Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

Astrocyte–endothelial interactions at the blood–brain barrier

2005 • 4,950 citations

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

2014 • 4,524 citations

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

2012 • 4,121 citations

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

2008 • 2,958 citations

The Blood–Brain Barrier

2015 • 2,593 citations

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

Pericytes regulate the blood–brain barrier

2010 • 2,459 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

2015 • 1,959 citations

Pericytes are required for blood–brain barrier integrity during embryogenesis

2010 • 1,848 citations

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

2012 • 1,593 citations

Blood-Brain Barrier: From Physiology to Disease and Back

2018 • 1,543 citations

The Role of Apolipoprotein E in Alzheimer's Disease

2009 • 1,475 citations

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

1994 • 1,396 citations

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

2019 • 1,222 citations

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

2012 • 1,128 citations

Normal aging induces A1-like astrocyte reactivity

2018 • 1,032 citations

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

2016 • 929 citations

Neurovascular mechanisms of Alzheimer's neurodegeneration

2005 • 903 citations

Pericytes of the neurovascular unit: key functions and signaling pathways

2016 • 899 citations

The blood-brain barrier in systemic inflammation

2016 • 866 citations

Intranasal insulin improves cognition and modulates β-amyloid in early AD

2007 • 794 citations

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

1998 • 783 citations

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

2011 • 732 citations

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

1998 • 728 citations

Intranasal insulin improves memory in humans

2004 • 665 citations

Do astrocytes really exocytose neurotransmitters?

2010 • 641 citations

Delivery of therapeutic agents to the central nervous system: the problems and the possibilities

2004 • 641 citations

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

2009 • 617 citations

Role for neuronal insulin resistance in neurodegenerative diseases

2004 • 601 citations

Pericyte physiology

1993 • 582 citations

Garbage Truck of the Brain

2013 • 571 citations

Amyloid beta oligomers induce impairment of neuronal insulin receptors

2007 • 559 citations

RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice

2013 • 558 citations

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

2015 • 555 citations

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease

1998 • 550 citations

Insulin in the brain: There and back again

2012 • 516 citations

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor.

2002 • 497 citations

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

2008 • 495 citations

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

2018 • 486 citations

Insulin receptors and insulin action in the brain: review and clinical implications

2000 • 478 citations

The source of cerebral insulin

2004 • 473 citations

Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in <scp>A</scp>lzheimer's Disease

2012 • 470 citations

Regional Cerebral Metabolic Alterations in Dementia of the Alzheimer Type

1983 • 465 citations

Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier

2003 • 458 citations

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

2015 • 456 citations

Strategies to advance translational research into brain barriers

2008 • 450 citations

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

2016 • 443 citations

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

2008 • 394 citations

The Role of Insulin Resistance in the Pathogenesis of Alzheimer??s Disease

2003 • 390 citations

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

2015 • 377 citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

2003 • 329 citations

The Insulin Receptor Tyrosine Kinase Substrate p58/53 and the Insulin Receptor Are Components of CNS Synapses

1999 • 326 citations

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

2017 • 314 citations

Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.

2000 • 314 citations

Differential Permeability of the Blood–Brain Barrier to Two Pancreatic Peptides: Insulin and Amylin

1998 • 313 citations

Transport of Insulin Across the Blood-Brain Barrier: Saturability at Euglycemic Doses of Insulin

1997 • 312 citations

Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention

2004 • 312 citations

Blood—Brain Barrier Glucose Transporter

1999 • 298 citations

Distribution of insulin receptor-like immunoreactivity in the rat forebrain

1989 • 297 citations

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

2018 • 294 citations

Insulin in the Cerebrospinal Fluid

1967 • 283 citations

Microvessel Organization and Structure in Experimental Brain Tumors: Microvessel Populations with Distinctive Structural and Functional Properties

1999 • 278 citations

Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier

2018 • 269 citations

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

2002 • 264 citations

Insulin in the Brain: Sources, Localization and Functions

2012 • 261 citations

Induction of Astrocyte Differentiation by Endothelial Cells

2001 • 259 citations

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

2015 • 254 citations

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

2009 • 242 citations

Inflammatory Cell Migration into the Central Nervous System: A Few New Twists on an Old Tale

2007 • 238 citations

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model

2011 • 234 citations

Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels.

1983 • 234 citations

Insulin Transiently Increases Tau Phosphorylation

1999 • 233 citations

Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis

2007 • 232 citations

Effect of LPS on the permeability of the blood–brain barrier to insulin

2001 • 221 citations

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

2018 • 217 citations

Selective, Physiological Transport of Insulin Across the Blood-Brain Barrier: Novel Demonstration by Species-Specific Radioimmunoassays

1997 • 213 citations

Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease

2014 • 208 citations

The cellular and physiological actions of insulin in the central nervous system

1993 • 206 citations

Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis

2016 • 206 citations

Neuroinflammation: Ways in Which the Immune System Affects the Brain

2015 • 203 citations

Insulin receptor signaling in the development of neuronal structure and function

2010 • 194 citations

The CNS microvascular pericyte: pericyte-astrocyte crosstalk in the regulation of tissue survival

2011 • 187 citations

Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport.

