The Metabolic Syndrome
Data up to Jan 2025
Total Citations Per Year
Abstract
References (641)
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
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Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults
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Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
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Prevalence of the Metabolic Syndrome Among US Adults
2002 • 6,823 citations
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2003 • 6,067 citations
Definition of Metabolic Syndrome
2004 • 5,872 citations
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 • 5,744 citations
Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels
1998 • 5,293 citations
Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet
2001 • 5,241 citations
Adipose Tissue as an Endocrine Organ
2004 • 5,220 citations
The Metabolic Syndrome and Total and Cardiovascular Disease Mortality in Middle-aged Men
2002 • 5,087 citations
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Prevalence of Overweight and Obesity Among US Children, Adolescents, and Adults, 1999-2002
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2003 • 4,328 citations
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2001 • 4,289 citations
Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes Study
1997 • 4,262 citations
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1998 • 3,814 citations
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial
2004 • 3,776 citations
Banting lecture 1988. Role of insulin resistance in human disease
1988 • 3,751 citations
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 • 3,671 citations
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
2002 • 3,568 citations
Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol
1999 • 3,464 citations
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
1995 • 3,454 citations
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
2004 • 3,444 citations
Obesity and the Metabolic Syndrome in Children and Adolescents
2004 • 3,423 citations
Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy
2000 • 3,103 citations
Overweight and obesity in the United States: prevalence and trends, 1960–1994
1997 • 3,098 citations
Obesity and insulin resistance
2000 • 3,076 citations
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 • 2,992 citations
Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complications After Myocardial Infarction
1999 • 2,892 citations
Obesity and the Risk of Heart Failure
2002 • 2,840 citations
Diet, Lifestyle, and the Risk of Type 2 Diabetes Mellitus in Women
2001 • 2,812 citations
The Continuing Epidemics of Obesity and Diabetes in the United States
2001 • 2,803 citations
Cellular mechanisms of insulin resistance
2000 • 2,692 citations
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
2002 • 2,503 citations
Insulin Resistance in Essential Hypertension
1987 • 2,386 citations
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1999 • 2,323 citations
Who Would Have Thought It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes Mellitus
1995 • 2,296 citations
Prevalence of a Metabolic Syndrome Phenotype in Adolescents
2003 • 2,295 citations
C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events
2003 • 2,283 citations
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
2002 • 2,244 citations
Gestational Diabetes and the Incidence of Type 2 Diabetes
2002 • 2,158 citations
Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
2003 • 2,157 citations
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
2004 • 2,151 citations
Adipokines: inflammation and the pleiotropic role of white adipose tissue
2004 • 2,127 citations
Exercise and Physical Activity in the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
2003 • 2,121 citations
The Metabolic Syndrome
2003 • 2,081 citations
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
1999 • 2,051 citations
Plasma Triglyceride Level is a Risk Factor for Cardiovascular Disease Independent of High-Density Lipoprotein Cholesterol Level: A Metaanalysis of Population-Based Prospective Studies
1996 • 2,037 citations
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
2003 • 2,035 citations
Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease
2001 • 1,999 citations
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
1982 • 1,919 citations
AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update
2002 • 1,909 citations
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
2004 • 1,897 citations
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
2002 • 1,885 citations
Reducing Children's Television Viewing to Prevent Obesity
1999 • 1,879 citations
Overweight and Obesity as Determinants of Cardiovascular Risk
2002 • 1,845 citations
XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study
2004 • 1,832 citations
A Randomized Trial of a Low-Carbohydrate Diet for Obesity
2003 • 1,809 citations
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
2004 • 1,794 citations
Dietary Fat Intake and the Risk of Coronary Heart Disease in Women
1997 • 1,785 citations
Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults
2004 • 1,766 citations
Vascular Endothelial Growth Factor and Angiogenesis
2004 • 1,763 citations
Role of oxygen radicals in DNA damage and cancer incidence
2004 • 1,762 citations
A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
2001 • 1,743 citations
Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Marked Obesity
2002 • 1,732 citations
Cardiovascular Risk Factors in Childhood and Carotid Artery Intima-Media Thickness in Adulthood
2003 • 1,707 citations
Comparison of the Atkins, Ornish, Weight Watchers, and Zone Diets for Weight Loss and Heart Disease Risk Reduction
2005 • 1,702 citations
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
1998 • 1,666 citations
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
2003 • 1,665 citations
Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension in Patients With Impaired Glucose Tolerance
2003 • 1,628 citations
Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women1
1999 • 1,571 citations
The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension
1989 • 1,560 citations
Simple Scoring Scheme for Calculating the Risk of Acute Coronary Events Based on the 10-Year Follow-Up of the Prospective Cardiovascular Münster (PROCAM) Study
2002 • 1,547 citations
Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults
2004 • 1,525 citations
Metabolic Syndrome With and Without C-Reactive Protein as a Predictor of Coronary Heart Disease and Diabetes in the West of Scotland Coronary Prevention Study
2003 • 1,509 citations
NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older
2003 • 1,462 citations
Banting Lecture 2001
2002 • 1,445 citations
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk.
1990 • 1,404 citations
Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men
2000 • 1,379 citations
S<scp>UCCESSFUL</scp> W<scp>EIGHT</scp> L<scp>OSS</scp> M<scp>AINTENANCE</scp>
2001 • 1,374 citations
Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women
2002 • 1,360 citations
The Emergence of the Metabolic Syndrome with Menopause
2003 • 1,350 citations
Statement on Exercise: Benefits and Recommendations for Physical Activity Programs for All Americans
1996 • 1,342 citations
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
1999 • 1,300 citations
Insulin resistance and cardiovascular disease
2000 • 1,280 citations
n-3 fatty acids and serum lipoproteins: human studies
1997 • 1,278 citations
Obstructive Sleep Apnea Is Independently Associated with Insulin Resistance
2002 • 1,276 citations
Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease
2004 • 1,276 citations
Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
1999 • 1,269 citations
A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity
2003 • 1,267 citations
Effect of Aerobic Exercise on Blood Pressure
2002 • 1,264 citations
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
2002 • 1,264 citations
The relative influence of individual, social and physical environment determinants of physical activity
2002 • 1,229 citations
Prospective Analysis of The Insulin-Resistance Syndrome (Syndrome X)
1992 • 1,227 citations
Sodium Reduction and Weight Loss in the Treatment of Hypertension in Older Persons
1998 • 1,208 citations
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
1994 • 1,200 citations
Adiponectin and Metabolic Syndrome
2003 • 1,198 citations
Interleukin-6-deficient mice develop mature-onset obesity
2002 • 1,197 citations
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
1998 • 1,173 citations
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
1999 • 1,151 citations
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
2004 • 1,148 citations
Prevalence of the Metabolic Syndrome and Its Relation to All-Cause and Cardiovascular Mortality in Nondiabetic European Men and Women
2004 • 1,145 citations
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
1997 • 1,133 citations
Adiponectin and protection against type 2 diabetes mellitus
2003 • 1,130 citations
Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
2001 • 1,122 citations
Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle
2000 • 1,119 citations
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
1975 • 1,114 citations
ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins
2002 • 1,114 citations
Prevalence of the Metabolic Syndrome in American Adolescents
2004 • 1,110 citations
Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention
2002 • 1,094 citations
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
1991 • 1,073 citations
Body Mass Index, Serum Sex Hormones, and Breast Cancer Risk in Postmenopausal Women
2003 • 1,058 citations
American College of Endocrinology Position Statement on the Insulin Resistance Syndrome
2003 • 1,055 citations
Metabolic Implications of Body Fat Distribution
1991 • 1,053 citations
Mechanisms of fatty acid-induced inhibition of glucose uptake.
