Type 2 Diabetes and Blood Brain Barrier Improvement

NCT06322212

EARLY_PHASE1INTERVENTIONAL

University of California, Los Angeles

52 participants

Started 2024-08-01 · Completed 2026-04-30

Status: Recruiting (as of 12-23-2025)

Conditions

Type2diabetes

Interventions

DIETARY_SUPPLEMENT: Thiamine OTHER: Placebo

Linked Papers (from SciSciNet-V2)

Total Papers117

Background

117

Result

0

Derived

0

Unknown

0

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.

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Background Papers117

LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS

7,145 citations

Saliency, switching, attention and control: a network model of insula function

4,892 citations

The Neurocircuitry of Fear, Stress, and Anxiety Disorders

1,835 citations

Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence

1,262 citations

The Subgenual Anterior Cingulate Cortex in Mood Disorders

1,020 citations

Distinct Cerebellar Contributions to Intrinsic Connectivity Networks

1,012 citations

Decoding the Role of the Insula in Human Cognition: Functional Parcellation and Large-Scale Reverse Inference

Brain Connectivity Related to Working Memory Performance

Interoception in anxiety and depression

Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity

Cognitive Dysfunction and Diabetes Mellitus

Fractionating the Default Mode Network: Distinct Contributions of the Ventral and Dorsal Posterior Cingulate Cortex to Cognitive Control

Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex

Brain Atrophy in Type 2 Diabetes

Role of the anterior insula in task-level control and focal attention

The role of the hippocampus in flexible cognition and social behavior

Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging

The Roles of the Caudate Nucleus in Human Classification Learning

Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition

Prefrontal cortex and flexible cognitive control: Rules without symbols

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition

A convergent functional architecture of the insula emerges across imaging modalities

Brain Structural Changes in Obstructive Sleep Apnea

A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives

Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors

Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders

Influence of Hyperglycemia on Oxidative Stress and Matrix Metalloproteinase-9 Activation After Focal Cerebral Ischemia/Reperfusion in Rats

Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock

High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease

Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview

A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus

Specificity in the Projections of Prefrontal and Insular Cortex to Ventral Striatopallidum and the Extended Amygdala

Chronic kidney disease in US adults with type 2 diabetes: an updated national estimate of prevalence based on Kidney Disease: Improving Global Outcomes (KDIGO) staging

Microstructural White Matter Abnormalities and Cognitive Functioning in Type 2 Diabetes

Cingulate Activation Increases Dynamically with Response Speed under Stimulus Unpredictability

The Human Hippocampus: Cognitive Maps or Relational Memory?

Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes

Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

Reduced Brain Gray Matter Concentration in Patients With Obstructive Sleep Apnea Syndrome

High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effect.

White Matter Integrity in Obstructive Sleep Apnea before and after Treatment

Cognition–Emotion Integration in the Anterior Insular Cortex

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults

Anxious/Depressed Symptoms are Linked to Right Ventromedial Prefrontal Cortical Thickness Maturation in Healthy Children and Young Adults

Relationship between Obstructive Sleep Apnea Severity and Sleep, Depression and Anxiety Symptoms in Newly-Diagnosed Patients

Type 2 diabetes as a risk factor for cognitive impairment: current insights

Role of Peripheral Inflammatory Markers in Postoperative Cognitive Dysfunction (POCD): A Meta-Analysis

Cognition in the Early Stage of Type 2 Diabetes

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands

Diabetic Retinopathy and Cognitive Decline in Older People With Type 2 Diabetes

Effects of Type 2 Diabetes on 12-Year Cognitive Change

Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

Type 2 Diabetes and Cognitive Decline in Middle-Aged Men and Women

Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea

The impact of cognitive functioning on mortality and the development of functional disability in older adults with diabetes: the second longitudinal study on aging

Mapping water exchange across the blood–brain barrier using 3D diffusion‐prepared arterial spin labeled perfusion MRI

Prevalence and Risk Factors of Chronic Kidney Disease among Type 2 Diabetes Patients: A Cross-Sectional Study in Primary Care Practice

Neural Alterations and Depressive Symptoms in Obstructive Sleep Apnea Patients

Regional brain axial and radial diffusivity changes during development

Vascular Pathology and Blood-Brain Barrier Disruption in Cognitive and Psychiatric Complications of Type 2 Diabetes Mellitus

Abnormal Myelin and Axonal Integrity in Recently Diagnosed Patients with Obstructive Sleep Apnea

The Effect of Maintaining Cognition on Risk of Disability and Death

The influence of cognition on self-management of type 2 diabetes in older people

Emotional and neutral declarative memory impairments and associated white matter microstructural abnormalities in adults with type 2 diabetes

Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction

Early Brain Injury Alters the Blood–Brain Barrier Phenotype in Parallel with β-Amyloid and Cognitive Changes in Adulthood

Sex Differences in White Matter Alterations Accompanying Obstructive Sleep Apnea

A two‐stage approach for measuring vascular water exchange and arterial transit time by diffusion‐weighted perfusion MRI

High-dose Parenteral Thiamine in Treatment of Wernicke’s Encephalopathy: Case Series and Review of the Literature

Neural alterations associated with anxiety symptoms in obstructive sleep apnea syndrome

Type 2 Diabetes and Cognitive Impairment

Use of dynamic contrast-enhanced MRI to measure subtle blood–brain barrier abnormalities

Cognitive Decline and Mortality in a Community‐Based Cohort: The Monongahela Valley Independent Elders Survey

Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus

Association Between Cognitive Function and Social Support with Glycemic Control in Adults with Diabetes Mellitus

Brain axial and radial diffusivity changes with age and gender in healthy adults

Regional Brain Gray Matter Changes in Patients with Type 2 Diabetes Mellitus

Increasing Ang1/Tie2 expression by simvastatin treatment induces vascular stabilization and neuroblast migration after stroke

Water Exchange across the Blood‐Brain Barrier in Obstructive Sleep Apnea: An MRI Diffusion‐Weighted Pseudo‐Continuous Arterial Spin Labeling Study

Heart Rate Responses to Autonomic Challenges in Obstructive Sleep Apnea

Effect of chronic kidney disease on the expression of thiamin and folic acid transporters

Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea

Common medications used by patients with type 2 diabetes mellitus: what are their effects on the lipid profile?

A Diffusion Tensor Imaging Study on White Matter Abnormalities in Patients with Type 2 Diabetes Using Tract-Based Spatial Statistics

Verbal memory impairment after left insular cortex infarction

Validity of the Montreal Cognitive Assessment Screener in Adolescents and Young Adults With and Without Congenital Heart Disease

Blood–Brain Barrier Imaging in Human Neuropathologies

Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients?

Insular Cortex Metabolite Changes in Obstructive Sleep Apnea

Magnetic resonance imaging of blood–brain barrier permeability in ischemic stroke using diffusion-weighted arterial spin labeling in rats

Associations between diabetes self-management and microvascular complications in patients with type 2 diabetes

Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus

Vascular recovery promoted by atorvastatin and simvastatin after experimental intracerebral hemorrhage: magnetic resonance imaging and histological study

Global and regional putamen volume loss in patients with heart failure

Amygdala volume linked to individual differences in mental state inference in early childhood and adulthood

Development of T2-relaxation values in regional brain sites during adolescence

Brain abnormalities in cognition, anxiety, and depression regulatory regions in adolescents with single ventricle heart disease

Prevalence and risk factors of chronic kidney disease among Palestinian type 2 diabetic patients: a cross-sectional study

Associations between brain white matter integrity and disease severity in obstructive sleep apnea

Perceived cognitive deficits are associated with diabetes self-management in a multiethnic sample

Reduced caudate nuclei volumes in patients with congenital central hypoventilation syndrome

Measurement of Blood-Brain Barrier Permeability with T₁-Weighted Dynamic Contrast-Enhanced MRI in Brain Tumors: A Comparative Study with Two Different Algorithms

Thiamine Level in Type I and Type II Diabetes Mellitus Patients: A Comparative Study Focusing on Hematological and Biochemical Evaluations

Global and Regional Brain Non-Gaussian Diffusion Changes in Newly Diagnosed Patients with Obstructive Sleep Apnea

Effects of Type 2 Diabetes on Brain Structure and Cognitive Function: African American–Diabetes Heart Study MIND

Metabolite Differences in the Lenticular Nucleus in Type 2 Diabetes Mellitus Shown by Proton MR Spectroscopy

Characteristics of neuropsychological functions in inpatients with poorly‐controlled type 2 diabetes mellitus

Regional brain gray matter changes in adolescents with single ventricle heart disease

Life expectancy with and without cognitive impairment by diabetes status among older Americans

Wernicke’s Encephalopathy and Korsakoff’s Syndrome Revisited

Non-Gaussian Diffusion Imaging Shows Brain Myelin and Axonal Changes in Obstructive Sleep Apnea

Wernicke’s Encephalopathy, Wet Beriberi, and Polyneuropathy in a Patient with Folate and Thiamine Deficiency Related to Gastric Phytobezoar

Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats

Result Papers0

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Derived Papers0

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Unknown Papers0

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