A transgenic mouse model for monitoring endoplasmic reticulum stress

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

2002 • 2,692 citations

Homocysteine and Cardiovascular Disease

1998 • 2,177 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

Coupling endoplasmic reticulum stress to the cell death program

2004 • 1,172 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum

2000 • 917 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

2003 • 597 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1999 • 521 citations

An essential role in liver development for transcription factor XBP-1

2000 • 503 citations

Homocysteine-Induced Endoplasmic Reticulum Stress and Growth Arrest Leads to Specific Changes in Gene Expression in Human Vascular Endothelial Cells

1999 • 347 citations

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

2001 • 299 citations

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

2000 • 260 citations

Endoplasmic reticulum dysfunction – a common denominator for cell injury in acute and degenerative diseases of the brain?

2001 • 244 citations

Characterization of the stress-inducing effects of homocysteine

1998 • 231 citations

Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease

1997 • 149 citations