1994 • 1,049 citations
Childhood Cardiovascular Risk Factors and Carotid Vascular Changes in Adulthood
2003 • 1,025 citations
Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
1990 • 1,020 citations
Effects of Oral Potassium on Blood Pressure
1997 • 1,004 citations
Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review.
2002 • 1,002 citations
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
1999 • 1,000 citations
Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach
1989 • 999 citations
The metabolic syndrome: prevalence in worldwide populations
2004 • 997 citations
Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
2004 • 996 citations
Environmental and Policy Determinants of Physical Activity in the United States
2001 • 993 citations
The Influence of Body Fat Distribution on the Incidence of Diabetes Mellitus: 13.5 Years of Follow-up of the Participants in the Study of Men Born in 1913
1985 • 981 citations
Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant
2003 • 971 citations
Lipoprotein Lipase
1989 • 970 citations
C-Reactive Protein and the Risk of Developing Hypertension
2003 • 969 citations
Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women
2005 • 967 citations
Sleep-disordered Breathing and Insulin Resistance in Middle-aged and Overweight Men
2002 • 957 citations
Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence
2001 • 941 citations
Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome
1991 • 930 citations
Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity
1997 • 919 citations
Metabolic Syndrome and Development of Diabetes Mellitus: Application and Validation of Recently Suggested Definitions of the Metabolic Syndrome in a Prospective Cohort Study
2002 • 915 citations
Executive Summary of the Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults
1998 • 912 citations
Hypertriglyceridemic Waist
2000 • 911 citations
A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia
2004 • 911 citations
Beneficial Cardiovascular Pleiotropic Effects of Statins
2004 • 903 citations
Angiotensin-Receptor Blockade versus Converting–Enzyme Inhibition in Type 2 Diabetes and Nephropathy
2004 • 901 citations
Acquired and Inherited Lipodystrophies
2004 • 899 citations
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
2001 • 896 citations
Carotid Intimal-Medial Thickness Is Related to Cardiovascular Risk Factors Measured From Childhood Through Middle Age
2001 • 890 citations
The metabolically obese, normal-weight individual revisited.
1998 • 879 citations
Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
2003 • 869 citations
Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study
2002 • 859 citations
Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years
1998 • 856 citations
The Kidney, Hypertension, and Obesity
2003 • 856 citations
Pravastatin and the Development of Diabetes Mellitus
2001 • 854 citations
Clinical Management of Metabolic Syndrome
2004 • 836 citations
A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women
2003 • 834 citations
The Metabolic Syndrome as Predictor of Type 2 Diabetes
2003 • 814 citations
A Randomized Controlled Trial of Resistance Exercise Training to Improve Glycemic Control in Older Adults With Type 2 Diabetes
2002 • 813 citations
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.
1994 • 813 citations
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
2000 • 805 citations
Carbohydrate Nutrition, Insulin Resistance, and the Prevalence of the Metabolic Syndrome in the Framingham Offspring Cohort
2004 • 794 citations
Glycemic index: overview of implications in health and disease,,,
2002 • 788 citations
Relationship Between Resistance to Insulin-Mediated Glucose Uptake, Urinary Uric Acid Clearance, and Plasma Uric Acid Concentration
1991 • 786 citations
Association of the Metabolic Syndrome With History of Myocardial Infarction and Stroke in the Third National Health and Nutrition Examination Survey
2003 • 779 citations
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
1999 • 771 citations
Obesity and cancer
2004 • 761 citations
Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor Therapy on High Sensitive C-Reactive Protein Levels
2001 • 758 citations
Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
2005 • 758 citations
Cholesterol Lowering With Statin Drugs, Risk of Stroke, and Total Mortality
1997 • 737 citations
Does the Metabolic Syndrome Improve Identification of Individuals at Risk of Type 2 Diabetes and/or Cardiovascular Disease?
2004 • 735 citations
High-Intensity Resistance Training Improves Glycemic Control in Older Patients With Type 2 Diabetes
2002 • 734 citations
Effects of parabiosis of obese with diabetes and normal mice
1973 • 728 citations
Clustering of Metabolic Factors and Coronary Heart Disease
1999 • 726 citations
Inflammatory pathways and insulin action
2003 • 716 citations
Low Cardiorespiratory Fitness and Physical Inactivity as Predictors of Mortality in Men with Type 2 Diabetes
2000 • 710 citations
Exercise‐Induced Reduction in Obesity and Insulin Resistance in Women: a Randomized Controlled Trial
2004 • 684 citations
A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention
1997 • 679 citations
Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: The muscatine study
1996 • 678 citations
National Cholesterol Education Program Versus World Health Organization Metabolic Syndrome in Relation to All-Cause and Cardiovascular Mortality in the San Antonio Heart Study
2004 • 669 citations
Salt and hypertension
1972 • 667 citations
C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring Study
2004 • 664 citations
Role of Orlistat in the Treatment of Obese Patients With Type 2 Diabetes: A 1-year randomized double-blind study
1998 • 655 citations
Low Levels of Leisure-Time Physical Activity and Cardiorespiratory Fitness Predict Development of the Metabolic Syndrome
2002 • 653 citations
Should C-Reactive Protein Be Added to Metabolic Syndrome and to Assessment of Global Cardiovascular Risk?
