The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

Astrocyte–endothelial interactions at the blood–brain barrier

2005 • 4,950 citations

A global double‐fluorescent Cre reporter mouse

2007 • 3,293 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

2007 • 1,595 citations

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

2001 • 1,202 citations

Astrocyte–endothelial interactions and blood–brain barrier permeability*

2002 • 1,098 citations

Three or more routes for leukocyte migration into the central nervous system

2003 • 1,005 citations

Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis

2009 • 655 citations

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

2001 • 642 citations

Specification of neuronal fates in the ventral neural tube

2001 • 530 citations

Preferential recruitment of interferon‐γ–expressing T_H17 cells in multiple sclerosis

2009 • 507 citations

Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development

2006 • 402 citations

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

2007 • 399 citations

Tight junctions of brain endothelium in vitro are enhanced by astroglia

1987 • 389 citations

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model

1987 • 353 citations

Glial cell influence on the human blood‐brain barrier

2001 • 322 citations

Disruption of central nervous system barriers in multiple sclerosis

2010 • 298 citations

Molecular sieving characteristics of the cultured endothelial monolayer

1987 • 254 citations

The specification of neuronal identity by graded sonic hedgehog signalling

1999 • 252 citations

Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis

2007 • 232 citations

Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

2010 • 216 citations

Barriers in the brain: a renaissance?

2008 • 210 citations

Sonic Hedgehog Pathway Activation Is Induced by Acute Brain Injury and Regulated by Injury-Related Inflammation

2009 • 198 citations

Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?

2010 • 187 citations

Sonic Hedgehog Induces Capillary Morphogenesis by Endothelial Cells through Phosphoinositide 3-Kinase

2003 • 167 citations

Statins reduce human blood–brain barrier permeability and restrict leukocyte migration: Relevance to multiple sclerosis

2006 • 155 citations

Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)

2006 • 149 citations

Differentiation of the brain vasculature: the answer came blowing by the Wnt

2010 • 134 citations

Neovascularization and the appearance of morphological characteristics of the blood-brain barrier in the embryonic mouse central nervous system

1993 • 132 citations

Hedgehog signalling: how to get from Smo to Ci and Gli

2006 • 118 citations

Migration of Multiple Sclerosis Lymphocytes Through Brain Endothelium

2002 • 118 citations

Hedgehog Signaling in Murine Vasculogenesis and Angiogenesis

2004 • 110 citations

Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog‐gli1 in autoimmune encephalomyelitis and multiple sclerosis

2008 • 99 citations

SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

2007 • 83 citations

Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling

2006 • 69 citations

Hedgehog signalling in vascular development

2008 • 67 citations

Differentiation of Brain Endothelial Cells in Cell Culture

1991 • 67 citations

Functions of lipid raft membrane microdomains at the blood–brain barrier

2009 • 62 citations

Th1 and Th2 lymphocyte migration across the human BBB is specifically regulated by interferon β and copolymer-1

2005 • 53 citations

Facilitated sprouting in a peripheral nerve injury

2008 • 47 citations

Differential Expression of Sonic Hedgehog Immunoreactivity During Lesion Evolution in Autoimmune Encephalomyelitis

2005 • 46 citations

Caspase 8 expression and signaling in Fas injury-resistant human fetal astrocytes

2001 • 39 citations

Hedgehog peptide promotes cell polarization and lumen formation in developing mouse submandibular gland

2005 • 33 citations