The cellular and physiological actions of insulin in the central nervous system

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Identification of insulin in rat brain.

1978 • 599 citations

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

1990 • 581 citations

Localization of insulin receptor mRNA in rat brain by in situ hybridization

1990 • 442 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

Blood-brain barrier transcytosis of insulin in developing rabbits

1987 • 348 citations

Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels

1979 • 324 citations

Insulin-Binding Sites in the Rat Brain: In Vivo Localization to the Circumventricular Organs by Quantitative Radioautography*

1979 • 319 citations

Localization and Characterization of Insulin Receptors in Rat Brain and Pituitary Gland Usingin VitroAutoradiography and Computerized Densitometry*

1987 • 319 citations

Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.

1980 • 312 citations

Receptor-Mediated Peptide Transport through the Blood-Brain Barrier*

1986 • 309 citations

Frontiers in Neuroendocrinology, 1973.

1973 • 302 citations

Distribution of insulin receptor-like immunoreactivity in the rat forebrain

1989 • 297 citations

Structural differences between insulin receptors in the brain and peripheral target tissues.

1983 • 265 citations

Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain.

1984 • 255 citations

Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin- insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation

1987 • 249 citations

Cerebrospinal Fluid Insulin Levels Increase During Intravenous Insulin Infusions in Man*

1987 • 247 citations

CENTRAL INSULIN ADMINISTRATION REDUCES NEUROPEPTIDE Y mRNA EXPRESSION IN THE ARCUATE NUCLEUS OF FOOD-DEPRIVED LEAN (Fa/Fa) BUT NOT OBESE (fa/fa) ZUCKER RATS

1991 • 244 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats

1986 • 230 citations

Regional Concentrations of Insulin in the Rat Brain*

1983 • 216 citations

Relationship between plasma and cerebrospinal fluid insulin levels of dogs.

1977 • 216 citations

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

1985 • 195 citations

Purification and properties of insulin receptors from rat liver membranes

1977 • 188 citations

Insulin Binding Sites Localized to Nerve Terminals in Rat Median Eminence and Arcuate Nucleus

1980 • 187 citations

Insulin: its relationship to the central nervous system and to the control of food intake and body weight

1985 • 182 citations

Insulin Is Released from Rat Brain Neuronal Cells in Culture

1986 • 175 citations

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

1986 • 165 citations

Periventricular hypothalamic cells in the rat brain contain insulin mRNA

1986 • 143 citations

Genetically obese zucker rats have abnormally low brain insulin content

1985 • 140 citations

Insulin is ubiquitous in extrapancreatic tissues of rats and humans.

1980 • 140 citations

Glucose-dependent regulation of glucose transport activity, protein, and mRNA in primary cultures of rat brain glial cells.

1988 • 136 citations

Regulation of Rat Brain/HepG2 Glucose Transporter Gene Expression by Insulin and Insulin-Like Growth Factor-I in Primary Cultures of Neuronal and Glial Cells*

1989 • 122 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

Development of Brain Insulin Receptors: Structural and Functional Studies of Insulin Receptors from Whole Brain and Primary Cell Cultures*

1986 • 116 citations

Localization of insulin-like immunoreactivity in the neurons from primary cultures of rat brain

1983 • 115 citations

Binding of [125]insulin to specific receptors and stimulation of nucleotide incorporation in cells cultured from rat brain

1980 • 111 citations

Quantitative Autoradiographic Evidence for Insulin Receptors in the Choroid Plexus of the Rat Brain

1986 • 98 citations

Unique Features of the Insulin Receptor in Rat Brain

1984 • 96 citations

Insulin Binding in Four Regions of the Developing Rat Brain

1984 • 96 citations

Brain and Liver Insulin Binding Is Decreased in Zucker Rats Carrying the ’fa’ Gene*

1985 • 89 citations

Insulin and Insulin-Like Growth Factor I Both Stimulate Metabolism, Growth, and Differentiation in the Postneurula Chick Embryo*

1987 • 85 citations

Radiohistochemical localization of insulin receptors in the adult and developing rat brain

1980 • 83 citations

IMMUNOREACTIVE INSULIN LEVELS ARE ELEVATED IN THE CEREBROSPINAL FLUID OF GENETICALLY OBESE ZUCKER RATS

1983 • 75 citations

Insulin and related growth factors: effects on the nervous system and mechanism for neurite growth and regeneration

1988 • 70 citations

Characterization of purified insulin receptor subunits.