2004 • 648 citations
Predictive Value for the Chinese Population of the Framingham CHD Risk Assessment Tool Compared With the Chinese Multi-provincial Cohort Study
2004 • 647 citations
Gestational Diabetes Mellitus
1986 • 646 citations
A Comparison of the Prevalence of the Metabolic Syndrome Using Two Proposed Definitions
2003 • 645 citations
Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects
2003 • 641 citations
Effects of Diet and Exercise in Men and Postmenopausal Women with Low Levels of HDL Cholesterol and High Levels of LDL Cholesterol
1998 • 635 citations
Abdominal Fat and Insulin Resistance in Normal and Overweight Women: Direct Measurements Reveal a Strong Relationship in Subjects at Both Low and High Risk of NIDDM
1996 • 630 citations
Metabolic Syndrome: A Clinical and Molecular Perspective
2004 • 630 citations
The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: One-year follow-up of a randomized trial
2004 • 627 citations
Dietary fat, insulin sensitivity and the metabolic syndrome
2004 • 623 citations
Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.
1985 • 617 citations
Glycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial
2003 • 616 citations
Intensity and Amount of Physical Activity in Relation to Insulin Sensitivity
1998 • 611 citations
The Metabolic Syndrome in Overweight Hispanic Youth and the Role of Insulin Sensitivity
2004 • 601 citations
A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis
1969 • 600 citations
Visceral Obesity in Men: Associations With Glucose Tolerance, Plasma Insulin, and Lipoprotein Levels
1992 • 598 citations
Relation of Impaired Fasting and Postload Glucose With Incident Type 2 Diabetes in a Dutch Population
2001 • 597 citations
Components of the “Metabolic Syndrome” and Incidence of Type 2 Diabetes
2002 • 595 citations
A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids
2003 • 592 citations
Relationship between obesity, insulin resistance, and coronary heart disease risk
2002 • 577 citations
Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women’s Health Initiative Hormone Trial
2004 • 570 citations
Abdominal obesity as important component of insulin-resistance syndrome.
1993 • 568 citations
Body size and breast cancer risk: Findings from the European prospective investigation into cancer and nutrition (EPIC)
2004 • 560 citations
Efficacy, Safety, and Tolerability of Once-Daily Niacin for the Treatment of Dyslipidemia Associated With Type 2 Diabetes<subtitle>Results of the Assessment of Diabetes Control and Evaluation of the Efficacy of Niaspan Trial</subtitle>
2002 • 558 citations
Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans
2003 • 557 citations
The Relation between Blood Pressure and Mortality Due to Coronary Heart Disease among Men in Different Parts of the World
2000 • 556 citations
Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States).
2002 • 552 citations
Invited Review: Effects of acute exercise and exercise training on insulin resistance
2002 • 543 citations
The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)
2004 • 543 citations
Hypertriglyceridemia, Atherogenic Dyslipidemia, and the Metabolic Syndrome
1998 • 538 citations
Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study
2003 • 527 citations
The gastric bypass operation reduces the progression and mortality of non-insulin-dependent diabetes mellitus
1997 • 520 citations
Dietary methods research in the third National Health and Nutrition Examination Survey: underreporting of energy intake
1997 • 520 citations
Evidence for Association Between Polycystic Ovary Syndrome and Premature Carotid Atherosclerosis in Middle-Aged Women
2000 • 515 citations
Searching for the exercise factor: is IL-6 a candidate?
2003 • 510 citations
Dietary Sodium Intake and Subsequent Risk of Cardiovascular Disease in Overweight Adults
1999 • 508 citations
Adipocytokines and Insulin Resistance
2004 • 508 citations
Diabetes and Hypertension in Severe Obesity and Effects of Gastric Bypass-Induced Weight Loss
2003 • 501 citations
Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans.
1995 • 500 citations
Accurate Assessment of β-Cell Function
2002 • 496 citations
Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer
1999 • 496 citations
Bariatric Surgery and Long-term Control of Morbid Obesity
2002 • 487 citations
Hormone-sensitive lipase
2002 • 475 citations
Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
2003 • 475 citations
Long-term Effects of Modest Weight Loss in Type II Diabetic Patients
1987 • 475 citations
Physical activity and cancer risk: dose-response and cancer, all sites and site-specific
2001 • 471 citations
Components of the Metabolic Syndrome and Risk of Cardiovascular Disease and Diabetes in Beaver Dam
2002 • 471 citations
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
2002 • 464 citations
Sedentary Lifestyle, Poor Cardiorespiratory Fitness, and the Metabolic Syndrome
2003 • 463 citations
Interleukin-18: A Novel Cytokine That Augments Both Innate and Acquired Immunity
1998 • 458 citations
Food Sources of Added Sweeteners in the Diets of Americans
2000 • 455 citations
A transgenic mouse model for monitoring endoplasmic reticulum stress
2003 • 452 citations
Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted?
2000 • 449 citations
The Metabolic Syndrome and Antioxidant Concentrations
2003 • 444 citations
Nonalcoholic Fatty Liver Disease
2003 • 444 citations
Insulin Resistance, the Metabolic Syndrome, and Risk of Incident Cardiovascular Disease in Nondiabetic American Indians
2003 • 437 citations
Effect of resistance training on resting blood pressure: a meta-analysis of randomized controlled trials
2005 • 434 citations
Social inequality in coronary risk: Central obesity and the metabolic syndrome. Evidence from the Whitehall II study
1997 • 434 citations
Fasting Insulin and Apolipoprotein B Levels and Low-Density Lipoprotein Particle Size as Risk Factors for Ischemic Heart Disease
1998 • 432 citations
Trends in the Incidence of Coronary Heart Disease and Changes in Diet and Lifestyle in Women
2000 • 430 citations
C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites
2001 • 424 citations
Myopathy and Rhabdomyolysis Associated With Lovastatin-Gemfibrozil Combination Therapy
1990 • 422 citations
Influence of Low High-Density Lipoprotein Cholesterol and Elevated Triglyceride on Coronary Heart Disease Events and Response to Simvastatin Therapy in 4S
2001 • 421 citations
Metabolic Significance of Nonalcoholic Fatty Liver Disease in Nonobese, Nondiabetic Adults
2004 • 421 citations
Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice
2004 • 417 citations
In vivo regulation of lipolysis in humans.
