Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny

1980 • 837 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Long-term culture of human bone marrow cells.

1980 • 624 citations

The evaluation of limiting dilution assays

1982 • 458 citations

Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators

1991 • 369 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse

1991 • 267 citations

Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells

1991 • 261 citations

Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long-term in vitro hematopoiesis

1992 • 245 citations

Role of c-kit ligand in the expansion of human hematopoietic progenitor cells

1992 • 218 citations

Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture.

1989 • 149 citations

Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.

1992 • 144 citations

Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation

1990 • 114 citations

Expansion of Human Bone Marrow Progenitor Cells in a High Cell Density Continuous Perfusion System

1993 • 108 citations

Long-term marrow culture: an overview of techniques and experience.

1984 • 92 citations

Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures.

1991 • 91 citations

Methodology of long-term culture of human hemopoietic cells

1991 • 91 citations

Effects of recombinant human granulocyte colony-stimulating factor (CSF), human granulocyte macrophage-CSF, and gibbon interleukin-3 on hematopoiesis in human long-term bone marrow culture

1990 • 90 citations

Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines.

1992 • 72 citations

Review: Tissue engineering: Reconstitution of human hematopoiesis ex vivo

1993 • 68 citations

In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors

1991 • 59 citations

Culture perfusion schedules influence the metabolic activity and granulocyte‐macrophage colony‐stimulating factor production rates of human bone marrow stromal cells

1991 • 59 citations

Marrow repopulating cells, but not CFU-S, establish long-term in vitro hemopoiesis on a marrow-derived stromal layer.

1990 • 58 citations

Human interleukin 2

1987 • 57 citations

Allogeneic bone marrow transplantation for leukemia with marrow grafts depleted of lymphocytes by counterflow centrifugation

1990 • 57 citations

The human hematopoietic stem cell in vitro and in vivo.

1992 • 54 citations

The effects of interleukin 6 and interleukin 3 on early hematopoietic events in long-term cultures of human marrow.

1991 • 47 citations

The estimation of bacterial densities from dilution series

1951 • 39 citations

Human interleukin (IL)-9 specifically stimulates proliferation of CD34+++DR+CD33- erythroid progenitors in normal human bone marrow in the absence of serum.

1992 • 35 citations

Proliferation of human hematopoietic progenitors in long-term bone marrow cultures in gas-permeabile plastic bags is enhanced by colony-stimulating factors

1992 • 24 citations

Stromal populations and fibrosis in human long-term bone marrow cultures.

1991 • 15 citations

New Horizons for Stem–Cell Bioreactors

1992 • 15 citations

Evaluation of hematopoiesis in long-term bone marrow culture: comparison of species differences.

1984 • 6 citations

Long-term culture of human granulocytes and granulocyte progenitor cells.

1986 • 3 citations