1984 • 68 citations

Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues

1985 • 68 citations

Insulin receptors in the brain: Structural and physiological characterization

1988 • 67 citations

Effects of insulin and tunicamycin on neuronal insulin receptors in culture

1983 • 66 citations

Evidence against extrapancreatic insulin synthesis.

1981 • 65 citations

Circumventricular Organs: Receptors and Mediators of Direct Peptide Hormone Action on Brain

1983 • 64 citations

Insulin receptors and insulin action in dissociated brain cells

1987 • 61 citations

Insulin stimulates macromolecular synthesis in cultured glial cells from rat brain

1985 • 55 citations

Insulin and Neuroparsin Promote Neurite Outgrowth in Cultured Locust CNS

1990 • 55 citations

Insulin inhibits specific norepinephrine uptake in neuronal cultures from rat brain

1986 • 55 citations

A Comparison of the Insulin and Insulin-Like Growth Factor I Receptors from Rat Brain and Liver*

1988 • 52 citations

Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels

1986 • 51 citations

Effects of Insulin on Cultured Rat Brain Cells: Stimulation of Ornithine Decarboxylase Activity

1981 • 49 citations

Insulin dependent neurite outgrowth in cultured embryonic mouse brain cells

1983 • 48 citations

Immunoreactive insulin from mouse brain cells in culture and whole rat brain

1984 • 45 citations

Adult-level insulin binding is present in term fetal rat CNS membranes

1982 • 45 citations

Insulin Receptors from Guinea Pig Liver and Brain:Structural and Functional Studies

1986 • 45 citations

Insulin Receptors Mediate Growth Effects in Cultured Fetal Neurons. II. Activation of a Protein Kinase that Phosphorylates Ribosomal Protein S6*

1989 • 43 citations

Development of Receptors for Insulin and Insulin-Like Growth Factor-I in Head and Brain of Chick Embryos: Autoradiographic Localization*

1989 • 41 citations

Insulin immunohistochemistry of rodent CNS: Apparent species differences but good correlation with radioimmunological data

1981 • 40 citations

Insulin in the Central Nervous System

1983 • 38 citations

Effect of Streptozocin-Induced Diabetes on Insulin-Receptor Tyrosine Kinase Activity in Obese Zucker Rats

1990 • 38 citations

Quantitative autoradiographic evidence for insulin receptors in the choroid plexus of the rat brain

1986 • 37 citations

Insulin and C-peptide in human brain neurons (insulin/C-peptide/brain peptides/immunohistochemistry/radioimmunoassay).

1983 • 36 citations

Insulin Binding to Brain Microvessels

1983 • 31 citations

Insulin receptor kinase is hyperresponsive in adipocytes of young obese Zucker rats

1987 • 27 citations

Further Evidence for Non-Pancreatic Insulin Immunoreactivity in Guinea Pig Brain

1983 • 26 citations

Characteristics of the β‐Adrenoreceptor from Neuronal and Glial Cells in Primary Cultures of Rat Brain

1986 • 25 citations

Development of brain insulin receptors

1988 • 23 citations

Ontogenesis of the Insulin Receptor in the Rabbit Brain

1986 • 15 citations

Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats

1990 • 14 citations

Insulin Downregulates Alpha-2 Adrenergic Receptors in Cultured Glial Cells

1987 • 10 citations

Structural and functional studies on insulin receptors from alligator brain and liver

1987 • 8 citations

1202 TRANSCRIPTION OF THE INSULIN GENE IN THE BRAIN AND SUBMANDIBULAR GLAND OF THE RAT

1985 • 6 citations