flt-3Ligand Is More Potent Thanc-kitLigand for the Synergistic Stimulation of Ex Vivo Hematopoietic Cell Expansion

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

The Granulocyte-Macrophage Colony-Stimulating Factors

1985 • 1,007 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Regulation of Hemopoiesis by Bone Marrow Stromal Cells and Their Products

1990 • 546 citations

Hematopoietic regulators: redundancy or subtlety?

1993 • 473 citations

The evaluation of limiting dilution assays

1982 • 458 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators

1991 • 369 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin

1993 • 334 citations

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells

1994 • 319 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 291 citations

A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays

1993 • 283 citations

Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures

1993 • 280 citations

Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors

1995 • 240 citations

Enrichment, characterization, and responsiveness of single primitive CD34 human umbilical cord blood hematopoietic progenitors with high proliferative and replating potential

1993 • 235 citations

The essential cells of the hemopoietic microenvironment.

1984 • 206 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 202 citations

Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells.

1995 • 168 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors

1995 • 162 citations

Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells

1995 • 159 citations

Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells

1994 • 153 citations

Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation

1995 • 149 citations

Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells

1994 • 137 citations

Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells

1996 • 137 citations

Expansion of Hematopoietic Progenitor Cell Populations in Stirred Suspension Bioreactors of Normal Human Bone Marrow Cells

1994 • 131 citations

FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units

1995 • 129 citations

In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells

1993 • 121 citations

Human multipotential progenitor cells (CFU-GEMM) have extensive replating capacity for secondary CFU-GEMM: an effect enhanced by cord blood plasma

1993 • 112 citations

Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects

1995 • 105 citations

The ligand for c-kit, stem cell factor, stimulates the circulation of cells that engraft lethally irradiated baboons

1992 • 95 citations

Maintenance of high levels of pluripotent hematopoietic stem cells in vitro: effect of stromal cells and c-kit

1993 • 92 citations

Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures.

1991 • 91 citations

Alternative mechanisms with and without steel factor support primitive human hematopoiesis

1993 • 90 citations

Effects of CD34+ cell selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells

1995 • 84 citations

Close range cell:cell interaction required for stem cell maintenance in continuous bone marrow culture.

1981 • 77 citations

In vivo administration of recombinant methionyl human stem cell factor expands the number of human marrow hematopoietic stem cells

1993 • 76 citations

Multilineal hematopoiesis in a three-dimensional murine long-term bone marrow culture.

1995 • 71 citations

Review: Tissue engineering: Reconstitution of human hematopoiesis ex vivo

1993 • 68 citations

In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors

1991 • 59 citations

In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors

1991 • 58 citations

Bioreactor Expansion of Human Bone Marrow: Comparison of Unprocessed, Density-Separated, and CD34-Enriched Cells

1995 • 49 citations

The estimation of bacterial densities from dilution series

1951 • 39 citations

Growth factor consumption and production in perfusion cultures of human bone marrow correlate with specific cell production.

1995 • 39 citations

Different measures of human hematopoietic cell culture performance are optimized under vastly different conditions

2000 • 34 citations

Frequent harvesting from perfused bone marrow cultures results in increased overall cell and progenitor expansion

1994 • 22 citations

Replating of bioreactor expanded human bone marrow results in extended growth of primitive and mature cells

1995 • 7 citations

Replating of bioreactor expanded human bone marrow results in extended growth of primitive and mature cells

1995 • 4 citations