1991 • 183 citations

Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal

1989 • 173 citations

Insulin regulates astrocyte gliotransmission and modulates behavior

2018 • 170 citations

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

2017 • 158 citations

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes

2011 • 143 citations

Effect of Diabetes Mellitus on the Permeability of the Blood–Brain Barrier to Insulin

1997 • 142 citations

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

2009 • 142 citations

A novel high-affinity peptide antagonist to the insulin receptor

2008 • 141 citations

Genetically obese zucker rats have abnormally low brain insulin content

1985 • 140 citations

Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo

2005 • 139 citations

The Role of IGF-1 Receptor and Insulin Receptor Signaling for the Pathogenesis of Alzheimers Disease: From Model Organisms to Human Disease

2009 • 138 citations

Sequential Changes of Tau-Site-Specific Phosphorylation during Development of Paired Helical Filaments

1996 • 131 citations

Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time

2017 • 122 citations

Neurons and ECM regulate occludin localization in brain endothelial cells

2000 • 122 citations

Enhanced leptin transport across the blood–brain barrier by α1-adrenergic agents

2001 • 122 citations

Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons

2000 • 119 citations

Insulin transport across the blood–brain barrier can occur independently of the insulin receptor

2018 • 113 citations

Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition

2015 • 111 citations

Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier

2008 • 111 citations

Permeability of Proteins at the Blood–Brain Barrier in the Normal Adult Mouse and Double Transgenic Mouse Model of Alzheimer's Disease

2001 • 110 citations

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

2014 • 109 citations

Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice

2011 • 109 citations

Lipids and Cognition

2010 • 105 citations

Insulin resistance in Alzheimer's disease

2016 • 104 citations

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

2017 • 104 citations

Examination of Blood — Brain Barrier Permeability in Dementia of the Alzheimer Type with [⁶⁸Ga]EDTA and Positron Emission Tomography

1987 • 104 citations

Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult <scp>APP</scp> swe/ <scp>PS</scp> 1dE9 mice

2016 • 96 citations

Brain Insulin Impairs Amyloid-β(1-40) Clearance from the Brain

2004 • 94 citations

Unravelling the regulation of insulin transport across the brain endothelial cell

2017 • 92 citations

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine

2012 • 89 citations

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

2015 • 84 citations

High glucose downregulates glucose transport activity in retinal capillary pericytes but not endothelial cells.

1994 • 83 citations

Differential modulation of plasma β-amyloid by insulin in patients with Alzheimer disease

2006 • 83 citations

Enhanced Insulin Binding to Blood-Brain Barrier In Vivo and to Brain Microvessels In Vitro in Newborn Rabbits

1985 • 83 citations

Permeability of the Blood-Brain Barrier to Albumin and Insulin in the Young and Aged SAMP8 Mouse

2000 • 83 citations

Blood–Brain Barrier Disruption and Neurovascular Unit Dysfunction in Diabetic Mice: Protection with the Mitochondrial Carbonic Anhydrase Inhibitor Topiramate

2016 • 83 citations

Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons

2017 • 79 citations

Toxic effect of a β-amyloid peptide (β22–35) on the hippocampal neuron and its prevention

1993 • 77 citations

Contractile elements in the regulation of macromolecular permeability.

1986 • 76 citations

Astrocytes and Ependymal Glia

2004 • 73 citations

STUDIES OF RADIOACTIVE INJECTED LABELED INSULIN

1954 • 73 citations

Insulin inhibits amyloid β-induced cell death in cultured human brain pericytes

2003 • 72 citations

Uptake and degradation of blood-borne insulin by the olfactory bulb

1999 • 69 citations

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

2011 • 69 citations

Lentivirus-mediated downregulation of hypothalamic insulin receptor expression

2007 • 68 citations

Pericytes in diabetes-associated vascular disease

2016 • 67 citations

Blood–Brain Barrier Integrity in Alzheimer's Disease Patients and Elderly Control Subjects

1998 • 65 citations

Hyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation

2018 • 62 citations

Reciprocal Interactions of Insulin and Insulin-Like Growth Factor I in Receptor-Mediated Transport across the Blood-Brain Barrier

2006 • 59 citations

Pro-angiogenic Role of Insulin: From Physiology to Pathology

2017 • 56 citations

Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain

2017 • 55 citations

Nitric Oxide Isoenzymes Regulate Lipopolysaccharide-Enhanced Insulin Transport across the Blood-Brain Barrier

2008 • 55 citations

Cerebrospinal fluid levels of Alzheimer’s disease biomarkers in middle-aged patients with type 1 diabetes

2014 • 50 citations

Reversal of Diet-Induced Obesity Increases Insulin Transport into Cerebrospinal Fluid and Restores Sensitivity to the Anorexic Action of Central Insulin in Male Rats

2013 • 49 citations

Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice

2009 • 48 citations

Pathways for insulin access to the brain: the role of the microvascular endothelial cell

2016 • 43 citations

Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood–brain barrier

2004 • 41 citations

The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain

2018 • 38 citations

Routes for the delivery of insulin to the central nervous system: A comparative review

2018 • 35 citations

Fate of insulin in the retina: an autoradiographic study.

1983 • 33 citations

Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats

2014 • 33 citations

Cerebrovascular Responses to Insulin in Rats

2009 • 32 citations

Can insulin signaling pathways be targeted to transport Aβ out of the brain?

2015 • 30 citations

CCK increases the transport of insulin into the brain

2016 • 29 citations

Cardiorenal Metabolic Syndrome and Diabetic Cognopathy

2013 • 26 citations

Intranasal Insulin Transport is Preserved in Aged SAMP8 Mice and is Altered by Albumin and Insulin Receptor Inhibition

2017 • 22 citations

Loss of Insulin-Mediated Vasoprotection: Early Effect of Diabetes on Pericyte-Containing Microvessels of the Retina

2007 • 20 citations

The influence of insulin infusion on the metabolism of amyloid β peptides in plasma

2012 • 18 citations

Insulin-induced hyperpolarization in retinal capillary pericytes.

1993 • 18 citations

Estrogen and insulin transport through the blood-brain barrier

2016 • 16 citations

Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples

2018 • 15 citations

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons

2015 • 13 citations

186 Reduced pericyte insulin signalling causes abnormal developmental angiogenesis

2017 • 2 citations