Alternative mechanisms with and without steel factor support primitive human hematopoiesis

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment

1987 • 636 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators

1991 • 369 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule

1991 • 331 citations

Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer

1983 • 296 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells

1991 • 261 citations

Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages.

1988 • 239 citations

Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow.

1992 • 231 citations

Life span of multipotential hematopoietic stem cells in vivo.

1990 • 228 citations

Growth and Differentiation in the Hemopoietic System

1987 • 220 citations

Role of c-kit ligand in the expansion of human hematopoietic progenitor cells

1992 • 218 citations

Deletion of the c-kit protooncogene in the human developmental defect piebald trait.

1991 • 212 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 202 citations

Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow

1991 • 195 citations

Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood, and fetal liver: functional properties and composite antigenic profile

1991 • 188 citations

Synergistic factors for stem cell proliferation: further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor

1988 • 176 citations

Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level.

1992 • 174 citations

Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture.

1989 • 149 citations

Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.

1992 • 144 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 141 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 121 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 93 citations

The human hematopoietic stem cell in vitro and in vivo.

1992 • 54 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 36 citations

Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule

1991 • 36 citations

Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells

1991 • 35 citations

Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer

1983 • 28 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 22 citations

Synergistic factors for stem cell proliferation: further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor

1988 • 17 citations

Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood, and fetal liver: functional properties and composite antigenic profile

1991 • 14 citations

Lack of apparent hematologic abnormalities in human patients with c-kit (stem cell factor receptor) gene mutations [letter]

1992 • 8 citations