108 citations

Thrombospondin functions as a cytoadhesion molecule for human hematopoietic progenitor cells

1990 • 107 citations

Experiences of the first 493 unrelated marrow donors in the National Marrow Donor Program

1993 • 106 citations

Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects

1995 • 105 citations

Clinical-scale human umbilical cord blood cell expansion in a novel automated perfusion culture system

1998 • 104 citations

Roles of Chemokines and Receptor Polarization in NK-Target Cell Interactions

1998 • 102 citations

Leukocyte-Endothelium Interaction Promotes SDF-1-dependent Polarization of CXCR4

2003 • 99 citations

Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability.

1989 • 98 citations

Expansion of Primitive Human Hematopoietic Progenitors in a Perfusion Bioreactor System with IL-3, IL-6, and Stem Cell Factor

1993 • 98 citations

Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells – a combination of apical sorting and retention in plasma membrane protrusions

1999 • 98 citations

Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines

1993 • 96 citations

Long-term marrow culture: an overview of techniques and experience.

1984 • 92 citations

Methodology of long-term culture of human hemopoietic cells

1991 • 91 citations

Engraftment of immune-deficient mice with primitive hematopoietic cells from β-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols

1995 • 91 citations

Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures.

1991 • 91 citations

Effects of recombinant human granulocyte colony-stimulating factor (CSF), human granulocyte macrophage-CSF, and gibbon interleukin-3 on hematopoiesis in human long-term bone marrow culture

1990 • 90 citations

Alternative mechanisms with and without steel factor support primitive human hematopoiesis

1993 • 90 citations

Lineage- and stage-specific adhesion of human hematopoietic progenitor cells to extracellular matrices from marrow fibroblasts

1988 • 89 citations

Interleukin 10

1991 • 87 citations

Effects of CD34+ cell selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells

1995 • 84 citations

Granulopoiesis Longevity in Continuous Bone Marrow Cultures and Factor-Dependent Cell Line Generation: Significant Variation Among 28 Inbred Mouse Strains and Outbred Stocks<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1982 • 83 citations

Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function

2002 • 83 citations

Long-term marrow culture of cells from patients with acute myelogenous leukemia. Selection in favor of normal phenotypes in some but not all cases.

1985 • 82 citations

Stem cell quiescence/activation is reversible by serial transplantation and is independent of stromal cell genotype in mouse aggregation chimeras.

1992 • 80 citations

Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines

1993 • 77 citations

The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update.

1989 • 75 citations

Bone marrow transplantation activity in Europe 1990. European Group for Bone Marrow Transplantation (EBMT)

1991 • 73 citations

Growth of macroscopic human megakaryocyte colonies from cord blood in culture with recombinant human thrombopoietin (c‐mpl ligand) and the effects of gestational age on frequency of colonies

1996 • 71 citations

An update from the International Bone Marrow Transplant Registry and the Autologous Blood and Marrow Transplant Registry on current activity in hematopoietic stem cell transplantation

1997 • 68 citations

SDF-1–induced actin polymerization and migration in human hematopoietic progenitor cells

2001 • 68 citations

A rapid sample preparation technique for flow cytometric analysis of immunofluorescence allowing absolute enumeration of cell subpopulations

1989 • 65 citations

In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors

1991 • 59 citations

Marrow repopulating cells, but not CFU-S, establish long-term in vitro hemopoiesis on a marrow-derived stromal layer.

1990 • 58 citations

Hematopoietic stem cells and their precursors: developmental diversity and lineage relationships

2002 • 58 citations

Long-term reconstitution of mice after ex vivo expansion of bone marrow cells: differential activity of cultured bone marrow and enriched stem cell populations.

1994 • 58 citations

In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors

1991 • 58 citations

Isolation of small, primitive human hematopoietic stem cells: distribution of cell surface cytokine receptors and growth in SCID-Hu mice

1995 • 57 citations

Interleukin-16

1997 • 55 citations

Bioreactor Expansion of Human Bone Marrow: Comparison of Unprocessed, Density-Separated, and CD34-Enriched Cells

1995 • 49 citations

Importance of Parenchymal: Stromal Cell Ratio for the Ex Vivo Reconstitution of Human Hematopoiesis

1997 • 47 citations

Ex vivo incubation with growth factors enhances the engraftment of fetal hematopoietic cells transplanted in sheep fetuses

1992 • 46 citations

Donor-to-donor variability in the expansion potential of human bone marrow cells is reduced by accessory cells but not by soluble growth factors.

1996 • 45 citations

Alternatives to Animal Sera for Human Bone Marrow Cell Expansion: Human Serum and Serum-Free Media

1998 • 43 citations

Immunological functions of macrophages and their regulation by interferons.

1985 • 39 citations

Growth factor consumption and production in perfusion cultures of human bone marrow correlate with specific cell production.

1995 • 39 citations

Functional characterization of podia formation in normal and malignant hematopoietic cells

2002 • 39 citations

Analytical review of structure and regulation of hemopoiesis.

1988 • 36 citations

Stromal cells from the bone marrow: Evidence for a restrictive role in regulation of hemopoiesis

1989 • 36 citations

Serum‐free culture of hematopoietic stem cells: A Review

1995 • 35 citations

Tissue culture surface characteristics influence the expansion of human bone marrow cells

1998 • 34 citations

Different measures of human hematopoietic cell culture performance are optimized under vastly different conditions

2000 • 34 citations

flt-3Ligand Is More Potent Thanc-kitLigand for the Synergistic Stimulation of Ex Vivo Hematopoietic Cell Expansion

1996 • 33 citations

Cellular interactions between 3T3 cells and interleukin‐3‐dependent multipotent haemopoietic cells: A model system for stromal‐cell‐mediated haemopoiesis

1989 • 33 citations

Clinical and laboratory comparison study of refrigerated and cryopreserved bone marrow for transplantation.

1994 • 31 citations

Abstammung und Entstehung der rothen Blutzelle

1898 • 24 citations

The effects of interleukin 7 (IL-7) on human bone marrow in vitro.

1991 • 23 citations

BONE MARROW PROCESSING and PURGING

2020 • 19 citations

Purification of human marrow progenitor cells and demonstration of the direct action of macrophage colony-stimulating factor on colony-forming unit-macrophage

1991 • 19 citations

Ex Vivo Hematopoietic Cell Expansion for Bone Marrow Transplantation

1999 • 16 citations

Quantitative Long-Term Culture-Initiating Cell Assays Require Accessory Cell Depletion That Can Be Achieved by CD34-Enrichment or 5-Fluorouracil Exposure

1998 • 15 citations

Serum‐free liquid marrow culture in patients with acute lymphoblastic leukaemia: a potential application to purge marrow for autologous transplantation

1991 • 13 citations

In vitro characterization of fetal hematopoietic stem cells: Range and kinetics of cell production from individual stem cells

1996 • 7 citations

Clinical Systems for the Production of Cells and Tissues for Human Therapy

1999 • 3 citations