Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Quantitative estimation of insulin sensitivity.

1979 • 1,822 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Assessment of Insulin Sensitivityin Vivo*

1985 • 1,076 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

1993 • 479 citations

Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats

1986 • 465 citations

Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

Blood-brain barrier transcytosis of insulin in developing rabbits

1987 • 348 citations

Receptor-Mediated Peptide Transport through the Blood-Brain Barrier*

1986 • 309 citations

High-fat meals reduce 24-h circulating leptin concentrations in women.

1999 • 272 citations

The Insulin Sensitivity Index in Nondiabetic Man: Correlation Between Clamp-derived and IVGTT-derived Values

1986 • 243 citations

Dietary fat and body fat: a multivariate study of 205 adult females

1992 • 218 citations

Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.

1990 • 188 citations

A Direct In Vitro Demonstration of Insulin Binding to Isolated Brain Microvessels

1981 • 161 citations

Techniques for the measurement of body composition: a practical guide.

1993 • 157 citations

Insulin Resistance andβ-Cell Dysfunction in Aging: The Importance of Dietary Carbohydrate*

1988 • 155 citations

Initiation and perpetuation of obesity and obesity resistance in rats

1989 • 148 citations

Dietary fat, sugar, and fiber predict body fat content

1994 • 135 citations

Roles of insulin resistance and obesity in regulation of plasma insulin concentrations

2000 • 115 citations

Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats

1990 • 113 citations

Insulin Transport From Plasma Into the Central Nervous System Is Inhibited by Dexamethasone in Dogs

1996 • 112 citations

Obesity-induced hypertension in the dog.

1987 • 93 citations

Reduced Effect of Experimental Peripheral Hyperinsulinemia to Elevate Cerebrospinal Fluid Insulin Concentrations of Obese Zucker Rats*

1987 • 85 citations

Reduced β-cell function contributes to impaired glucose tolerance in dogs made obese by high-fat feeding

1999 • 72 citations

Glucose-induced norepinephrine levels and obesity resistance

1987 • 56 citations

Effect of diet-induced obesity and experimental hyperinsulinemia on insulin uptake into CSF of the rat

1993 • 52 citations

Different Central and Peripheral Responses to Leptin in Rhesus Monkeys: Brain Transport May Be Limited¹

1998 • 38 citations

Ad libitum intake of a high-carbohydrate or high-fat diet in young men: effects on nutrient balances

1997 • 26 citations

Baroreflex sensitivity in the canine model of obesity-induced hypertension

1990 • 3 citations