Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions

1999 • 3,605 citations

Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity☆, ☆☆

1999 • 3,339 citations

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

2003 • 2,629 citations

Nonalcoholic Fatty Liver Disease

2001 • 2,567 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference

2003 • 2,157 citations

Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities

2001 • 2,021 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis

1999 • 1,610 citations

Superoxide activates mitochondrial uncoupling proteins

2002 • 1,364 citations

Nonalcoholic Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Liver Fibrosis in the Severely Obese

2001 • 1,341 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

The Prevalence and Etiology of Elevated Aminotransferase Levels in The United States

2003 • 1,274 citations

Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus

1999 • 1,270 citations

Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors

1990 • 1,210 citations

Leptin regulates proinflammatory immune responses

1998 • 1,161 citations

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

2002 • 1,131 citations

Metformin: An Update

2002 • 1,048 citations

Liver fibrosis in overweight patients

2000 • 966 citations

Cytokines in Alcoholic and Nonalcoholic Steatohepatitis

2000 • 936 citations

Nonalcoholic fatty liver disease

2002 • 894 citations

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

2003 • 893 citations

The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis

2001 • 820 citations

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

1997 • 815 citations

Genetics of body-weight regulation

2000 • 797 citations

Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association

2002 • 760 citations

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

2000 • 746 citations

Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis

2003 • 740 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis

2004 • 729 citations

Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial

2004 • 723 citations

Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone

2003 • 716 citations

Milk Thistle ( Silybum marianum ) for the Therapy of Liver Disease

1998 • 708 citations

Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

1999 • 704 citations

Antibiotics prevent liver injury in rats following long-term exposure to ethanol

1995 • 698 citations

Clinical Features and Natural History of Nonalcoholic Steatosis Syndromes

2001 • 691 citations

Metformin reverses fatty liver disease in obese, leptin-deficient mice

2000 • 680 citations

Etiopathogenesis of Nonalcoholic Steatohepatitis

2001 • 678 citations

Gene expression of tumor necrosis factor [alpha ] and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients

2001 • 677 citations

Influence of body fat distribution on free fatty acid metabolism in obesity.

1989 • 676 citations

Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis

1998 • 668 citations

Therapeutic effects of restricted diet and exercise in obese patients with fatty liver

1997 • 624 citations

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

1998 • 611 citations

Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study

1996 • 564 citations

Mitochondrial disorders

2003 • 543 citations

High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis

2001 • 537 citations

Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin E

2003 • 523 citations

Insulin resistance–associated hepatic iron overload

1999 • 502 citations

Nonalcoholic Steatohepatitis

1997 • 488 citations

Leptin regulates proinflammatory immune responses

1998 • 487 citations

Alterations in Liver ATP Homeostasis in Human Nonalcoholic Steatohepatitis

1999 • 481 citations

Animal Models of Steatosis

2001 • 446 citations

Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion

1999 • 442 citations

Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study

2001 • 428 citations

Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

2003 • 424 citations

Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

2004 • 423 citations

Plasma transforming growth factor‐β1 level and efficacy of α‐tocopherol in patients with non‐alcoholic steatohepatitis: a pilot study

2001 • 415 citations

Metformin in the treatment of patients with non‐alcoholic steatohepatitis

2004 • 409 citations

Mitochondria in Steatohepatitis

2001 • 404 citations

Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease

2001 • 400 citations

Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes

1998 • 394 citations

A Pilot Study of A Thiazolidinedione, Troglitazone, in Nonalcoholic Steatohepatitis

2001 • 392 citations

Effect of weight reduction on hepatic abnormalities in overweight patients

1990 • 381 citations

Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates ofob/obmice

2002 • 372 citations

Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis

1999 • 369 citations

Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?