1994 • 416 citations
Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
2003 • 416 citations
Adipose tissue angiogenesis1,2
2004 • 414 citations
Invited Commentary: Insulin Resistance Syndrome? Syndrome X? Multiple Metabolic Syndrome? A Syndrome At All? Factor Analysis Reveals Patterns in the Fabric of Correlated Metabolic Risk Factors
2000 • 412 citations
Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity
2002 • 406 citations
The Associations between Obesity, Adipose Tissue Distribution and Disease
1987 • 405 citations
Metabolic syndrome in urban Asian Indian adults—a population study using modified ATP III criteria
2003 • 404 citations
Prevalence and Predictors of Coronary Artery Calcification in Women with Polycystic Ovary Syndrome
2003 • 401 citations
Efficacy and Safety of a New HMG-CoA Reductase Inhibitor, Atorvastatin, in Patients With Hypertriglyceridemia
1996 • 394 citations
Marked Improvement in Carbohydrate and Lipid Metabolism in Diabetic Australian Aborigines After Temporary Reversion to Traditional Lifestyle
1984 • 392 citations
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
2003 • 390 citations
Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia
2002 • 387 citations
Dietary Prevention of Coronary Heart Disease: The Finnish Mental Hospital Study
1979 • 387 citations
Adipose tissue and adipokines: for better or worse
2004 • 381 citations
Underreporting of energy intake in repeated 24-hour recalls related to gender, age, weight status, day of interview, educational level, reported food intake, smoking habits and area of living
2001 • 381 citations
Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome
2002 • 380 citations
The current biology of resistin
2004 • 380 citations
Circulating markers of inflammation and atherosclerosis
2003 • 373 citations
The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical Applications
2002 • 370 citations
Insulin Resistance Syndrome Predicts the Risk of Coronary Heart Disease and Stroke in Healthy Middle-Aged Men
2000 • 359 citations
Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
2003 • 353 citations
Relationship between degree of obesity and in vivo insulin action in man
1985 • 345 citations
Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.
1988 • 338 citations
Trends in the Prevalence and Ratio of Diagnosed to Undiagnosed Diabetes According to Obesity Levels in the U.S.
2004 • 336 citations
Recent Advances in Our Understanding of Insulin Action and Insulin Resistance
2001 • 336 citations
Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
2001 • 332 citations
Effects of parabiosis of normal with genetically diabetic mice
1969 • 326 citations
Effects of an Energy-Restrictive Diet With or Without Exercise on Abdominal Fat, Intermuscular Fat, and Metabolic Risk Factors in Obese Women
2002 • 326 citations
Medical and surgical options in the treatment of severe obesity
2002 • 323 citations
Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels—a prospective and cross-sectional evaluation
2002 • 322 citations
Visceral fat, insulin sensitivity, and lipids in prepubertal children.
1999 • 321 citations
Physical activity decreases cardiovascular disease risk in women
2004 • 320 citations
Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance
2003 • 317 citations
Pleiotropic Effects of Statins: Lipid Reduction and Beyond
2002 • 316 citations
What is the Relationship Between Exercise and Metabolic Abnormalities?
2004 • 314 citations
Selective loss of estrogen receptor beta in malignant human colon.
2000 • 313 citations
Hyperinsulinemia in a Population at High Risk for Non-Insulin-Dependent Diabetes Mellitus
1986 • 311 citations
The Importance of Diagnosing the Polycystic Ovary Syndrome
2000 • 310 citations
Obesity in the Elderly
2001 • 309 citations
Metabolic Syndrome in Normal-Weight Americans
2004 • 309 citations
Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why)
2001 • 309 citations
Prevalence of metabolic syndrome in an Indian urban population
2004 • 307 citations
Insulin Regulation of Lipolysis in Nondiabetic and IDDM Subjects
1989 • 303 citations
Review of anthropometric factors and breast cancer risk
2001 • 303 citations
Prevention of Type 2 Diabetes Mellitus Through Inhibition of the Renin-Angiotensin System
2004 • 302 citations
Obesity Due to Proopiomelanocortin Deficiency: Three New Cases and Treatment Trials with Thyroid Hormone and ACTH4–10
2003 • 302 citations
The beneficial effects of modest weight loss on cardiovascular risk factors.
1997 • 300 citations
A Comparison of the Efficacy and Toxic Effects of Sustained- vs Immediate-Release Niacin in Hypercholesterolemic Patients
1994 • 300 citations
Relative effects of calorie restriction and weight loss in noninsulin- dependent diabetes mellitus
1993 • 300 citations
The weight reduction operation of choice: Vertical banded gastroplasty or gastric bypass?
1996 • 299 citations
Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment.
1984 • 296 citations
Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis
2001 • 294 citations
Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials
2002 • 292 citations
The Metabolic Syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study
2003 • 291 citations
The Metabolic Syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic aneurysm
2004 • 290 citations
Adiponectin, Inflammation, and the Expression of the Metabolic Syndrome in Obese Individuals: The Impact of Rapid Weight Loss through Caloric Restriction
2004 • 290 citations
Effect of thiazolidinediones on body weight in patients with diabetes mellitus
2003 • 287 citations
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise
2004 • 287 citations
Metabolic Regulation: A Human Perspective
1996 • 282 citations
Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation
2005 • 278 citations
Effect of Orlistat in Overweight and Obese Patients With Type 2 Diabetes Treated With Metformin
2002 • 274 citations
Dietary treatment of the metabolic syndrome — the optimal diet
2000 • 272 citations
Prevalence of the Metabolic Syndrome Among Omani Adults
2003 • 272 citations
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma
2002 • 272 citations
The Cardiovascular Risk of Young Women with Polycystic Ovary Syndrome: An Observational, Analytical, Prospective Case-Control Study
2004 • 272 citations
Leptin Effects on Pancreatic β-Cell Gene Expression and Function
2004 • 271 citations
DOUBLE-BLIND STUDY OF THREE SODIUM INTAKES AND LONG-TERM EFFECTS OF SODIUM RESTRICTION IN ESSENTIAL HYPERTENSION
1989 • 270 citations
Does physical activity lower blood pressure: A critical review of the clinical trials
1992 • 270 citations
A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor-γ Gene in a Patient with Familial Partial Lipodystrophy
2002 • 268 citations
Who are the 'low energy reporters' in the dietary and nutritional survey of British adults?
