Obesity and cancer

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

2002 • 15,184 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Prevalence and Trends in Obesity Among US Adults, 1999-2000

2002 • 6,312 citations

Nutritional Epidemiology

1998 • 4,376 citations

Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000

2002 • 4,212 citations

Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults

1999 • 3,707 citations

Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma

1999 • 3,031 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer

1997 • 2,438 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

The Spread of the Obesity Epidemic in the United States, 1991-1998

1999 • 2,316 citations

Body Weight and Mortality among Women

1995 • 2,018 citations

Annual Deaths Attributable to Obesity in the United States

1999 • 1,924 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Do Obese Children Become Obese Adults? A Review of the Literature

1993 • 1,842 citations

Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women: Reanalysis of Nine Prospective Studies

2002 • 1,729 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

S<scp>UCCESSFUL</scp> W<scp>EIGHT</scp> L<scp>OSS</scp> M<scp>AINTENANCE</scp>

2001 • 1,374 citations

An Adoption Study of Human Obesity

1986 • 1,308 citations

The Worldwide Obesity Epidemic

2001 • 1,213 citations

Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. Writing Group for the Women's Health Initiative Investigators. &lt;I&gt;JAMA&lt;/I&gt; 2002; 288(3): 321-333

2002 • 1,204 citations

Variations in mortality by weight among 750,000 men and women

1979 • 1,200 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

Guidelines for Healthy Weight

1999 • 1,158 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1997 • 1,125 citations

Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk

2000 • 1,075 citations

Overweight, Obesity, and Health Risk

2000 • 962 citations

Insulin-Like Growth Factors

1997 • 897 citations

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

2000 • 896 citations

Dual Effects of Weight and Weight Gain on Breast Cancer Risk

1997 • 813 citations

Criteria for definition of overweight in transition: background and recommendations for the United States

2000 • 698 citations

Diabetes Mellitus as a Risk Factor for Pancreatic Cancer

1995 • 694 citations

Obesity, Hypertension, and the Risk of Kidney Cancer in Men

2000 • 661 citations

Physical Activity, Obesity, Height, and the Risk of Pancreatic Cancer

2001 • 653 citations

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

2000 • 653 citations

Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia

1998 • 631 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Does physical activity prevent weight gain – a systematic review

2000 • 607 citations

Obesity

1997 • 575 citations

A prospective study of obesity and cancer risk (Sweden).

2001 • 575 citations

Prevalence of Attempting Weight Loss and Strategies for Controlling Weight

1999 • 539 citations

Obesity

2002 • 532 citations

Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma.

1995 • 529 citations

The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk

1988 • 529 citations

Diet, Body Size, and Breast Cancer

1993 • 497 citations

Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer

1999 • 496 citations

Insulin, Insulin-Like Growth Factor-I (IGF-I), IGF Binding Proteins, Their Biologic Interactions, and Colorectal Cancer

2002 • 490 citations

Age Changes in Body Composition Revealed by Computed Tomography

1983 • 468 citations

Obesity and cancer risk: a danish record-linkage study

1994 • 446 citations

Review: The treatment and prevention of obesity: a systematic review of the literature

1997 • 444 citations

Abnormal Glucose Metabolism and Pancreatic Cancer Mortality

2000 • 412 citations

Body Size and Prostate Cancer: A 20-Year Follow-up Study Among 135006 Swedish Construction Workers

1997 • 405 citations

Insulin resistance and breast‐cancer risk

1992 • 366 citations

The Relation of Gastroesophageal Reflux Disease and Its Treatment to Adenocarcinomas of the Esophagus and Gastric Cardia

1995 • 366 citations

Estrogen Replacement Therapy and Risk of Fatal Colon Cancer in a Prospective Cohort of Postmenopausal Women

1995 • 364 citations

ACCURACY OF CURRENT, 4-YEAR, AND 28-YEAR SELF-REPORTED BODY WEIGHT IN AN ELDERLY POPULATION

1990 • 361 citations

Nutrition, hormones, and breast cancer: Is insulin the missing link?

1996 • 358 citations

Serum insulin-like growth factor-I and breast cancer

2000 • 347 citations

INCREASED INCIDENCE OF CARCINOMA OF THE BREAST ASSOCIATED WITH ABDOMINAL ADIPOSITY IN POSTMENOPAUSAL WOMEN

1990 • 335 citations

Insulin-like Growth Factors and Cancer

1995 • 321 citations

American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity

2002 • 316 citations

Insulin and related factors in premenopausal breast cancer risk

1998 • 309 citations

Screening for Cervical and Breast Cancer: Is Obesity an Unrecognized Barrier to Preventive Care?