2002 • 368 citations

Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone

2003 • 359 citations

Lipoapoptosis: its mechanism and its diseases

2002 • 358 citations

II. CytochromeP-450 enzymes and oxidative stress

2001 • 353 citations

A new syndrome of liver iron overload with normal transferrin saturation

1997 • 343 citations

Increased gastrointestinal ethanol production in obese mice: Implications for fatty liver disease pathogenesis

2000 • 341 citations

Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis

2003 • 336 citations

Apolipoprotein synthesis in nonalcoholic steatohepatitis

2002 • 327 citations

Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

1995 • 312 citations

Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans

1993 • 301 citations

Effect on Hepatic Morphology of Treatment of Obesity by Fasting, Reducing Diets and Small-Bowel Bypass

1970 • 297 citations

Tumor necrosis factor α promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease

2002 • 293 citations

Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis

1997 • 284 citations

V. Mitochondrial dysfunction in steatohepatitis

2002 • 282 citations

Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity

2000 • 276 citations

Hemosiderosis in cirrhosis: A study of 447 native livers

1997 • 267 citations

Liporegulation in Diet-induced Obesity

2001 • 265 citations

REVIEW: Nonalcoholic steatohepatitis

1997 • 254 citations

HFE mutations, hepatic iron, and fibrosis: Ethnic-specific association of NASH with C282Y but not with fibrotic severity

2002 • 250 citations

Serum Leptin Levels in Patients With Nonalcoholic Steatohepatitis

2000 • 249 citations

Hepatic iron and nonalcoholic fatty liver disease

1999 • 240 citations

Hepatic Steatosis After Intestinal Bypass—Prevention and Reversal by Metronidazole, Irrespective of Protein-Calorie Malnutrition

1982 • 233 citations

III. Peroxisomal β-oxidation, PPARα, and steatohepatitis

2001 • 230 citations

Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver

2002 • 226 citations

Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis

2001 • 224 citations

The Transcriptional and DNA Binding Activity of Peroxisome Proliferator-activated Receptor α Is Inhibited by Ethanol Metabolism

2001 • 214 citations

Non-alcoholic fatty liver disease: lumen–liver interactions and possible role for probiotics

2003 • 211 citations

Obesity and Female Gender Increase Breath Ethanol Concentration: Potential Implications for The Pathogenesis of Nonalcoholic Steatohepatitis

2001 • 205 citations

Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver

1999 • 198 citations

Non-alcoholic steatohepatitis (NASH): where are we now and where are we going?

2002 • 183 citations

Not all fat is alike

1998 • 176 citations

Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease

2000 • 168 citations

Evidence for mitochondrial DNA damage by lipid peroxidation

1988 • 160 citations

Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with Type II diabetes

2000 • 159 citations

I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription

2001 • 152 citations

Does Leptin Play A Role in The Pathogenesis of Human Nonalcoholic Steatohepatitis?

2003 • 145 citations

Interim results of a pilot study demonstrating the early effects of the PPAR-γ ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis

2003 • 128 citations

Leptin, obesity, and liver disease

1998 • 127 citations

Non‐alcoholic fatty liver disease

2003 • 111 citations

Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system

2002 • 105 citations

Orlistat in the treatment of NASH: a case series

2003 • 94 citations

Postprandial triglyceride‐rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients

2001 • 92 citations

Dietary fat and alcoholic liver disease

1998 • 88 citations

Interaction of iron, insulin resistance, and nonalcoholic steatohepatitis

2003 • 88 citations

Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2

2002 • 87 citations

Mitochondrial Disorders

1998 • 85 citations

NONALCOHOLIC STEATOHEPATITIS

1996 • 76 citations

Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial

1998 • 75 citations

Steatohepatitis associated with limb lipodystrophy

1989 • 75 citations

Review article: S‐Adenosyl‐L‐Methionine–a new therapeutic agent in liver disease?

1993 • 41 citations

Liver transplantation for jejunoileal bypass-associated cirrhosis: Allograft histology in the setting of an intact bypassed limb

1997 • 24 citations

Pentoxyphylline as a novel therapy for non alcoholic steatohepatitis: A pilot study

2003 • 4 citations

Ghrelin in non-alcoholic fatty liver disease

2003 • 2 citations