1997 • 268 citations
Multiple Abnormalities in Glucose and Energy Metabolism and Coordinated Changes in Levels of Adiponectin, Cytokines, and Adhesion Molecules in Subjects With Metabolic Syndrome
2004 • 267 citations
Reduction in Cardiovascular Disease Risk Factors: 6-Month Results from ProjectActive
1997 • 265 citations
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
2000 • 265 citations
Serum High-Density Lipoprotein Cholesterol, Metabolic Profile, and Breast Cancer Risk
2004 • 265 citations
Sex Differences in the Effect of Diabetes Mellitus on Lipoprotein Triglyceride and Cholesterol Concentrations
1984 • 264 citations
Evidence for a New Pathophysiological Mechanism for Coronary Artery Disease Regression
1999 • 264 citations
Impact of lifestyle habits on the prevalence of the metabolic syndrome among Greek adults from the ATTICA study
2003 • 261 citations
Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies. A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition
2004 • 260 citations
PPARG F388L, a Transactivation-Deficient Mutant, in Familial Partial Lipodystrophy
2002 • 259 citations
Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia.
1991 • 257 citations
A Novel Pathway to the Manifestations of Metabolic Syndrome
2004 • 254 citations
Dietary Therapy Slows the Return of Hypertension After Stopping Prolonged Medication
1985 • 252 citations
Insulin Resistance and Associated Compensatory Responses in African-American and Hispanic Children
2002 • 250 citations
Effects of Diets Enriched in Saturated (Palmitic), Monounsaturated (Oleic), or trans (Elaidic) Fatty Acids on Insulin Sensitivity and Substrate Oxidation in Healthy Adults
2002 • 248 citations
Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects
2003 • 248 citations
Regional postprandial fatty acid metabolism in different obesity phenotypes.
1999 • 247 citations
Intra‐urban differences in the prevalence of the metabolic syndrome in southern India – the Chennai Urban Population Study (CUPS No. 4)
2001 • 247 citations
High Local Concentrations and Effects on Differentiation Implicate Interleukin‐6 as a Paracrine Regulator
2004 • 245 citations
Fatty acid metabolism and insulin secretion in pancreatic beta cells
2003 • 240 citations
Colorectal cancer mortality and factors related to the insulin resistance syndrome.
2002 • 239 citations
An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia
2001 • 239 citations
Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia**A complete list of participants in the Research Group and Publication Committee appears in the Appendix.
2002 • 239 citations
Long-Term (5-Year) Effects of a Reduced-Fat Diet Intervention in Individuals With Glucose Intolerance
2001 • 238 citations
Hepatic Very Low Density Lipoprotein-ApoB Overproduction Is Associated with Attenuated Hepatic Insulin Signaling and Overexpression of Protein-tyrosine Phosphatase 1B in a Fructose-fed Hamster Model of Insulin Resistance
2002 • 237 citations
Factor Analysis of Metabolic Syndrome Using Directly Measured Insulin Sensitivity
2002 • 233 citations
Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis
2004 • 231 citations
Obesity, Body Fat Distribution, Insulin Sensitivity and Islet β-Cell Function as Explanations for Metabolic Diversity
2001 • 231 citations
Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia
2000 • 230 citations
National Surveillance for Type 2 Diabetes Mellitus in Taiwanese Children
2003 • 230 citations
Low-Density Lipoprotein Size and Cardiovascular Disease: A Reappraisal
2003 • 230 citations
Risk factors for malignant diseases: a cohort study on a population of 22,946 Icelanders.
1997 • 229 citations
Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort
2003 • 223 citations
Acute Effects of Insulin in the Control of VLDL Production in Humans: Implications for the insulin-resistant state
1996 • 220 citations
Determinants of Obesity-related Underreporting of Energy Intake
1998 • 220 citations
Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance
2003 • 219 citations
The Metabolic Syndrome and Inflammation
2004 • 219 citations
Metabolic Syndrome as a Predictor of All-Cause and Cardiovascular Mortality in Type 2 Diabetes
2004 • 218 citations
Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
2000 • 218 citations
Comparison of Effects of High and Low Carbohydrate Diets on Plasma Lipoproteins and Insulin Sensitivity in Patients With Mild NIDDM
1992 • 217 citations
Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study
1993 • 217 citations
Effect of Postmenopausal Hormone Therapy on Body Weight and Waist and Hip Girths1
1997 • 216 citations
Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments?
1994 • 216 citations
Preventing Type 2 diabetes and the dysmetabolic syndrome in the real world: a realistic view
2003 • 215 citations
Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity
2002 • 212 citations
Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids.
1965 • 211 citations
High-Fat, Low-Carbohydrate Diet and the Etiology of Non-Insulin-dependent Diabetes Mellitus: The San Luis Valley Diabetes Study
1991 • 209 citations
Serum Cholesterol Response to Changes in Dietary Lipids
1966 • 207 citations
Are Metabolic Risk Factors One Unified Syndrome? Modeling the Structure of the Metabolic Syndrome X
2003 • 207 citations
Cardiorespiratory Fitness and C-Reactive Protein Among a Tri-Ethnic Sample of Women
2002 • 206 citations
Comparative studies of resistin expression and phylogenomics in human and mouse
2003 • 206 citations
Prevalence of the Metabolic Syndrome and Its Components
2004 • 205 citations
Coagulation and fibrinolysis abnormalities in obesity
2002 • 204 citations
Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression
2004 • 202 citations
Insulin receptor expression and function in human breast cancer cell lines.
1992 • 202 citations
Hypothalamic Origin of the Metabolic Syndrome X
1999 • 200 citations
Risk Factor Groupings Related to Insulin Resistance and Their Synergistic Effects on Subclinical Atherosclerosis
2002 • 199 citations
Lifestyle Changes May Reverse Development of the Insulin Resistance Syndrome. The Oslo Diet and Exercise Study: a randomized trial
1997 • 199 citations
Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans.
1999 • 198 citations
High prevalence of metabolic syndrome in Mexico
2004 • 198 citations
Triglycerides Are Major Determinants of Cholesterol Esterification/Transfer and HDL Remodeling in Human Plasma
1995 • 197 citations
Education and the metabolic syndrome in women.
1999 • 197 citations
Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men
1996 • 196 citations
Is there an association between hypertension and cancer mortality?
2002 • 196 citations
Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men
1991 • 196 citations
Primary Prevention of Cardiovascular Disease and Type 2 Diabetes in Patients at Metabolic Risk: An Endocrine Society Clinical Practice Guideline
2008 • 195 citations
Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients
2004 • 192 citations
Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and β-cell failure?
2000 • 192 citations
Type 2 Diabetes: An Overview
1999 • 192 citations
Markers of insulin resistance and colorectal cancer mortality.