2000 • 298 citations

Physical activity, obesity, and risk of colorectal adenoma in women (United States)

1996 • 290 citations

Epidemiologic Aspects of Gallbladder Cancer: A Case-Control Study of the SEARCH Program of the International Agency for Research on Cancer

1997 • 284 citations

Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

1993 • 276 citations

Behavioral Strategies of Individuals Who Have Maintained Long‐Term Weight Losses

1999 • 272 citations

Dietary and Nutritional Factors and Pancreatic Cancer: a Case-Control Study Based on Direct Interviews

1998 • 263 citations

Breast Cancer and Obesity: An Update

2003 • 256 citations

The Human Obesity Gene Map: The 2002 Update

2003 • 242 citations

Risk factors for gallbladder cancer. An international collaborative case–control study

1995 • 235 citations

Progress in obesity research: 7

1996 • 235 citations

Obesity

1997 • 228 citations

The role of diabetes mellitus in the aetiology of renal cell cancer

1999 • 227 citations

Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women.

2002 • 224 citations

Insulin‐like growth‐factor‐binding protein 3 is decreased in early‐stage operable pre‐menopausal breast cancer

1995 • 219 citations

Body Size and Risk of Breast Cancer

1997 • 218 citations

Reversal of Relation Between Body Mass and Endogenous Estrogen Concentrations With Menopausal Status

1996 • 208 citations

IGF-I and IGF-II in relation to colorectal cancer

1999 • 190 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Case-Control Study of Non-Hodgkin's Lymphoma among Women and Heterosexual Men in the San Francisco Bay Area, California

1999 • 185 citations

Growth hormone treatment induces mammary gland hyperplasia in aging primates

1997 • 175 citations

Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis

1995 • 152 citations

Insulin Resistance and Its Contribution to Colon Carcinogenesis

2003 • 151 citations

A twin study of human obesity

1986 • 150 citations

Body weight: estimation of risk for breast and endometrial cancers

1996 • 149 citations

Risk factors for renal‐cell cancer in Shanghai, China

1992 • 146 citations

Serum hormone levels in relation to reproductive and lifestyle factors in postmenopausal women (United States).

1998 • 140 citations

Diabetes mellitus and pancreatic cancer mortality in a prospective cohort of United States adults.

1998 • 140 citations

Body size and survival in premenopausal breast cancer

1985 • 139 citations

Mitotic chromatin regulates phosphorylation of Stathmin/Op18

1997 • 131 citations

Body fat distribution and 5-year risk of death in older women

1993 • 126 citations

Physical Activity, Waist-to-Hip Ratio, and Other Risk Factors for Ovarian Cancer

1996 • 124 citations

Breast-cancer incidence in relation to height, weight and body-fat distribution in the Dutch “DOM” cohort

1998 • 121 citations

Race, Nutritional Status, and Survival From Breast Cancer

1990 • 121 citations

NUTRIENT INTAKE AND OVARIAN CANCER

1989 • 115 citations

The effect of pre-morbid height and weight on the survival of breast cancer patients

1990 • 112 citations

Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer

2000 • 111 citations

Early body size and subsequent weight again as predictors of breast cancer incidence (Iowa, United States)

1995 • 107 citations

Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Qu�bec family study

1999 • 106 citations

Nutrition and renal cell cancer

1996 • 105 citations

The Body Mass Index‐Mortality Relationship in White and African American Women

1998 • 105 citations

Body size and ovarian cancer: case-control study and systematic review (Australia).

2001 • 100 citations

ASSOCIATION OF OBESITY AND OVARIAN CANCER IN A CASE-CONTROL STUDY

1989 • 92 citations

Caloric restriction and experimental carcinogenesis

1999 • 91 citations

Genetic Influences on Adult Weight Gain and Maximum Body Mass Index in Male Twins

1994 • 89 citations

Anthropometric predictors of breast cancer incidence and survival in a multi-ethnic cohort of female residents of Hawaii, United States.

1998 • 84 citations

Genetic Variability of Adult Body Mass Index: A Longitudinal Assessment in Framingham Families

2002 • 84 citations

Risk factors for renal‐cell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors

1994 • 82 citations

Obesity and risk of renal cell cancer.

1996 • 82 citations

Pre-morbid body-mass-index in breast cancer: Reversed effect on survival in hormone receptor negative patients

1996 • 80 citations

Nutrition and endometrial cancer

1996 • 80 citations

Genetics of Obesity

2002 • 75 citations

Leanness and Lung Cancer Risk: Fact or Artifact?

2002 • 74 citations

Body mass and breast cancer: Relationship between method of detection and stage of disease

1996 • 74 citations

Genetic Influences on Changes in Body Mass Index: A Longitudinal Analysis of Women Twins

1997 • 55 citations

Genetics of human obesity

2001 • 53 citations

Height, weight and cancer of the oesophagus and stomach

1999 • 44 citations

Body mass and 26 y risk of mortality among men who never smoked: a re-analysis among men from the Adventist Mortality Study

1998 • 34 citations

Endocrinology of breast cancer

1987 • 32 citations

Can dietary intervention produce long-term reductionin insulin resistance?

2000 • 25 citations

Role of the IGF System in Breast Cancer Proliferation and Progression

1999 • 9 citations