2001 • 190 citations
The insulin resistance syndrome in smokers is related to smoking habits.
1994 • 190 citations
Adiponectin Gene Polymorphisms and Adiponectin Levels Are Independently Associated With the Development of Hyperglycemia During a 3-Year Period
2004 • 189 citations
The fourth Musketeer ? from Alexandre Dumas to Claude Bernard
1995 • 187 citations
Metformin hydrochloride in the treatment of type 2 diabetes mellitus: A clinical review with a focus on dual therapy
2003 • 187 citations
No excess 12-year mortality in men with impaired glucose tolerance who participated in the Malm� Preventive Trial with diet and exercise
1998 • 183 citations
Effects of Exercise, Diet and Weight Loss on High Blood Pressure
2004 • 183 citations
Insulin resistance in childhood obesity.
2002 • 181 citations
Benefits of sustained moderate weight loss in obesity.
2001 • 181 citations
Associations of Location and Perceived Environmental Attributes with Walking in Neighborhoods
2004 • 181 citations
Peripheral metabolic actions of leptin
2002 • 180 citations
The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients
1997 • 180 citations
Correlation of serum triglyceride and its reduction by ω-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins
1999 • 178 citations
THE EFFECTS OF EXERCISE ON BLOOD LIPIDS AND LIPOPROTEINS
1982 • 178 citations
Pathophysiology of obesity hypertension
2000 • 178 citations
Not all fat is alike
1998 • 176 citations
Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy
2001 • 175 citations
Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes
2004 • 175 citations
Reduction of Cardiovascular Events by Simvastatin in Nondiabetic Coronary Heart Disease Patients With and Without the Metabolic Syndrome
2004 • 173 citations
Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff.
1991 • 172 citations
Insulin Signaling in Microdomains of the Plasma Membrane
2003 • 171 citations
Influence of obesity on the metabolism of apolipoprotein B in humans.
1985 • 171 citations
Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease
2004 • 170 citations
Increased Low-Density Lipoprotein Oxidation and Impaired High-Density Lipoprotein Antioxidant Defense Are Associated With Increased Macrophage Homing and Atherosclerosis in Dyslipidemic Obese Mice
2003 • 170 citations
Implications of Oxidative Stress and Cell Membrane Lipid Peroxidation in Human Cancer (Spain)
2004 • 170 citations
Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia.
1998 • 170 citations
Leptin is a growth factor in cancer
2004 • 169 citations
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
2000 • 166 citations
A Unique Defect in the Regulation of Visceral Fat Cell Lipolysis in the Polycystic Ovary Syndrome as an Early Link to Insulin Resistance
2002 • 166 citations
Usual Dietary Fat Intake and Insulin Concentrations in Healthy Women Twins
1993 • 166 citations
Hepatic lipase activity is lower in African American men than in white American men: effects of 5′ flanking polymorphism in the hepatic lipase gene (LIPC)
1998 • 166 citations
Effects of Obesity Surgery on the Metabolic Syndrome
2004 • 165 citations
Mechanisms modifying glucose oxidation in diabetes mellitus
1994 • 165 citations
Dietary fat content alters insulin-mediated glucose metabolism in healthy men
2001 • 165 citations
Characteristics of the low-energy reporters in a longitudinal national dietary survey
1997 • 164 citations
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice
2003 • 163 citations
Macrophage Inhibitory Factor, Plasminogen Activator Inhibitor-1, Other Acute Phase Proteins, and Inflammatory Mediators Normalize as a Result of Weight Loss in Morbidly Obese Subjects Treated with Gastric Restrictive Surgery
2004 • 161 citations
Insulin resistance and the sympathetic nervous system
2003 • 161 citations
The Influence of Exercise on the Concentrations of Triglyceride and Cholesterol in Human Plasma
1984 • 161 citations
Prevalence of the metabolic syndrome among 40,698 Korean metropolitan subjects
2004 • 159 citations
WHO and ATPIII proposals for the definition of the metabolic syndrome in patients with Type 2 diabetes
2004 • 158 citations
Dense low density lipoproteins and coronary artery disease
1995 • 158 citations
Adverse endothelial function and the insulin resistance syndrome
2000 • 155 citations
Genotype-phenotype correlation in inherited severe insulin resistance
2002 • 155 citations
Insulin Resistance Syndrome in Women with Prior History of Gestational Diabetes Mellitus
2002 • 154 citations
The Metabolic Syndrome in the West Bank Population
2001 • 152 citations
Diet composition and the metabolic syndrome: what is the optimal fat intake?
2002 • 152 citations
Epizootiologic patterns of diabetes mellitus in cats: 333 cases (1980-1986).
1990 • 151 citations
The association of energy intake bias with psychological scores of women
1999 • 150 citations
Rhabdomyolysis with HMG‐CoA reductase inhibitors and gemfibrozil combination therapy
2004 • 150 citations
Insulin Secretion and Sensitivity in Black Versus White Prepubertal Healthy Children1
1997 • 148 citations
Type 2 Diabetes and Metabolic Syndrome in Filipina-American Women
2002 • 148 citations
Blood Lipid Measurements
1992 • 146 citations
Glucose-fatty acid interactions in health and disease
1998 • 146 citations
Dual Roles of Adiponectin / Acrp30 In Vivo as an Anti-Diabetic and Anti- Atherogenic Adipokine
2003 • 145 citations
Dietary Sodium Intake and Incidence of Congestive Heart Failure in Overweight US Men and Women
2002 • 144 citations
Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia
1980 • 144 citations
Comparison of the Effects on Insulin Sensitivity of High Carbohydrate and High Fat Diets in Normal Subjects*
1991 • 143 citations
The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation
2004 • 141 citations
Comparisons of metabolism of apolipoprotein B in normal subjects, obese patients, and patients with coronary heart disease.
1985 • 140 citations
The Role of TNF-α in Human Adipose Tissue: Prevention of Weight Gain at the Expense of Insulin Resistance?
1999 • 140 citations
Ethnic differences in abdominal visceral fat accumulation between Japanese, African-Americans, and Caucasians: a meta-analysis
2003 • 139 citations
Effects of Exercise and Weight Loss on Cardiac Risk Factors Associated With Syndrome X
2003 • 139 citations
A BREIF ORIGINAL CONTRIBUTION
1995 • 139 citations
Apolipoprotein C-III, a strong discriminant of coronary risk in men and a determinant of the metabolic syndrome in both genders
2003 • 137 citations
Association Between the PPARA L162V Polymorphism and Plasma Lipid Levels
2002 • 137 citations
Long-Term Epidemiologic Prediction of Coronary Disease
1993 • 136 citations
Lipolysis in human adipocytes, effects of cell size, age and of regional differences.
1988 • 135 citations
Lipodystrophies: rare disorders causing metabolic syndrome
2004 • 135 citations
Role of lipids, lipoproteins and vitamins in women with breast cancer
2001 • 135 citations
Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle
2003 • 135 citations
Clinical, haemodynamic, anthropometric, metabolic and insulin profile of men with high‐stage and high‐grade clinical prostate cancer
2004 • 133 citations
Identification of multiple dense LDL subfractions with enhanced susceptibility to in vitro oxidation among hypertriglyceridemic subjects. Normalization after clofibrate treatment.
1993 • 133 citations
Insulin receptor substrate proteins and diabetes
2004 • 132 citations
Genetic Polymorphism PC-1 K121Q and Ethnic Susceptibility to Insulin Resistance
2003 • 132 citations
Blood pressure is linked to salt intake and modulated by the angiotensinogen gene in normotensive and hypertensive elderly subjects
2001 • 131 citations
Biochemical Mechanism of Lipid-induced Impairment of Glucose-stimulated Insulin Secretion and Reversal with a Malate Analogue
2004 • 131 citations
Intercorrelations among plasma high density lipoprotein, obesity and triglycerides in a normal population
1980 • 130 citations
Glucose scavenging of nitric oxide
2001 • 130 citations
Physiological Increase in Plasma Leptin Markedly Inhibits Insulin Secretion In Vivo
2001 • 129 citations
Weight Loss–Associated Induction of Peroxisome Proliferator–Activated Receptor-α and Peroxisome Proliferator–Activated Receptor-γ Correlate With Reduced Atherosclerosis and Improved Cardiovascular Function in Obese Insulin-Resistant Mice
2004 • 128 citations
Identification of Subjects with Insulin Resistance and β-Cell Dysfunction Using Alternative Definitions of the Metabolic Syndrome
2003 • 126 citations
Studies of the Pro12Ala Polymorphism of the PPAR-γ Gene in the Danish MONICA Cohort: Homozygosity of the Ala Allele Confers a Decreased Risk of the Insulin Resistance Syndrome
2002 • 124 citations
A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study
1999 • 124 citations
Obesity and cardiovascular risk intervention through the ad libitum feeding of traditional Hawaiian diet
1991 • 124 citations
Breast-cancer incidence in relation to height, weight and body-fat distribution in the Dutch “DOM” cohort
1998 • 121 citations
Epidemiology and treatment of the metabolic syndrome
2004 • 121 citations
Obesity, Weight Gain, Large Weight Changes, and Adenomatous Polyps of the Left Colon and Rectum
1998 • 119 citations
Overexpressing Human Lipoprotein Lipase in Mouse Skeletal Muscle Is Associated With Insulin Resistance
2001 • 119 citations
Insulin-like growth factor-I and cancer risk
2004 • 117 citations
Improvements in blood pressure, glucose metabolism, and lipoprotein lipids after aerobic exercise plus weight loss in obese, hypertensive middle-aged men
1998 • 117 citations
Dietary habits and incidence of noninsulin-dependent diabetes mellitus in a population study of women in Gothenburg, Sweden
1989 • 116 citations
Effect of pravastatin and omega-3 fatty acids on plasma lipids and lipoproteins in patients with combined hyperlipidemia.
1993 • 116 citations
Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans
2004 • 115 citations
Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase
1997 • 114 citations
Pressor Effects of Portal Venous Oleate Infusion
1995 • 114 citations
Effects of extended-release niacin on lipoprotein subclass distribution
2003 • 112 citations
Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids--a review.
2000 • 108 citations
Heritability of factors of the insulin resistance syndrome in women twins
1997 • 107 citations
Caloric Restriction in Primates
2001 • 107 citations
Recommendations for special populations: diabetes mellitus and the metabolic syndrome
2003 • 105 citations
Effects of a Low Saturated Fat, Low Cholesterol Fish Oil Supplement in Hypertriglyceridemic Patients
1988 • 104 citations
Metabolic abnormalities: triglyceride and low-density lipoprotein
2004 • 103 citations
Polymorphisms in the Fatty Acid-Binding Protein 2 and Apolipoprotein C-III Genes Are Associated with the Metabolic Syndrome and Dyslipidemia in a South Indian Population
2005 • 102 citations
The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense Forces health study.
2006 • 102 citations
Prevalence of insulin resistance syndrome in a selected south Indian population--the Chennai urban population study-7 [CUPS-7].
2002 • 101 citations
Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women
1994 • 100 citations
Nutrient intakes and body weights of persons consuming high and moderate levels of added sugars
1992 • 100 citations
Associations of indices of adiposity with atherogenic lipoprotein subfractions
1998 • 99 citations
Associations between diet and the metabolic syndrome vary with the validity of dietary intake data
2003 • 97 citations
Contribution of Hepatic Lipase, Lipoprotein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women
2002 • 97 citations
Simvastatin Does Not Have a Clinically Significant Pharmacokinetic Interaction With Fenofibrate in Humans
2004 • 97 citations
Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion
1998 • 97 citations
Interindividual variation in abdominal subcutaneous and visceral adipose tissue: influence of measurement site
2004 • 96 citations
Association of Body Mass Index, Body Fat, and Weight Gain With Inflammation Markers Among Rural Residents in Japan.
2003 • 95 citations
Effects of ezetimibe added to on-going statin therapy on the lipid profile of hypercholesterolemic patients with diabetes mellitus or metabolic syndrome
2004 • 94 citations
Alterations in lipoprotein lipase in insulin resistance.
1995 • 94 citations
THE RISE AND FALL OF MENOPAUSAL HORMONE THERAPY
2005 • 93 citations
Immunohistochemical morphometry of pancreatic endocrine cells in diabetic, normoglycaemic glucose-intolerant and normal cats
1986 • 92 citations
Fatty Acid Infusion Selectively Impairs Insulin Action on Akt1 and Protein Kinase C λ/ζ but Not on Glycogen Synthase Kinase-3
2002 • 91 citations
The Prevention of Diabetes Mellitus
1940 • 89 citations
Monogenic forms of insulin resistance: apertures that expose the common metabolic syndrome
2003 • 87 citations
Higher prevalence of type 2 diabetes, metabolic syndrome and cardiovascular diseases in gypsies than in non-gypsies in Slovakia
2003 • 87 citations
1: Epidemiology and prevention of type 2 diabetes and the metabolic syndrome
2003 • 86 citations
Fat distribution and insulin response in prepubertal African American and white children
1998 • 85 citations
The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity
1998 • 84 citations
Association Studies between Microsatellite Markers within the Gene Encoding Human 11β-Hydroxysteroid Dehydrogenase Type 1 and Body Mass Index, Waist to Hip Ratio, and Glucocorticoid Metabolism
2002 • 84 citations
Essential hypertension and insulin resistance in non‐insulin‐dependent diabetes
1989 • 81 citations
The Gly16→Arg16and Gln27→Glu27Polymorphisms of β2-Adrenergic Receptor Are Associated with Metabolic Syndrome in Men
2003 • 79 citations
Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease
2003 • 79 citations
A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse
2000 • 79 citations
Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer
2004 • 76 citations
Type 2 diabetes in South Asians: A pathophysiologic focus on the Asian-Indian epidemic
2004 • 76 citations
Risk of breast cancer in relation to blood lipids: a prospective study of 31,209 Norwegian women
1994 • 75 citations
Using Metabolic Syndrome Traits for Efficient Detection of Impaired Glucose Tolerance
2004 • 74 citations
Triglycerides and Coronary Heart Disease: Implications of Recent Clinical Trials
2000 • 73 citations
Hepatic lipase activity influences high density lipoprotein subclass distribution in normotriglyceridemic men: genetic and pharmacological evidence
1999 • 73 citations
Respiratory Uncoupling Lowers Blood Pressure Through a Leptin-Dependent Mechanism in Genetically Obese Mice
2002 • 72 citations
Age-Related Changes in Metabolic Parameters of Nonhuman Primates
2004 • 71 citations
Associations of low density lipoprotein particle composition with atherogenicity
2004 • 70 citations
Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice
2003 • 70 citations
New insights into the pathogenesis of atherosclerosis as revealed by PDAY
1994 • 70 citations
Niacin treatment of the atherogenic lipid profile and Lp(a) in diabetes
2002 • 69 citations
Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity
1998 • 67 citations
Estimating cardiovascular disease risk and the metabolic syndrome: a Framingham view
2004 • 67 citations
Once‐Daily Niacin Extended Release/Lovastatin Combination Tablet Has More Favorable Effects on Lipoprotein Particle Size and Subclass Distribution Than Atorvastatin and Simvastatin
2003 • 66 citations
Weak and non-independent association between plasma TAFI antigen levels and the insulin resistance syndrome
2003 • 66 citations
Genetic variation inLMNAmodulates plasma leptin and indices of obesity in aboriginal Canadians
2000 • 66 citations
Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil
1996 • 66 citations
Obesity: Mechanisms and Clinical Management
2003 • 66 citations
Prevalence of the metabolic syndrome among the Inuit in Greenland. A comparison between two proposed definitions
2004 • 63 citations
Snowballing obesity: Australians will get run over if they just sit there
2003 • 63 citations
Insensitivity of large rat adipocytes to the antilipolytic effects of insulin
1977 • 61 citations
Role of insulin resistance in the genesis of sodium sensitivity in essential hypertension
1999 • 61 citations
Health Consequences of Fat Distribution
1997 • 60 citations
Contribution of the cholesteryl ester transfer protein gene TaqIB polymorphism to the reduced plasma HDL-cholesterol levels found in abdominal obese men with the features of the insulin resistance syndrome
1999 • 59 citations
A dose‐ranging study of a new, once‐daily, dual‐component drug product containing niacin extended‐release and lovastatin
2003 • 59 citations
Mapping the Genetic Determinants of Hypertension, Metabolic Diseases, and Related Phenotypes in the Lyon Hypertensive Rat
2004 • 58 citations
Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study
2000 • 58 citations
The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903]
2003 • 58 citations
Identification of Quantitative Trait Loci for Glucose Homeostasis
2004 • 57 citations
Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats
2000 • 56 citations
Effectiveness of multidisciplinary lifestyle intervention for hypertension: a randomised controlled trial
2003 • 56 citations
Lack of Proopiomelanocortin Peptides Results in Obesity and Defective Adrenal Function but Normal Melanocyte Pigmentation in the Murine C57BL/6 Genetic Background
2003 • 55 citations
Extended-release niacin treatment of the atherogenic lipid profile and lipoprotein(a) in diabetes
2002 • 55 citations
Does Gastric Restriction Surgery Reduce the Risks of Metabolic Diseases?
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Mechanisms of Disease: ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors
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Nonhuman Primates as Models for the Study of Human Diabetes Mellitus
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Metabolic syndrome and renal sodium handling in three ethnic groups living in England
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Variation in the Lamin A/C Gene
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The effects of monounsaturated-fat enriched diet and polyunsaturated-fat enriched diet on lipid and glucose metabolism in subjects with impaired glucose tolerance.
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Aromatase regulation and breast cancer
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The Q121 PC-1 Variant and Obesity Have Additive and Independent Effects in Causing Insulin Resistance
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Metabolic syndrome: soybean foods and serum lipids.
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Role of IGF-1R in Mediating Breast Cancer Invasion and Metastasis
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The Intestinal Absorption of Biliary and Dietary Cholesterol as a Drug Target for Lowering the Plasma Cholesterol Level
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Addressing the Insulin Resistance Syndrome A Role for the Thiazolidinediones
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Antihypertensive treatment of patients with diabetes and hypertension
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Prevalence and lifestyle determinants of the metabolic syndrome.
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Malonyl CoA, Long Chain Fatty Acyl CoA and Insulin Resistance in Skeletal Muscle
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Genetic Dissection of the Syndrome X in the Rat
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Antiplatelet Agents for the Prevention of Cardiovascular Disease in Diabetes Mellitus
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Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings
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Dietary Fish Oil and Insulin Action in Humans
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How to implement dietary changes to prevent the development of metabolic syndrome
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Insulin Resistance, Body Mass Index, Waist Circumference are Independent Risk Factor for High Blood Pressure
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SMXA-5 Mouse as a Diabetic Model Susceptible to Feeding a High-fat Diet
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Levels and physicochemical properties of lipoprotein subclasses in moderate hypertriglyceridemia
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The Q121 PC-1 Variant and Obesity Have Additive and Independent Effects in Causing Insulin Resistance
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